| Disabled-2 (Dab2) inhibits Wnt/beta-catenin signalling by binding LRP6 and promoting its internalization through clathrin. Jiang Y., He X., Howe P.H.
EMBO J. 31:2336-2349(2012) · UniProtKB (2) · Mapped (11) |
| Myosin II isoform switching mediates invasiveness after TGF-beta-induced epithelial-mesenchymal transition. Beach J.R., Hussey G.S., Miller T.E., Chaudhury A., Patel P., Monslow J., Zheng Q., Keri R.A., Reizes O., Bresnick A.R. et al.
Proc. Natl. Acad. Sci. U.S.A. 108:17991-17996(2011) · Mapped (13) |
| Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2. Penheiter S.G., Singh R.D., Repellin C.E., Wilkes M.C., Edens M., Howe P.H., Pagano R.E., Leof E.B.
Mol. Biol. Cell 21:4009-4019(2010) · UniProtKB (1) · Mapped (20) |
| TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Chaudhury A., Hussey G.S., Ray P.S., Jin G., Fox P.L., Howe P.H.
Nat. Cell Biol. 12:286-293(2010) · UniProtKB (1) · Mapped (8) |
| Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions. Jiang Y., Luo W., Howe P.H.
Oncogene 28:2999-3007(2009) · UniProtKB (3) · Mapped (14) |
| Runx1 is a co-activator with FOXO3 to mediate transforming growth factor beta (TGFbeta)-induced Bim transcription in hepatic cells. Wildey G.M., Howe P.H.
J. Biol. Chem. 284:20227-20239(2009) · Mapped (18) |
| TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2. Ramesh S., Qi X.J., Wildey G.M., Robinson J., Molkentin J., Letterio J., Howe P.H.
EMBO Rep. 9:990-997(2008) · Mapped (8) |
| HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells. Bandyopadhyay S., Ashraf M.Z., Daher P., Howe P.H., DiCorleto P.E.
Mol. Cell. Biol. 27:4207-4216(2007) · Mapped (16) |
| Tumor necrosis factor alpha (TNF-alpha) receptor-II is required for TNF-alpha-induced leukocyte-endothelial interaction in vivo. Chandrasekharan U.M., Siemionow M., Unsal M., Yang L., Poptic E., Bohn J., Ozer K., Zhou Z., Howe P.H., Penn M. et al.
Blood 109:1938-1944(2007) · Mapped (14) |
| Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function. Qi X.J., Wildey G.M., Howe P.H.
J. Biol. Chem. 281:813-823(2006) · Mapped (13) |
| Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway. Hocevar B.A., Prunier C., Howe P.H.
J. Biol. Chem. 280:25920-25927(2005) · UniProtKB (2) · Mapped (19) |
| Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). Prunier C., Howe P.H.
J. Biol. Chem. 280:17540-17548(2005) · UniProtKB (2) · Mapped (12) |
| Regulation of the Wnt signaling pathway by disabled-2 (Dab2). Howe P.H.
EMBO J. 22:3084-3094(2003) · UniProtKB (4) · Mapped (37) |
| Smad3 potentiates transforming growth factor beta (TGFbeta )-induced apoptosis and expression of the BH3-only protein Bim in WEHI 231 B lymphocytes. Wildey G.M., Patil S., Howe P.H.
J. Biol. Chem. 278:18069-18077(2003) · Mapped (8) |
| The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. Hocevar B.A., Smine A., Xu X.X., Howe P.H.
EMBO J. 20:2789-2801(2001) · UniProtKB (3) |
