| Targeting the Bcl-2 family of proteins in Hodgkin lymphoma: in vitro cytotoxicity, target modulation and drug combination studies of the Bcl-2 homology 3 mimetic ABT-737. Jayanthan A., Howard S.C., Trippett T., Horton T., Whitlock J.A., Daisley L., Lewis V., Narendran A.
Leuk. Lymphoma 50:1174-1182(2009) · Mapped (4) |
| Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity. Howard S., Berdini V., Boulstridge J.A., Carr M.G., Cross D.M., Curry J., Devine L.A., Early T.R., Fazal L., Gill A.L. et al.
J. Med. Chem. 52:379-388(2009) · Mapped (1) |
| Wise promotes coalescence of cells of neural crest and placode origins in the trigeminal region during head development. Shigetani Y., Howard S., Guidato S., Furushima K., Abe T., Itasaki N.
Dev. Biol. 319:346-358(2008) · Mapped (20) |
| The solution structure of the periplasmic domain of the TonB system ExbD protein reveals an unexpected structural homology with siderophore-binding proteins. Garcia-Herrero A., Peacock R.S., Howard S.P., Vogel H.J.
Mol. Microbiol. 66:872-889(2007) · Mapped (1) |
| Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis. Pang X., Vu P., Byrd T.F., Ghanny S., Soteropoulos P., Mukamolova G.V., Wu S., Samten B., Howard S.T.
Microbiology 153:1229-1242(2007) · UniProtKB (2) |
| The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081. Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L., Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T. et al.
PLoS Genet. 2:2039-2051(2006) · UniProtKB (4,021) |
| Using substrate-binding variants of the cAMP-dependent protein kinase to identify novel targets and a kinase domain important for substrate interactions in Saccharomyces cerevisiae. Deminoff S.J., Howard S.C., Hester A., Warner S., Herman P.K.
Genetics 173:1909-1917(2006) · Mapped (5) |
| Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. Howard N., Abell C., Blakemore W., Chessari G., Congreve M., Howard S., Jhoti H., Murray C.W., Seavers L.C., van Montfort R.L.
J. Med. Chem. 49:1346-1355(2006) · Mapped (1) |
| OAZ regulates bone morphogenetic protein signaling through Smad6 activation. Ku M., Howard S., Ni W., Lagna G., Hata A.
J. Biol. Chem. 281:5277-5287(2006) · Mapped (11) |
| Increased phosphoglucomutase activity suppresses the galactose growth defect associated with elevated levels of Ras signaling in S. cerevisiae. Howard S.C., Deminoff S.J., Herman P.K.
Curr. Genet. 49:1-6(2006) · Mapped (4) |
| Identification and characterization of putative virulence genes and gene clusters in Aeromonas hydrophila PPD134/91. Yu H.B., Zhang Y.L., Lau Y.L., Yao F., Vilches S., Merino S., Tomas J.M., Howard S.P., Leung K.Y.
Appl. Environ. Microbiol. 71:4469-4477(2005) · UniProtKB (48) |
| Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen. Samten B., Howard S.T., Weis S.E., Wu S., Shams H., Townsend J.C., Safi H., Barnes P.F.
J. Immunol. 174:6357-6363(2005) · Mapped (10) |
| Lunatic fringe null female mice are infertile due to defects in meiotic maturation. Hahn K.L., Johnson J., Beres B.J., Howard S., Wilson-Rawls J.
Development 132:817-828(2005) · Mapped (62) |
| The solution structure of the C-terminal domain of TonB and interaction studies with TonB box peptides. Sean Peacock R., Weljie A.M., Peter Howard S., Price F.D., Vogel H.J.
J. Mol. Biol. 345:1185-1197(2005) · Mapped (1) |
| Crystal structure of a 92-residue C-terminal fragment of TonB from Escherichia coli reveals significant conformational changes compared to structures of smaller TonB fragments. Kodding J., Killig F., Polzer P., Howard S.P., Diederichs K., Welte W.
J. Biol. Chem. 280:3022-3028(2005) · Mapped (1) |
| Pharmacogenetic risk factors for osteonecrosis of the hip among children with leukemia. Relling M.V., Yang W., Das S., Cook E.H., Rosner G.L., Neel M., Howard S., Ribeiro R., Sandlund J.T., Pui C.H. et al.
J. Clin. Oncol. 22:3930-3936(2004) · Mapped (12) |
| The Ras/PKA signaling pathway directly targets the Srb9 protein, a component of the general RNA polymerase II transcription apparatus. Chang Y.-W., Howard S.C., Herman P.K.
Mol. Cell 15:107-116(2004) · UniProtKB (1) · Mapped (4) |
| The Ras/PKA signaling pathway may control RNA polymerase II elongation via the Spt4p/Spt5p complex in Saccharomyces cerevisiae. Howard S.C., Hester A., Herman P.K.
Genetics 165:1059-1070(2003) · UniProtKB (1) · Mapped (1) |
| Neuroprotective effects of bcl-2 overexpression in hippocampal cultures: interactions with pathways of oxidative damage. Howard S., Bottino C., Brooke S., Cheng E., Giffard R.G., Sapolsky R.
J. Neurochem. 83:914-923(2002) · Mapped (1) |
| A polymorphic region in Mycobacterium abscessus contains a novel insertion sequence element. Howard S.T., Byrd T.F., Lyons C.R.
Microbiology (Reading, Engl.) 148:2987-2996(2002) · UniProtKB (22) |
| The C-terminal domain of the largest subunit of RNA polymerase II is required for stationary phase entry and functionally interacts with the Ras/PKA signaling pathway. Howard S.C., Budovskaya Y.V., Chang Y.W., Herman P.K.
J. Biol. Chem. 277:19488-19497(2002) · Mapped (3) |
| The Ras/PKA signaling pathway of Saccharomyces cerevisiae exhibits a functional interaction with the Sin4p complex of the RNA polymerase II holoenzyme. Howard S.C., Chang Y.W., Budovskaya Y.V., Herman P.K.
Genetics 159:77-89(2001) · Mapped (2) |
| The rye mutants identify a role for Ssn/Srb proteins of the RNA polymerase II holoenzyme during stationary phase entry in Saccharomyces cerevisiae. Chang Y.W., Howard S.C., Budovskaya Y.V., Rine J., Herman P.K.
Genetics 157:17-26(2001) · Mapped (4) |
| Identification of the dopamine D3 receptor in oligodendrocyte precursors: potential role in regulating differentiation and myelin formation. Bongarzone E.R., Howard S.G., Schonmann V., Campagnoni A.T.
J. Neurosci. 18:5344-5353(1998) · Mapped (2) |
| Analysis of genetic polymorphism in the phospholipase region of Mycobacterium tuberculosis. Vera-Cabrera L., Howard S.T., Laszlo A., Johnson W.M.
J. Clin. Microbiol. 35:1190-1195(1997) · UniProtKB (1) |
in Literature Citations
