| Depletion of eIF4G from yeast cells narrows the range of translational efficiencies genome-wide. Park E.H., Zhang F., Warringer J., Sunnerhagen P., Hinnebusch A.G.
BMC Genomics 12:68-68(2011) · Mapped (12) |
| Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2. Sattlegger E., Barbosa J.A., Moraes M.C., Martins R.M., Hinnebusch A.G., Castilho B.A.
J. Biol. Chem. 286:10341-10355(2011) · Mapped (3) |
| An upstream ORF with non-AUG start codon is translated in vivo but dispensable for translational control of GCN4 mRNA. Zhang F., Hinnebusch A.G.
Nucleic Acids Res. 39:3128-3140(2011) · Mapped (2) |
| Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery. Takacs J.E., Neary T.B., Ingolia N.T., Saini A.K., Martin-Marcos P., Pelletier J., Hinnebusch A.G., Lorsch J.R.
RNA 17:439-452(2011) · Mapped (1) |
| Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1•PABP mRNPs in vivo. Park E.H., Walker S.E., Lee J.M., Rothenburg S., Lorsch J.R., Hinnebusch A.G.
EMBO J. 30:302-316(2011) · Mapped (3) |
| Guanine nucleotide pool imbalance impairs multiple steps of protein synthesis and disrupts GCN4 translational control in Saccharomyces cerevisiae. Iglesias-Gato D., Martin-Marcos P., Santos M.A., Hinnebusch A.G., Tamame M.
Genetics 187:105-122(2011) · Mapped (10) |
| The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway. Mitchell S.F., Walker S.E., Algire M.A., Park E.H., Hinnebusch A.G., Lorsch J.R.
Mol. Cell 39:950-962(2010) · Mapped (14) |
| The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo. Dev K., Qiu H., Dong J., Zhang F., Barthlme D., Hinnebusch A.G.
Mol. Cell. Biol. 30:5218-5233(2010) · Mapped (5) |
| Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes. Govind C.K., Qiu H., Ginsburg D.S., Ruan C., Hofmeyer K., Hu C., Swaminathan V., Workman J.L., Li B., Hinnebusch A.G.
Mol. Cell 39:234-246(2010) · Mapped (16) |
| The C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons. Chiu W.L., Wagner S., Herrmannova A., Burela L., Zhang F., Saini A.K., Valasek L., Hinnebusch A.G.
Mol. Cell. Biol. 30:4415-4434(2010) · Mapped (5) |
| Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4. Cherkasova V., Qiu H., Hinnebusch A.G.
Mol. Cell. Biol. 30:2862-2873(2010) · Mapped (7) |
| Yeast arginine methyltransferase Hmt1p regulates transcription elongation and termination by methylating Npl3p. Wong C.M., Tang H.M., Kong K.Y., Wong G.W., Qiu H., Jin D.Y., Hinnebusch A.G.
Nucleic Acids Res. 38:2217-2228(2010) · Mapped (6) |
| Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome. Saini A.K., Nanda J.S., Lorsch J.R., Hinnebusch A.G.
Genes Dev. 24:97-110(2010) · Mapped (4) |
| Activator Gcn4 employs multiple segments of Med15/Gal11, including the KIX domain, to recruit mediator to target genes in vivo. Jedidi I., Zhang F., Qiu H., Stahl S.J., Palmer I., Kaufman J.D., Nadaud P.S., Mukherjee S., Wingfield P.T., Jaroniec C.P. et al.
J. Biol. Chem. 285:2438-2455(2010) · Mapped (2) |
| NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5. Ginsburg D.S., Govind C.K., Hinnebusch A.G.
Mol. Cell. Biol. 29:6473-6487(2009) · Mapped (23) |
| eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation. Nanda J.S., Cheung Y.N., Takacs J.E., Martin-Marcos P., Saini A.K., Hinnebusch A.G., Lorsch J.R.
J. Mol. Biol. 394:268-285(2009) · Mapped (68) |
| Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation. Dev K., Santangelo T.J., Rothenburg S., Neculai D., Dey M., Sicheri F., Dever T.E., Reeve J.N., Hinnebusch A.G.
J. Mol. Biol. 392:701-722(2009) · Mapped (7) |
| Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p. Moxley J.F., Jewett M.C., Antoniewicz M.R., Villas-Boas S.G., Alper H., Wheeler R.T., Tong L., Hinnebusch A.G., Ideker T., Nielsen J. et al.
Proc. Natl. Acad. Sci. U.S.A. 106:6477-6482(2009) · Mapped (5) |
| Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters. Qiu H., Hu C., Hinnebusch A.G.
Mol. Cell 33:752-762(2009) · Mapped (12) |
| Mcm1p binding sites in ARG1 positively regulate Gcn4p binding and SWI/SNF recruitment. Yoon S., Hinnebusch A.G.
Biochem. Biophys. Res. Commun. 381:123-128(2009) · Mapped (10) |
| A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2. Garriz A., Qiu H., Dey M., Seo E.J., Dever T.E., Hinnebusch A.G.
Mol. Cell. Biol. 29:1592-1607(2009) · Mapped (2) |
| Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2. Pascual-Garcia P., Govind C.K., Queralt E., Cuenca-Bono B., Llopis A., Chavez S., Hinnebusch A.G., Rodriguez-Navarro S.
Genes Dev. 22:2811-2822(2008) · UniProtKB (1) · Mapped (16) |
| Disrupting vesicular trafficking at the endosome attenuates transcriptional activation by Gcn4. Zhang F., Gaur N.A., Hasek J., Kim S.J., Qiu H., Swanson M.J., Hinnebusch A.G.
Mol. Cell. Biol. 28:6796-6818(2008) · Mapped (24) |
| eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA. Szamecz B., Rutkai E., Cuchalova L., Munzarova V., Herrmannova A., Nielsen K.H., Burela L., Hinnebusch A.G., Valasek L.
Genes Dev. 22:2414-2425(2008) · UniProtKB (1) · Mapped (1) |
| Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection. Dong J., Nanda J.S., Rahman H., Pruitt M.R., Shin B.S., Wong C.M., Lorsch J.R., Hinnebusch A.G.
Genes Dev. 22:2242-2255(2008) · Mapped (1) |
