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On terminal alkynes that can react with active-site cysteine nucleophiles in proteases.

Ekkebus R., van Kasteren S.I., Kulathu Y., Scholten A., Berlin I., Geurink P.P., de Jong A., Goerdayal S., Neefjes J., Heck A.J. et al.

J. Am. Chem. Soc. 135:2867-2870(2013) · Mapped (2)

A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane.

Burgers P.P., Ma Y., Margarucci L., Mackey M., van der Heyden M.A., Ellisman M., Scholten A., Taylor S.S., Heck A.J.

J. Biol. Chem. 287:43789-43797(2012) · UniProtKB (4)

Precursor of ether phospholipids is synthesized by a flavoenzyme through covalent catalysis.

Nenci S., Piano V., Rosati S., Aliverti A., Pandini V., Fraaije M.W., Heck A.J., Edmondson D.E., Mattevi A.

Proc. Natl. Acad. Sci. U.S.A. 109:18791-18796(2012) · UniProtKB (1)

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

Koo B.K., Spit M., Jordens I., Low T.Y., Stange D.E., van de Wetering M., van Es J.H., Mohammed S., Heck A.J., Maurice M.M. et al.

Nature 488:665-669(2012) · UniProtKB (4) · Mapped (8)

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.

Munoz J., Stange D.E., Schepers A.G., van de Wetering M., Koo B.K., Itzkovitz S., Volckmann R., Kung K.S., Koster J., Radulescu S. et al.

EMBO J. 31:3079-3091(2012) · Mapped (4)

Wnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex.

Li V.S., Ng S.S., Boersema P.J., Low T.Y., Karthaus W.R., Gerlach J.P., Mohammed S., Heck A.J., Maurice M.M., Mahmoudi T. et al.

Cell 149:1245-1256(2012) · Mapped (15)

Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth.

Blattner C., Jennebach S., Herzog F., Mayer A., Cheung A.C., Witte G., Lorenzen K., Hopfner K.P., Heck A.J., Aebersold R. et al.

Genes Dev. 25:2093-2105(2011) · UniProtKB (1) · Mapped (9)

aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.

Galli M., Munoz J., Portegijs V., Boxem M., Grill S.W., Heck A.J., van den Heuvel S.

Nat. Cell Biol. 13:1132-1138(2011) · Mapped (10)

Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes.

Garcia-Alles L.F., Giacometti G., Versluis C., Maveyraud L., de Paepe D., Guiard J., Tranier S., Gilleron M., Prandi J., Hanau D. et al.

Proc. Natl. Acad. Sci. U.S.A. 108:13230-13235(2011) · Mapped (10)

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

de Lau W., Barker N., Low T.Y., Koo B.K., Li V.S., Teunissen H., Kujala P., Haegebarth A., Peters P.J., van de Wetering M. et al.

Nature 476:293-297(2011) · Mapped (18)

RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions.

Wiedenheft B., van Duijn E., Bultema J.B., Waghmare S.P., Zhou K., Barendregt A., Westphal W., Heck A.J., Boekema E.J., Dickman M.J. et al.

Proc. Natl. Acad. Sci. U.S.A. 108:10092-10097(2011) · UniProtKB (4)

Structural basis for CRISPR RNA-guided DNA recognition by Cascade.

Jore M.M., Lundgren M., van Duijn E., Bultema J.B., Westra E.R., Waghmare S.P., Wiedenheft B., Pul U., Wurm R., Wagner R. et al.

Nat. Struct. Mol. Biol. 18:529-536(2011) · UniProtKB (5)

Protein signatures associated with tumor cell dissemination in head and neck cancer.

Bleijerveld O.B., Brakenhoff R.H., Schaaij-Visser T.B., Damen J.M., Altelaar A.F., Heck A.J., Leemans C.R., Slijper M.

J Proteomics 74:558-566(2011) · Mapped (1)

N-terminal domain of human Hsp90 triggers binding to the cochaperone p23.

Karagoz G.E., Duarte A.M., Ippel H., Uetrecht C., Sinnige T., van Rosmalen M., Hausmann J., Heck A.J., Boelens R., Rudiger S.G.

Proc. Natl. Acad. Sci. U.S.A. 108:580-585(2011) · Mapped (15)

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/beta-catenin coactivators essential for intestinal homeostasis.

Mahmoudi T., Boj S.F., Hatzis P., Li V.S., Taouatas N., Vries R.G., Teunissen H., Begthel H., Korving J., Mohammed S. et al.

PLoS Biol. 8:e1000539-e1000539(2010) · Mapped (54)

RNA polymerase I contains a TFIIF-related DNA-binding subcomplex.

Geiger S.R., Lorenzen K., Schreieck A., Hanecker P., Kostrewa D., Heck A.J., Cramer P.

Mol. Cell 39:583-594(2010) · UniProtKB (2) · Mapped (3)

Dis3-like 1: a novel exoribonuclease associated with the human exosome.

Staals R.H., Bronkhorst A.W., Schilders G., Slomovic S., Schuster G., Heck A.J., Raijmakers R., Pruijn G.J.

EMBO J. 29:2358-2367(2010) · UniProtKB (13) · Mapped (3)

Crystal structure of bovine CD1b3 with endogenously bound ligands.

Girardi E., Wang J., Mac T.T., Versluis C., Bhowruth V., Besra G., Heck A.J., Van Rhijn I., Zajonc D.M.

J. Immunol. 185:376-386(2010) · UniProtKB (2) · Mapped (1)

Identification of Pep4p as the protease responsible for formation of the SAGA-related SLIK protein complex.

Spedale G., Mischerikow N., Heck A.J., Timmers H.T., Pijnappel W.W.

J. Biol. Chem. 285:22793-22799(2010) · Mapped (6)

A role for BAF57 in cell cycle-dependent transcriptional regulation by the SWI/SNF chromatin remodeling complex.

Hah N., Kolkman A., Ruhl D.D., Pijnappel W.W., Heck A.J., Timmers H.T., Kraus W.L.

Cancer Res. 70:4402-4411(2010) · Mapped (7)

Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase.

Kovanich D., van der Heyden M.A., Aye T.T., van Veen T.A., Heck A.J., Scholten A.

ChemBioChem 11:963-971(2010) · UniProtKB (1) · Mapped (1)

Phosphorylation of Not4p functions parallel to BUR2 to regulate resistance to cellular stresses in Saccharomyces cerevisiae.

Lau N.C., Mulder K.W., Brenkman A.B., Mohammed S., van den Broek N.J., Heck A.J., Timmers H.T.

PLoS ONE 5:e9864-e9864(2010) · Mapped (11)

Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1.

Alvarez-Fernandez M., Halim V.A., Krenning L., Aprelia M., Mohammed S., Heck A.J., Medema R.H.

EMBO Rep. 11:452-458(2010) · Mapped (3)

MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.

Sue Ng S., Mahmoudi T., Li V.S., Hatzis P., Boersema P.J., Mohammed S., Heck A.J., Clevers H.

Biol. Chem. 391:171-180(2010) · Mapped (3)

Preparation and topology of the Mediator middle module.

Koschubs T., Lorenzen K., Baumli S., Sandstrom S., Heck A.J., Cramer P.

Nucleic Acids Res. 38:3186-3195(2010) · Mapped (7)

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