9 results for author:"Hargreaves D." in Literature citations
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| Discovery of a potent, selective, and orally bioavailable acidic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017). Scott J.S., Bowker S.S., Deschoolmeester J., Gerhardt S., Hargreaves D., Kilgour E., Lloyd A., Mayers R.M., McCoull W., Newcombe N.J. et al. J. Med. Chem. 55:5951-5964(2012) · Mapped (1) |
| Selective non zinc binding inhibitors of MMP13. De Savi C., Morley A.D., Ting A., Nash I., Karabelas K., Wood C.M., James M., Norris S.J., Karoutchi G., Rankine N. et al. Bioorg. Med. Chem. Lett. 21:4215-4219(2011) · Mapped (1) |
| Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an alpha-helix in VH CDR3 as key component of paratope. Lowe D.C., Gerhardt S., Ward A., Hargreaves D., Anderson M., Ferraro F., Pauptit R.A., Pattison D.V., Buchanan C., Popovic B. et al. J. Mol. Biol. 406:160-175(2011) · Mapped (1) |
| Structure of IL-17A in complex with a potent, fully human neutralizing antibody. Gerhardt S., Abbott W.M., Hargreaves D., Pauptit R.A., Davies R.A., Needham M.R., Langham C., Barker W., Aziz A., Snow M.J. et al. J. Mol. Biol. 394:905-921(2009) · UniProtKB (1) · Mapped (2) |
| Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains. Gerhardt S., Hassall G., Hawtin P., McCall E., Flavell L., Minshull C., Hargreaves D., Ting A., Pauptit R.A., Parker A.E. et al. J. Mol. Biol. 373:891-902(2007) · Mapped (5) |
| Structural and functional analysis of the kid toxin protein from E. coli plasmid R1. Hargreaves D., Santos-Sierra S., Giraldo R., Sabariegos-Jareno R., de la Cueva-Mendez G., Boelens R., Diaz-Orejas R., Rafferty J.B. Structure 10:1425-1433(2002) · UniProtKB (1) |
| Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. Luther S.A., Bidgol A., Hargreaves D.C., Schmidt A., Xu Y., Paniyadi J., Matloubian M., Cyster J.G. J. Immunol. 169:424-433(2002) · Mapped (2) |
| Crystal structure of E.coli RuvA with bound DNA Holliday junction at 6-A resolution. Hargreaves D., Rice D.W., Sedelnikova S.E., Artymiuk P.J., Lloyd R.G., Rafferty J.B. Nat. Struct. Biol. 5:441-446(1998) · UniProtKB (1) |
| Crystal structure of DNA recombination protein RuvA and a model for its binding to the Holliday junction. Rafferty J.B., Sedelnikova S.E., Hargreaves D., Artymiuk P.J., Baker P.J., Sharples G.J., Mahdi A.A., Lloyd R.G., Rice D.W. Science 274:415-421(1996) · UniProtKB (1) |