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Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.

Kakefuda K., Fujita Y., Oyagi A., Hyakkoku K., Kojima T., Umemura K., Tsuruma K., Shimazawa M., Ito M., Nozawa Y. et al.

Biochem. Biophys. Res. Commun. 387:784-788(2009) · Mapped (4)

Amelioration of experimental allergic rhinitis with suppression of topical immune responses by lack of IL-27/WSX-1 signaling.

Shimanoe Y., Miyazaki Y., Hara H., Inokuchi A., Yoshida H.

Ann. Allergy Asthma Immunol. 102:223-232(2009) · Mapped (2)

Involvement of PlsX and the acyl-phosphate dependent sn-glycerol-3-phosphate acyltransferase PlsY in the initial stage of glycerolipid synthesis in Bacillus subtilis.

Hara Y., Seki M., Matsuoka S., Hara H., Yamashita A., Matsumoto K.

Genes Genet. Syst. 83:433-442(2008) · UniProtKB (2)

A systematic evaluation of the function of the protein-remodeling factor Hsp104 in [PSI+] prion propagation in S. cerevisiae by comprehensive chromosomal mutations.

Takahashi A., Hara H., Kurahashi H., Nakamura Y.

Prion 1:69-77(2007) · Mapped (3)

Molecular basis for SUMOylation-dependent regulation of DNA binding activity of heat shock factor 2.

Tateishi Y., Ariyoshi M., Igarashi R., Hara H., Mizuguchi K., Seto A., Nakai A., Kokubo T., Tochio H., Shirakawa M.

J. Biol. Chem. 284:2435-2447(2009) · Mapped (4)

A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N-methyl-D-aspartate injection and ischemia-reperfusion.

Inokuchi Y., Shimazawa M., Nakajima Y., Komuro I., Matsuda T., Baba A., Araie M., Kita S., Iwamoto T., Hara H.

J. Neurosci. Res. 87:906-917(2009) · Mapped (15)

Reduced expression of sarcospan in muscles of Fukuyama congenital muscular dystrophy.

Wakayama Y., Inoue M., Kojima H., Yamashita S., Shibuya S., Jimi T., Hara H., Matsuzaki Y., Oniki H., Kanagawa M. et al.

Histol. Histopathol. 23:1425-1438(2008) · Mapped (6)

Mincle is an ITAM-coupled activating receptor that senses damaged cells.

Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T.

Nat. Immunol. 9:1179-1188(2008) · Mapped (18)

Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling.

Shimazawa M., Inokuchi Y., Okuno T., Nakajima Y., Sakaguchi G., Kato A., Oku H., Sugiyama T., Kudo T., Ikeda T. et al.

J. Neurochem. 107:279-290(2008) · Mapped (3)

Aquaporin 4 mRNA levels in neuromuscular tissues of wild-type and dystrophin-deficient mice.

Shibuya S., Hara H., Wakayama Y., Inoue M., Jimi T., Matsuzaki Y.

Tohoku J. Exp. Med. 215:313-319(2008) · Mapped (5)

Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9.

Hara H., Ishihara C., Takeuchi A., Xue L., Morris S.W., Penninger J.M., Yoshida H., Saito T.

J. Immunol. 181:918-930(2008) · Mapped (63)

Dependency of caspase-1 activation induced in macrophages by Listeria monocytogenes on cytolysin, listeriolysin O, after evasion from phagosome into the cytoplasm.

Hara H., Tsuchiya K., Nomura T., Kawamura I., Shoma S., Mitsuyama M.

J. Immunol. 180:7859-7868(2008) · Mapped (6)

Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.

Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.

J. Bacteriol. 190:4050-4060(2008) · UniProtKB (7,008)

Novel hierarchical classification and visualization method for multiobjective optimization of drug properties: application to structure-activity relationship analysis of cytochrome P450 metabolism.

Yamashita F., Hara H., Ito T., Hashida M.

J Chem Inf Model 48:364-369(2008) · Mapped (45)

Critical involvement of pneumolysin in production of interleukin-1alpha and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: a novel function of pneumolysin in caspase-1 activation.

Shoma S., Tsuchiya K., Kawamura I., Nomura T., Hara H., Uchiyama R., Daim S., Mitsuyama M.

Infect. Immun. 76:1547-1557(2008) · Mapped (1)

A molecular chaperone inducer protects neurons from ER stress.

Kudo T., Kanemoto S., Hara H., Morimoto N., Morihara T., Kimura R., Tabira T., Imaizumi K., Takeda M.

Cell Death Differ. 15:364-375(2008) · Mapped (4)

Structural analysis of the phototactic transducer protein HtrII linker region from Natronomonas pharaonis.

Hayashi K., Sudo Y., Jee J., Mishima M., Hara H., Kamo N., Kojima C.

Biochemistry 46:14380-14390(2007) · Mapped (1)

Characterization of ligV essential for catabolism of vanillin by Sphingomonas paucimobilis SYK-6.

Masai E., Yamamoto Y., Inoue T., Takamura K., Hara H., Kasai D., Katayama Y., Fukuda M.

Biosci. Biotechnol. Biochem. 71:2487-2492(2007) · UniProtKB (4)

The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers.

Zhang L., Anglesio M.S., O'Sullivan M., Zhang F., Yang G., Sarao R., Mai P.N., Cronin S., Hara H., Melnyk N. et al.

Nat. Med. 13:1060-1069(2007) · Mapped (22)

Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload.

Kuba K., Zhang L., Imai Y., Arab S., Chen M., Maekawa Y., Leschnik M., Leibbrandt A., Markovic M., Makovic M. et al.

Circ. Res. 101:e32-42(2007) · Mapped (2)

Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage.

Shimazawa M., Ito Y., Inokuchi Y., Hara H.

Invest. Ophthalmol. Vis. Sci. 48:3729-3736(2007) · Mapped (5)

Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia.

Wakida K., Shimazawa M., Hozumi I., Satoh M., Nagase H., Inuzuka T., Hara H.

Neuroscience 148:105-114(2007) · Mapped (4)

Interleukin-18 regulates T helper 1 or 2 immune responses of human cord blood CD4+ V alpha 24+V beta 11+ natural killer T cells.

Fujibayashi Y., Fujimori Y., Kasumoto I., Kai S., Hara H., Okamura H., Tsutsui H., Ogawa H., Nakanishi K.

Int. J. Mol. Med. 20:241-245(2007) · Mapped (4)

Cutting edge: TLR2 directly triggers Th1 effector functions.

Imanishi T., Hara H., Suzuki S., Suzuki N., Akira S., Saito T.

J. Immunol. 178:6715-6719(2007) · Mapped (3)

The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.

Hara H., Ishihara C., Takeuchi A., Imanishi T., Xue L., Morris S.W., Inui M., Takai T., Shibuya A., Saijo S. et al.

Nat. Immunol. 8:619-629(2007) · Mapped (16)

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