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Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.

Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.

Science 325:1682-1686(2009) · Mapped (3)

Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.

Kajimura S., Seale P., Kubota K., Lunsford E., Frangioni J.V., Gygi S.P., Spiegelman B.M.

Nature 460:1154-1158(2009) · UniProtKB (4) · Mapped (59)

SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.

Hao H.-X., Khalimonchuk O., Schraders M., Dephoure N., Bayley J.-P., Kunst H., Devilee P., Cremers C.W.R.J., Schiffman J.D., Bentz B.G. et al.

Science 325:1139-1142(2009) · UniProtKB (4) · Mapped (1)

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.

Svendsen J.M., Smogorzewska A., Sowa M.E., O'Connell B.C., Gygi S.P., Elledge S.J., Harper J.W.

Cell 138:63-77(2009) · UniProtKB (9) · Mapped (2)

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.

Xie L., Xiao K., Whalen E.J., Forrester M.T., Freeman R.S., Fong G., Gygi S.P., Lefkowitz R.J., Stamler J.S.

Sci Signal 2:ra33-ra33(2009) · Mapped (8)

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes.

Bastiani M., Liu L., Hill M.M., Jedrychowski M.P., Nixon S.J., Lo H.P., Abankwa D., Luetterforst R., Fernandez-Rojo M., Breen M.R. et al.

J. Cell Biol. 185:1259-1273(2009) · Mapped (4)

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.

Cohen S., Brault J.J., Gygi S.P., Glass D.J., Valenzuela D.M., Gartner C., Latres E., Goldberg A.L.

J. Cell Biol. 185:1083-1095(2009) · Mapped (4)

GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation.

Kelly T.J., Lerin C., Haas W., Gygi S.P., Puigserver P.

J. Biol. Chem. 284:19945-19952(2009) · Mapped (1)

Hexameric assembly of the proteasomal ATPases is templated through their C termini.

Park S., Roelofs J., Kim W., Robert J., Schmidt M., Gygi S.P., Finley D.

Nature 459:866-870(2009) · Mapped (8)

Chaperone-mediated pathway of proteasome regulatory particle assembly.

Roelofs J., Park S., Haas W., Tian G., McAllister F.E., Huo Y., Lee B.H., Zhang F., Shi Y., Gygi S.P. et al.

Nature 459:861-865(2009) · Mapped (16)

S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.

Kim H.T., Kim K.P., Uchiki T., Gygi S.P., Goldberg A.L.

EMBO J. 28:1867-1877(2009) · Mapped (6)

A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export.

Hurt J.A., Obar R.A., Zhai B., Farny N.G., Gygi S.P., Silver P.A.

J. Cell Biol. 185:265-277(2009) · Mapped (21)

p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling.

Abe Y., Yoon S.O., Kubota K., Mendoza M.C., Gygi S.P., Blenis J.

J. Biol. Chem. 284:14939-14948(2009) · Mapped (15)

UAF1 is a subunit of multiple deubiquitinating enzyme complexes.

Cohn M.A., Kee Y., Haas W., Gygi S.P., D'Andrea A.D.

J. Biol. Chem. 284:5343-5351(2009) · UniProtKB (3)

Role for perinuclear chromosome tethering in maintenance of genome stability.

Mekhail K., Seebacher J., Gygi S.P., Moazed D.

Nature 456:667-670(2008) · Mapped (10)

Extraproteasomal Rpn10 restricts access of the polyubiquitin-binding protein Dsk2 to proteasome.

Matiuhin Y., Kirkpatrick D.S., Ziv I., Kim W., Dakshinamurthy A., Kleifeld O., Gygi S.P., Reis N., Glickman M.H.

Mol. Cell 32:415-425(2008) · Mapped (5)

Mass spectrometric analysis of type 1 inositol 1,4,5-trisphosphate receptor ubiquitination.

Sliter D.A., Kubota K., Kirkpatrick D.S., Alzayady K.J., Gygi S.P., Wojcikiewicz R.J.

J. Biol. Chem. 283:35319-35328(2008) · Mapped (1)

Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis.

Pearce M.J., Mintseris J., Ferreyra J., Gygi S.P., Darwin K.H.

Science 322:1104-1107(2008) · UniProtKB (4)

Unphosphorylated SR-like protein Npl3 stimulates RNA polymerase II elongation.

Dermody J.L., Dreyfuss J.M., Villen J., Ogundipe B., Gygi S.P., Park P.J., Ponticelli A.S., Moore C.L., Buratowski S., Bucheli M.E.

PLoS ONE 3:e3273-e3273(2008) · Mapped (5)

An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.

Xu L., Sowa M.E., Chen J., Li X., Gygi S.P., Harper J.W.

Mol. Biol. Cell 19:5059-5071(2008) · UniProtKB (5) · Mapped (6)

Sir3-nucleosome interactions in spreading of silent chromatin in Saccharomyces cerevisiae.

Buchberger J.R., Onishi M., Li G., Seebacher J., Rudner A.D., Gygi S.P., Moazed D.

Mol. Cell. Biol. 28:6903-6918(2008) · Mapped (7)

A quantitative atlas of mitotic phosphorylation.

Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.

Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) · UniProtKB (3,017)

A molecular determinant for the establishment of sister chromatid cohesion.

Unal E., Heidinger-Pauli J.M., Kim W., Guacci V., Onn I., Gygi S.P., Koshland D.E.

Science 321:566-569(2008) · Mapped (2)

Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.

Monahan B.J., Villen J., Marguerat S., Baehler J., Gygi S.P., Winston F.

Nat. Struct. Mol. Biol. 15:873-880(2008) · UniProtKB (19) · Mapped (8)

Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome.

Menetret J.F., Hegde R.S., Aguiar M., Gygi S.P., Park E., Rapoport T.A., Akey C.W.

Structure 16:1126-1137(2008) · Mapped (3)

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