1 - 25 of 58 results for author:"Groll M." in Literature citations
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| Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites. Geurink P.P., van der Linden W.A., Mirabella A.C., Gallastegui N., de Bruin G., Blom A.E., Voges M.J., Mock E.D., Florea B.I., van der Marel G.A. et al. J. Med. Chem. 56:1262-1275(2013) · Mapped (14) |
| Structures of fluoro, amino, and thiol inhibitors bound to the [Fe4S4] protein IspH. Span I., Wang K., Wang W., Jauch J., Eisenreich W., Bacher A., Oldfield E., Groll M. Angew. Chem. Int. Ed. Engl. 52:2118-2121(2013) · Mapped (1) |
| Alternative bacterial two-component small heat shock protein systems. Bepperling A., Alte F., Kriehuber T., Braun N., Weinkauf S., Groll M., Haslbeck M., Buchner J. Proc. Natl. Acad. Sci. U.S.A. 109:20407-20412(2012) · UniProtKB (1) |
| One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor. Stein M.L., Beck P., Kaiser M., Dudler R., Becker C.F., Groll M. Proc. Natl. Acad. Sci. U.S.A. 109:18367-18371(2012) · Mapped (14) |
| Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution. Quitterer F., List A., Beck P., Bacher A., Groll M. J. Mol. Biol. 424:270-282(2012) · UniProtKB (1) |
| Discovery of acetylene hydratase activity of the iron-sulphur protein IspH. Span I., Wang K., Wang W., Zhang Y., Bacher A., Eisenreich W., Li K., Schulz C., Oldfield E., Groll M. Nat Commun 3:1042-1042(2012) · Mapped (1) |
| DNA minor groove sensing and widening by the CCAAT-binding complex. Huber E.M., Scharf D.H., Hortschansky P., Groll M., Brakhage A.A. Structure 20:1757-1768(2012) · UniProtKB (3) |
| Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells. Archer C.R., Groll M., Stein M.L., Schellenberg B., Clerc J., Kaiser M., Kondratyuk T.P., Pezzuto J.M., Dudler R., Bachmann A.S. Biochemistry 51:6880-6888(2012) · Mapped (14) |
| Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation. Wang W., Wang K., Span I., Jauch J., Bacher A., Groll M., Oldfield E. J. Am. Chem. Soc. 134:11225-11234(2012) · Mapped (1) |
| Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity. Huber E.M., Basler M., Schwab R., Heinemeyer W., Kirk C.J., Groettrup M., Groll M. Cell 148:727-738(2012) · Mapped (34) |
| Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein. Gersch M., List A., Groll M., Sieber S.A. J. Biol. Chem. 287:9484-9494(2012) · Mapped (1) |
| The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop. Schmid A.B., Lagleder S., Grawert M.A., Rohl A., Hagn F., Wandinger S.K., Cox M.B., Demmer O., Richter K., Groll M. et al. EMBO J. 31:1506-1517(2012) · Mapped (2) |
| Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis. Span I., Graewert T., Bacher A., Eisenreich W., Groll M. J. Mol. Biol. 416:1-9(2012) · UniProtKB (1) |
| Hydroxyureas as noncovalent proteasome inhibitors. Gallastegui N., Beck P., Arciniega M., Huber R., Hillebrand S., Groll M. Angew. Chem. Int. Ed. Engl. 51:247-249(2012) · Mapped (14) |
| Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis. Quitterer F., List A., Eisenreich W., Bacher A., Groll M. Angew. Chem. Int. Ed. 51:1339-1342(2012) · UniProtKB (1) |
| Synthesis and biological activity of optimized belactosin C congeners. Korotkov V.S., Ludwig A., Larionov O.V., Lygin A.V., Groll M., de Meijere A. Org. Biomol. Chem. 9:7791-7798(2011) · Mapped (14) |
| Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr). Behrendt C.T., Kunfermann A., Illarionova V., Matheeussen A., Pein M.K., Grawert T., Kaiser J., Bacher A., Eisenreich W., Illarionov B. et al. J. Med. Chem. 54:6796-6802(2011) · Mapped (1) |
| Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition. Grawert M.A., Gallastegui N., Stein M., Schmidt B., Kloetzel P.M., Huber R., Groll M. Angew. Chem. Int. Ed. Engl. 50:542-544(2011) · Mapped (14) |
| Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner. Alte F., Stengel A., Benz J.P., Petersen E., Soll J., Groll M., Bolter B. Proc. Natl. Acad. Sci. U.S.A. 107:19260-19265(2010) · UniProtKB (1) · Mapped (1) |
| Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG. Lee M., Graewert T., Quitterer F., Rohdich F., Eppinger J., Eisenreich W., Bacher A., Groll M. J. Mol. Biol. 404:600-610(2010) · UniProtKB (1) |
| 20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A. Groll M., Gallastegui N., Marechal X., Le Ravalec V., Basse N., Richy N., Genin E., Huber R., Moroder L., Vidal J. et al. ChemMedChem 5:1701-1705(2010) · Mapped (14) |
| Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum. Geist J.G., Lauw S., Illarionova V., Illarionov B., Fischer M., Grawert T., Rohdich F., Eisenreich W., Kaiser J., Groll M. et al. ChemMedChem 5:1092-1101(2010) |
| Probing the reaction mechanism of IspH protein by x-ray structure analysis. Graewert T., Span I., Eisenreich W., Rohdich F., Eppinger J., Bacher A., Groll M. Proc. Natl. Acad. Sci. U.S.A. 107:1077-1081(2010) · UniProtKB (1) |
| Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition. Groll M., McArthur K.A., Macherla V.R., Manam R.R., Potts B.C. J. Med. Chem. 52:5420-5428(2009) · Mapped (14) |
| Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction. Graewert T., Rohdich F., Span I., Bacher A., Eisenreich W., Eppinger J., Groll M. Angew. Chem. Int. Ed. Engl. 48:5756-5759(2009) · UniProtKB (1) |