1 - 25 of 66 results for author:"Garcia K.C." in Literature citations
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| Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Ring A.M., Lin J.X., Feng D., Mitra S., Rickert M., Bowman G.R., Pande V.S., Li P., Moraga I., Spolski R. et al. Nat. Immunol. 13:1187-1195(2012) · Mapped (16) |
| Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines. Junttila I.S., Creusot R.J., Moraga I., Bates D.L., Wong M.T., Alonso M.N., Suhoski M.M., Lupardus P., Meier-Schellersheim M., Engleman E.G. et al. Nat. Chem. Biol. 8:990-998(2012) · Mapped (2) |
| Structural basis of Wnt recognition by Frizzled. Janda C.Y., Waghray D., Levin A.M., Thomas C., Garcia K.C. Science 337:59-64(2012) · UniProtKB (2) |
| Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Levin A.M., Bates D.L., Ring A.M., Krieg C., Lin J.T., Su L., Moraga I., Raeber M.E., Bowman G.R., Novick P. et al. Nature 484:529-533(2012) · Mapped (15) |
| Structure of the activating IL-1 receptor signaling complex. Thomas C., Bazan J.F., Garcia K.C. Nat. Struct. Mol. Biol. 19:455-457(2012) · Mapped (5) |
| The composition and signaling of the IL-35 receptor are unconventional. Collison L.W., Delgoffe G.M., Guy C.S., Vignali K.M., Chaturvedi V., Fairweather D., Satoskar A.R., Garcia K.C., Hunter C.A., Drake C.G. et al. Nat. Immunol. 13:290-299(2012) · Mapped (39) |
| Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting. Sweeney L.B., Chou Y.H., Wu Z., Joo W., Komiyama T., Potter C.J., Kolodkin A.L., Garcia K.C., Luo L. Neuron 72:734-747(2011) · Mapped (28) |
| T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Adams J.J., Narayanan S., Liu B., Birnbaum M.E., Kruse A.C., Bowerman N.A., Chen W., Levin A.M., Connolly J.M., Zhu C. et al. Immunity 35:681-693(2011) · Mapped (2) |
| Structural linkage between ligand discrimination and receptor activation by type I interferons. Thomas C., Moraga I., Levin D., Krutzik P.O., Podoplelova Y., Trejo A., Lee C., Yarden G., Vleck S.E., Glenn J.S. et al. |
| Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k). Newell E.W., Ely L.K., Kruse A.C., Reay P.A., Rodriguez S.N., Lin A.E., Kuhns M.S., Garcia K.C., Davis M.M. J. Immunol. 186:5823-5832(2011) · Mapped (3) |
| Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins. Shen A., Lupardus P.J., Gersch M.M., Puri A.W., Albrow V.E., Garcia K.C., Bogyo M. Nat. Struct. Mol. Biol. 18:364-371(2011) · UniProtKB (1) |
| Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Ralpha cytokine receptor complex, and the receptor-Jak1 holocomplex. Lupardus P.J., Skiniotis G., Rice A.J., Thomas C., Fischer S., Walz T., Garcia K.C. Structure 19:45-55(2011) · Mapped (14) |
| Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires. Gleimer M., Wahl A.R., Hickman H.D., Abi-Rached L., Norman P.J., Guethlein L.A., Hammond J.A., Draghi M., Adams E.J., Juo S. et al. J. Immunol. 186:1575-1588(2011) · UniProtKB (1) |
| Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB. Puri A.W., Lupardus P.J., Deu E., Albrow V.E., Garcia K.C., Bogyo M., Shen A. Chem. Biol. 17:1201-1211(2010) · UniProtKB (1) |
| Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. Liu H., Juo Z.S., Shim A.H., Focia P.J., Chen X., Garcia K.C., He X. |
| Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Lupardus P.J., Birnbaum M.E., Garcia K.C. Structure 18:332-342(2010) · UniProtKB (2) |
| Molecular and structural insight into proNGF engagement of p75NTR and sortilin. Feng D., Kim T., Ozkan E., Light M., Torkin R., Teng K.K., Hempstead B.L., Garcia K.C. J. Mol. Biol. 396:967-984(2010) · Mapped (8) |
| Structural basis of receptor sharing by interleukin 17 cytokines. Ely L.K., Fischer S., Garcia K.C. Nat. Immunol. 10:1245-1251(2009) · UniProtKB (2) · Mapped (4) |
| Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Eroglu C., Allen N.J., Susman M.W., O'Rourke N.A., Park C.Y., Ozkan E., Chakraborty C., Mulinyawe S.B., Annis D.S., Huberman A.D. et al. Cell 139:380-392(2009) · Mapped (9) |
| Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness. Ito T., Suzuki S., Kanaji S., Shiraishi H., Ohta S., Arima K., Tanaka G., Tamada T., Honjo E., Garcia K.C. et al. J. Biol. Chem. 284:24289-24296(2009) · Mapped (19) |
| Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin. Shen A., Lupardus P.J., Albrow V.E., Guzzetta A., Powers J.C., Garcia K.C., Bogyo M. Nat. Chem. Biol. 5:469-478(2009) · UniProtKB (1) |
| IL1B polymorphisms modulate cystic fibrosis lung disease. Levy H., Murphy A., Zou F., Gerard C., Klanderman B., Schuemann B., Lazarus R., Garcia K.C., Celedon J.C., Drumm M. et al. Pediatr. Pulmonol. 44:580-593(2009) · Mapped (11) |
| STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Park C.Y., Hoover P.J., Mullins F.M., Bachhawat P., Covington E.D., Raunser S., Walz T., Garcia K.C., Dolmetsch R.E., Lewis R.S. Cell 136:876-890(2009) · Mapped (3) |
| Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors. Jones L.L., Colf L.A., Bankovich A.J., Stone J.D., Gao Y.G., Chan C.M., Huang R.H., Garcia K.C., Kranz D.M. Biochemistry 47:12398-12408(2008) · UniProtKB (1) |
| Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation. Jones L.L., Colf L.A., Stone J.D., Garcia K.C., Kranz D.M. J. Immunol. 181:6255-6264(2008) · UniProtKB (1) · Mapped (2) |