| Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate. Cody V., Galitsky N., Luft J.R., Pangborn W., Gangjee A., Devraj R., Queener S.F., Blakley R.L.
Acta Crystallogr. D Biol. Crystallogr. 53:638-649(1997) · Mapped (1) |
| Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase. Cody V., Galitsky N., Luft J.R., Pangborn W., Gangjee A.
Acta Crystallogr. D 59:654-661(2003) · UniProtKB (1) |
| Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase. Cody V., Galitsky N., Luft J.R., Pangborn W., Queener S.F., Gangjee A.
Acta Crystallogr. D 58:1393-1399(2002) · UniProtKB (1) |
| Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH. Cody V., Galitsky N., Luft J.R., Pangborn W., Rosowsky A., Queener S.F.
Acta Crystallogr. D 58:946-954(2002) · UniProtKB (1) |
| Structure of the insecticidal bacterial delta-endotoxin Cry3Bb1 of Bacillus thuringiensis. Galitsky N., Cody V., Wojtczak A., Ghosh D., Luft J.R., Pangborn W., English L.
Acta Crystallogr. D Biol. Crystallogr. 57:1101-1109(2001) · Mapped (1) |
| Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate. Cody V., Chan D., Galitsky N., Rak D., Luft J.R., Pangborn W., Queener S.F., Laughton C.A., Stevens M.F.
Biochemistry 39:3556-3564(2000) · UniProtKB (1) |
| Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+. Cody V., Galitsky N., Rak D., Luft J.R., Pangborn W., Queener S.F.
Biochemistry 38:4303-4312(1999) · UniProtKB (1) |
| Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents. Gangjee A., Vidwans A.P., Vasudevan A., Queener S.F., Kisliuk R.L., Cody V., Li R., Galitsky N., Luft J.R., Pangborn W.
J. Med. Chem. 41:3426-3434(1998) · UniProtKB (1) |
| Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine. Cody V., Galitsky N., Luft J.R., Pangborn W., Blakley R.L., Gangjee A.
Anticancer Drug Des. 13:307-315(1998) · Mapped (1) |
| Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523. Cody V., Galitsky N., Luft J.R., Pangborn W., Blakley R.L., Gangjee A.
Biochemistry 36:13897-13903(1997) · UniProtKB (1) |
| Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers. Lewis W.S., Cody V., Galitsky N., Luft J.R., Pangborn W., Chunduru S.K., Spencer H.T., Appleman J.R., Blakley R.L.
J. Biol. Chem. 270:5057-5064(1995) · UniProtKB (1) |
