| RIP1 protein-dependent assembly of a cytosolic cell death complex is required for inhibitor of apoptosis (IAP) inhibitor-mediated sensitization to lexatumumab-induced apoptosis. Basit F., Humphreys R., Fulda S.
J. Biol. Chem. 287:38767-38777(2012) · Mapped (10) |
| Survivin as a prognostic/predictive marker and molecular target in cancer therapy. Rodel F., Sprenger T., Kaina B., Liersch T., Rodel C., Fulda S., Hehlgans S.
Curr. Med. Chem. 19:3679-3688(2012) · Mapped (9) |
| Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP. Bangert A., Cristofanon S., Eckhardt I., Abhari B.A., Kolodziej S., Hacker S., Vellanki S.H., Lausen J., Debatin K.M., Fulda S.
Oncogene 31:4677-4688(2012) |
| Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro. Huber-Lang M., Denk S., Fulda S., Erler E., Kalbitz M., Weckbach S., Schneider E.M., Weiss M., Kanse S.M., Perl M.
Mol. Immunol. 50:60-65(2012) · Mapped (3) |
| RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis. Loder S., Fakler M., Schoeneberger H., Cristofanon S., Leibacher J., Vanlangenakker N., Bertrand M.J., Vandenabeele P., Jeremias I., Debatin K.M. et al.
Leukemia 26:1020-1029(2012) · Mapped (2) |
| Identification of a novel pro-apoptotic role of NF-kappaB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells. Jennewein C., Karl S., Baumann B., Micheau O., Debatin K.M., Fulda S.
Oncogene 31:1468-1474(2012) · Mapped (1) |
| Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis. Unterkircher T., Cristofanon S., Vellanki S.H., Nonnenmacher L., Karpel-Massler G., Wirtz C.R., Debatin K.M., Fulda S.
Clin. Cancer Res. 17:4019-4030(2011) |
| Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway. Naumann I., Kappler R., von Schweinitz D., Debatin K.M., Fulda S.
Clin. Cancer Res. 17:3204-3218(2011) |
| cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Vanlangenakker N., Vanden Berghe T., Bogaert P., Laukens B., Zobel K., Deshayes K., Vucic D., Fulda S., Vandenabeele P., Bertrand M.J.
Cell Death Differ. 18:656-665(2011) · Mapped (23) |
| Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells. Haag C., Stadel D., Zhou S., Bachem M.G., Moller P., Debatin K.M., Fulda S.
Gut 60:225-237(2011) · Mapped (5) |
| Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Fischer-Posovszky P., Kukulus V., Tews D., Unterkircher T., Debatin K.M., Fulda S., Wabitsch M.
Am. J. Clin. Nutr. 92:5-15(2010) · Mapped (6) |
| CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer. Ripka S., Neesse A., Riedel J., Bug E., Aigner A., Poulsom R., Fulda S., Neoptolemos J., Greenhalf W., Barth P. et al.
Gut 59:1101-1110(2010) · Mapped (5) |
| Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. Mader I., Wabitsch M., Debatin K.M., Fischer-Posovszky P., Fulda S.
FASEB J. 24:1997-2009(2010) |
| Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response. Karl S., Pritschow Y., Volcic M., Hacker S., Baumann B., Wiesmuller L., Debatin K.M., Fulda S.
J. Cell. Mol. Med. 13:4239-4256(2009) · Mapped (1) |
| Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8. Hacker S., Dittrich A., Mohr A., Schweitzer T., Rutkowski S., Krauss J., Debatin K.M., Fulda S.
Oncogene 28:3097-3110(2009) · Mapped (12) |
| Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo. Vogler M., Walczak H., Stadel D., Haas T.L., Genze F., Jovanovic M., Gschwend J.E., Simmet T., Debatin K.M., Fulda S.
Cancer Res. 68:7956-7965(2008) · Mapped (2) |
| Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo. Kasperczyk H., Baumann B., Debatin K.M., Fulda S.
FASEB J. 23:21-33(2009) · Mapped (4) |
| Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Winkelmann J., Schormair B., Lichtner P., Ripke S., Xiong L., Jalilzadeh S., Fulda S., Putz B., Eckstein G., Hauk S. et al.
Nat. Genet. 39:1000-1006(2007) · Mapped (15) |
| Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation. Azoitei N., Brey A., Busch T., Fulda S., Adler G., Seufferlein T.
Oncogene 26:6536-6545(2007) · Mapped (8) |
| DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells. Ji P., Baumer N., Yin T., Diederichs S., Zhang F., Beger C., Welte K., Fulda S., Berdel W.E., Serve H. et al.
Int. J. Cancer 121:706-713(2007) · Mapped (21) |
| A membrane-bound FtsH protease is involved in osmoregulation in Synechocystis sp. PCC 6803: the compatible solute synthesizing enzyme GgpS is one of the targets for proteolysis. Stirnberg M., Fulda S., Huckauf J., Hagemann M., Kramer R., Marin K.
Mol. Microbiol. 63:86-102(2007) · UniProtKB (3) |
| Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance. Kilic M., Kasperczyk H., Fulda S., Debatin K.M.
Oncogene 26:2027-2038(2007) · Mapped (9) |
| Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin. Corbacioglu S., Kilic M., Westhoff M.A., Reinhardt D., Fulda S., Debatin K.M.
Blood 108:3504-3513(2006) · Mapped (7) |
| 5-Aza-2'-deoxycytidine and IFN-gamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8. Fulda S., Debatin K.M.
Oncogene 25:5125-5133(2006) · Mapped (3) |
| Proteomic screening of salt-stress-induced changes in plasma membranes of Synechocystis sp. strain PCC 6803. Huang F., Fulda S., Hagemann M., Norling B.
Proteomics 6:910-920(2006) · UniProtKB (1) |
