| Reduced surface expression of TLR4 by a V254I point mutation accounts for the low lipopolysaccharide responder phenotype of BALB/c B cells. Tsukamoto H., Fukudome K., Takao S., Tsuneyoshi N., Ohta S., Nagai Y., Ihara H., Miyake K., Ikeda Y., Kimoto M.
J. Immunol. 190:195-204(2013) · Mapped (13) |
| Blocking endothelial protein C receptor (EPCR) accelerates thrombus development in vivo. Centelles M.N., Puy C., Lopez-Sagaseta J., Fukudome K., Montes R., Hermida J.
Thromb. Haemost. 103:1239-1244(2010) · Mapped (4) |
| Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. Tsukamoto H., Fukudome K., Takao S., Tsuneyoshi N., Kimoto M.
Int. Immunol. 22:271-280(2010) · Mapped (13) |
| Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomerization of TLR4 required for signal transduction. Tsuneyoshi N., Kohara J., Bahrun U., Saitoh S., Akashi S., Gauchat J.F., Kimoto M., Fukudome K.
Cell. Immunol. 244:57-64(2006) · Mapped (7) |
| Endothelial protein C receptor and protease-activated receptor-1 mediate induction of a wound-healing phenotype in human keratinocytes by activated protein C. Xue M., Campbell D., Sambrook P.N., Fukudome K., Jackson C.J.
J. Invest. Dermatol. 125:1279-1285(2005) · Mapped (8) |
| Comparison of lipopolysaccharide-binding functions of CD14 and MD-2. Koraha J., Tsuneyoshi N., Kimoto M., Gauchat J.F., Nakatake H., Fukudome K.
Clin. Diagn. Lab. Immunol. 12:1292-1297(2005) · Mapped (4) |
| Anti-inflammatory effect of activated protein C in gastric epithelial cells. Nakamura M., Gabazza E.C., Imoto I., Yano Y., Taguchi O., Horiki N., Fukudome K., Suzuki K., Adachi Y.
J. Thromb. Haemost. 3:2721-2729(2005) · Mapped (20) |
| Recombinant human activated protein C upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein C receptor and activation of protease-activated receptor-1. Brueckmann M., Horn S., Lang S., Fukudome K., Schulze Nahrup A., Hoffmann U., Kaden J.J., Borggrefe M., Haase K.K., Huhle G.
Thromb. Haemost. 93:743-750(2005) · Mapped (25) |
| Activated protein C induces the release of microparticle-associated endothelial protein C receptor. Perez-Casal M., Downey C., Fukudome K., Marx G., Toh C.H.
Blood 105:1515-1522(2005) · Mapped (20) |
| Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. Uchiba M., Okajima K., Oike Y., Ito Y., Fukudome K., Isobe H., Suda T.
Circ. Res. 95:34-41(2004) · Mapped (3) |
| Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death. Hurtado V., Montes R., Gris J.C., Bertolaccini M.L., Alonso A., Martinez-Gonzalez M.A., Khamashta M.A., Fukudome K., Lane D.A., Hermida J.
Blood 104:1369-1374(2004) · Mapped (1) |
| Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Domotor E., Benzakour O., Griffin J.H., Yule D., Fukudome K., Zlokovic B.V.
Blood 101:4797-4801(2003) · Mapped (8) |
| Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Cheng T., Liu D., Griffin J.H., Fernandez J.A., Castellino F., Rosen E.D., Fukudome K., Zlokovic B.V.
Nat. Med. 9:338-342(2003) · Mapped (52) |
| Characterization and regulation of the 5'-flanking region of the murine endothelial protein C receptor gene. Gu J.M., Fukudome K., Esmon C.T.
J. Biol. Chem. 275:12481-12488(2000) · UniProtKB (1) · Mapped (3) |
| MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. Shimazu R., Akashi S., Ogata H., Nagai Y., Fukudome K., Miyake K., Kimoto M.
J. Exp. Med. 189:1777-1782(1999) · UniProtKB (1) · Mapped (4) |
| A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin. Aso T., Haque D., Fukudome K., Brower C.S., Conaway J.W., Conaway R.C.
Gene 168:277-278(1996) · UniProtKB (1) |
| Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. Fukudome K., Esmon C.T.
J. Biol. Chem. 269:26486-26491(1994) · UniProtKB (1) |
| Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR. Fukudome K., Esmon C.T.
J. Biol. Chem. 270:5571-5577(1995) · UniProtKB (2) · Mapped (2) |
| Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily. Takagi S., Fujikawa K., Imai T., Fukuhara N., Fukudome K., Minegishi M., Tsuchiya S., Konno T., Hinuma Y., Yoshie O.
Int. J. Cancer 61:706-715(1995) · UniProtKB (1) |
| C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. Imai T., Fukudome K., Takagi S., Nagira M., Furuse M., Fukuhara N., Nishimura M., Hinuma Y., Yoshie O.
J. Immunol. 149:2879-2886(1992) · UniProtKB (1) |
