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In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.

Hoeflich K.P., O'Brien C., Boyd Z., Cavet G., Guerrero S., Jung K., Januario T., Savage H., Punnoose E., Truong T. et al.

Clin. Cancer Res. 15:4649-4664(2009) · Mapped (8)

MicroRNAs are essential for development and function of inner ear hair cells in vertebrates.

Friedman L.M., Dror A.A., Mor E., Tenne T., Toren G., Satoh T., Biesemeier D.J., Shomron N., Fekete D.M., Hornstein E. et al.

Proc. Natl. Acad. Sci. U.S.A. 106:7915-7920(2009) · Mapped (13)

Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.

Hoeflich K.P., Herter S., Tien J., Wong L., Berry L., Chan J., O'Brien C., Modrusan Z., Seshagiri S., Lackner M. et al.

Cancer Res. 69:3042-3051(2009) · Mapped (3)

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer .

Folkes A.J., Ahmadi K., Alderton W.K., Alix S., Baker S.J., Box G., Chuckowree I.S., Clarke P.A., Depledge P., Eccles S.A. et al.

J. Med. Chem. 51:5522-5532(2008) · Mapped (1)

Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial.

Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S., Diggins L.T., He J., Saucier M., Deziel E. et al.

Genome Biol. 7:R90.1-R90.14(2006) · UniProtKB (5,886)

Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development.

Gori F., Friedman L.G., Demay M.B.

Dev. Biol. 295:498-506(2006) · Mapped (19)

Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo.

Gori F., Friedman L., Demay M.B.

J Musculoskelet Neuronal Interact 5:338-339(2005) · Mapped (2)

Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene.

Edgar K.A., Belvin M., Parks A.L., Whittaker K., Mahoney M.B., Nicoll M., Park C.C., Winter C.G., Chen F., Lickteig K. et al.

Genetics 170:161-171(2005) · Mapped (3)

Effect of a computer-based decision aid on knowledge, perceptions, and intentions about genetic testing for breast cancer susceptibility: a randomized controlled trial.

Green M.J., Peterson S.K., Baker M.W., Harper G.R., Friedman L.C., Rubinstein W.S., Mauger D.T.

JAMA 292:442-452(2004) · Mapped (43)

Sleep/wake disruption in Alzheimer's disease: APOE status and longitudinal course.

Yesavage J.A., Friedman L., Kraemer H., Tinklenberg J.R., Salehi A., Noda A., Taylor J.L., O'Hara R., Murphy G.

J Geriatr Psychiatry Neurol 17:20-24(2004) · Mapped (6)

Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome.

Parks A.L., Cook K.R., Belvin M., Dompe N.A., Fawcett R., Huppert K., Tan L.R., Winter C.G., Bogart K.P., Deal J.E. et al.

Nat. Genet. 36:288-292(2004) · Mapped (1)

Sex differences in GABA(A)ergic system in rat substantia nigra pars reticulata.

Ravizza T., Friedman L.K., Moshe S.L., Veliskova J.

Int. J. Dev. Neurosci. 21:245-254(2003) · Mapped (1)

Neurokinin-1 receptors are decreased in major depressive disorder.

Stockmeier C.A., Shi X., Konick L., Overholser J.C., Jurjus G., Meltzer H.Y., Friedman L., Blier P., Rajkowska G.

Neuroreport 13:1223-1227(2002) · Mapped (4)

gon-4, a cell lineage regulator required for gonadogenesis in Caenorhabditis elegans.

Friedman L., Santa Anna-Arriola S., Hodgkin J., Kimble J.

Dev. Biol. 228:350-362(2000) · Mapped (9)

Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans.

Friedman L., Higgin J.J., Moulder G., Barstead R., Raines R.T., Kimble J.

Proc. Natl. Acad. Sci. U.S.A. 97:4736-4741(2000) · UniProtKB (1) · Mapped (1)

Drosophila p53 is a structural and functional homolog of the tumor suppressor p53.

Ollmann M., Young L.M., Di Como C.J., Karim F., Belvin M., Robertson S., Whittaker K., Demsky M., Fisher W.W., Buchman A. et al.

Cell 101:91-101(2000) · UniProtKB (1) · Mapped (5)

Identification of Bordetella pertussis virulence-associated outer membrane proteins.

Passerini de Rossi B.N., Friedman L.E., Gonzalez Flecha F.L., Castello P.R., Franco M.A., Rossi J.P.F.C.

FEMS Microbiol. Lett. 172:9-13(1999) · UniProtKB (1)

Involvement of Brca2 in DNA repair.

Patel K.J., Yu V.P., Lee H., Corcoran A., Thistlethwaite F.C., Evans M.J., Colledge W.H., Friedman L.S., Ponder B.A., Venkitaraman A.R.

Mol. Cell 1:347-357(1998) · Mapped (4)

Thymic lymphomas in mice with a truncating mutation in Brca2.

Friedman L.S., Thistlethwaite F.C., Patel K.J., Yu V.P., Lee H., Venkitaraman A.R., Abel K.J., Carlton M.B., Hunter S.M., Colledge W.H. et al.

Cancer Res. 58:1338-1343(1998) · Mapped (4)

A low proportion of BRCA2 mutations in Finnish breast cancer families.

Vehmanen P., Friedman L.S., Eerola H., Sarantaus L., Pyrhoenen S., Ponder B.A.J., Muhonen T., Nevanlinna H.

Am. J. Hum. Genet. 60:1050-1058(1997) · UniProtKB (1)

Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1.

Abel K.J., Brody L.C., Valdes J.M., Erdos M.R., McKinley D.R., Castilla L.H., Merajver S.D., Couch F.J., Friedman L.S., Ostermeyer E.A. et al.

Genomics 37:161-171(1996) · UniProtKB (1) · Mapped (7)

Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.

Hu Y., Bloomquist B.T., Cornfield L.J., Decarr L.B., Flores-Riveros J.R., Friedman L., Jiang P., Lewis-Higgins L., Sadlowski Y., Schaefer J. et al.

J. Biol. Chem. 271:26315-26319(1996) · UniProtKB (2) · Mapped (1)

lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H).

Christensen S., Kodoyianni V., Bosenberg M., Friedman L., Kimble J.

Development 122:1373-1383(1996) · UniProtKB (1) · Mapped (5)

Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families.

Friedman L.S., Szabo C.I., Ostermeyer E.A., Dowd P., Butler L., Park T., Lee M.K., Goode E.L., Rowell S.E., King M.C.

Am. J. Hum. Genet. 57:1284-1297(1995) · UniProtKB (1)

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families.

Friedman L.S., Ostermeyer E.A., Szabo C.I., Dowd P., Lynch E.D., Rowell S.E., King M.-C.

Nat. Genet. 8:399-404(1994) · UniProtKB (1)

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