1 - 25 of 48 results for author:"Friedman L." in Literature citations
Results Customize
› Repeat search in UniProtKB (5,902)
| The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration. Cook D.R., Solski P.A., Bultman S.J., Kauselmann G., Schoor M., Kuehn R., Friedman L.S., Cowley D.O., Van Dyke T., Yeh J.J. et al. Genes Cancer 2:932-942(2011) · Mapped (8) |
| Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of alpha-synuclein and LRRK2 in the brain. Friedman L.G., Lachenmayer M.L., Wang J., He L., Poulose S.M., Komatsu M., Holstein G.R., Yue Z. J. Neurosci. 32:7585-7593(2012) · Mapped (11) |
| An ATP-site on-off switch that restricts phosphatase accessibility of Akt. Lin K., Lin J., Wu W.I., Ballard J., Lee B.B., Gloor S.L., Vigers G.P., Morales T.H., Friedman L.S., Skelton N. et al. Sci Signal 5:ra37-ra37(2012) · Mapped (2) |
| Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. Sutherlin D.P., Bao L., Berry M., Castanedo G., Chuckowree I., Dotson J., Folks A., Friedman L., Goldsmith R., Gunzner J. et al. J. Med. Chem. 54:7579-7587(2011) · Mapped (1) |
| Lack of Association Between COMT Polymorphisms and Apathy in Alzheimer's Disease. David R., Friedman L., Mulin E., Noda A., Le Duff F., Kennedy Q., Garcia R., Robert P.H., Yesavage J.A., Zeitzer J.M. J. Alzheimers Dis. 27:155-161(2011) · Mapped (7) |
| p21-activated kinase 1: PAK'ed with potential. Ong C.C., Jubb A.M., Zhou W., Haverty P.M., Harris A.L., Belvin M., Friedman L.S., Koeppen H., Hoeflich K.P. Oncotarget 2:491-496(2011) · Mapped (5) |
| Ordered and dynamic assembly of single spliceosomes. Hoskins A.A., Friedman L.J., Gallagher S.S., Crawford D.J., Anderson E.G., Wombacher R., Ramirez N., Cornish V.W., Gelles J., Moore M.J. Science 331:1289-1295(2011) · Mapped (8) |
| Faster REM sleep EEG and worse restedness in older insomniacs with HLA DQB1*0602. Zeitzer J.M., Fisicaro R.A., Grove M.E., Mignot E., Yesavage J.A., Friedman L. Psychiatry Res 187:397-400(2011) · Mapped (308) |
| Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy. Pfleger C.M., Wang J., Friedman L., Vittorino R., Conley L.M., Ho L., Fivecoat H.C., Pasinetti G.M. Int J Alzheimers Dis 2010:0-0(2010) · Mapped (1) |
| Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase. Staben S.T., Heffron T.P., Sutherlin D.P., Bhat S.R., Castanedo G.M., Chuckowree I.S., Dotson J., Folkes A.J., Friedman L.S., Lee L. et al. Bioorg. Med. Chem. Lett. 20:6048-6051(2010) · Mapped (1) |
| RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Hatzivassiliou G., Song K., Yen I., Brandhuber B.J., Anderson D.J., Alvarado R., Ludlam M.J., Stokoe D., Gloor S.L., Vigers G. et al. Nature 464:431-435(2010) · Mapped (1) |
| Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors. Edgar K.A., Wallin J.J., Berry M., Lee L.B., Prior W.W., Sampath D., Friedman L.S., Belvin M. Cancer Res. 70:1164-1172(2010) · Mapped (22) |
| A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. Lin L., Hutzen B., Li P.K., Ball S., Zuo M., DeAngelis S., Foust E., Sobo M., Friedman L., Bhasin D. et al. Neoplasia 12:39-50(2010) · Mapped (35) |
| Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. Sutherlin D.P., Sampath D., Berry M., Castanedo G., Chang Z., Chuckowree I., Dotson J., Folkes A., Friedman L., Goldsmith R. et al. J. Med. Chem. 53:1086-1097(2010) · Mapped (1) |
| Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicity. Friedman L.K., Segal M. Int. J. Dev. Neurosci. 28:195-205(2010) · Mapped (2) |
| Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Sos M.L., Fischer S., Ullrich R., Peifer M., Heuckmann J.M., Koker M., Heynck S., Stuckrath I., Weiss J., Fischer F. et al. Proc. Natl. Acad. Sci. U.S.A. 106:18351-18356(2009) · Mapped (19) |
| Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas. Hutzen B., Friedman L., Sobo M., Lin L., Cen L., De Angelis S., Yamakoshi H., Shibata H., Iwabuchi Y., Lin J. Int. J. Oncol. 35:867-872(2009) · Mapped (7) |
| In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models. Hoeflich K.P., O'Brien C., Boyd Z., Cavet G., Guerrero S., Jung K., Januario T., Savage H., Punnoose E., Truong T. et al. Clin. Cancer Res. 15:4649-4664(2009) · Mapped (9) |
| MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Friedman L.M., Dror A.A., Mor E., Tenne T., Toren G., Satoh T., Biesemeier D.J., Shomron N., Fekete D.M., Hornstein E. et al. Proc. Natl. Acad. Sci. U.S.A. 106:7915-7920(2009) · Mapped (19) |
| Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression. Hoeflich K.P., Herter S., Tien J., Wong L., Berry L., Chan J., O'Brien C., Modrusan Z., Seshagiri S., Lackner M. et al. Cancer Res. 69:3042-3051(2009) · Mapped (3) |
| The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer . Folkes A.J., Ahmadi K., Alderton W.K., Alix S., Baker S.J., Box G., Chuckowree I.S., Clarke P.A., Depledge P., Eccles S.A. et al. J. Med. Chem. 51:5522-5532(2008) · Mapped (1) |
| Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Ray S., Britschgi M., Herbert C., Takeda-Uchimura Y., Boxer A., Blennow K., Friedman L.F., Galasko D.R., Jutel M., Karydas A. et al. Nat. Med. 13:1359-1362(2007) · Mapped (3) |
| Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S., Diggins L.T., He J., Saucier M., Deziel E. et al. Genome Biol. 7:R90.1-R90.14(2006) · UniProtKB (5,886) |
| Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development. Gori F., Friedman L.G., Demay M.B. Dev. Biol. 295:498-506(2006) · Mapped (31) |
| Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo. Gori F., Friedman L., Demay M.B. J Musculoskelet Neuronal Interact 5:338-339(2005) · Mapped (2) |