| The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). Fluhrer R., Martin L., Klier B., Haug-Kroper M., Grammer G., Nuscher B., Haass C.
J. Biol. Chem. 287:5156-5163(2012) · UniProtKB (2) · Mapped (4) |
| The Nicastrin ectodomain adopts a highly thermostable structure. Fluhrer R., Kamp F., Grammer G., Nuscher B., Steiner H., Beyer K., Haass C.
Biol. Chem. 392:995-1001(2011) · Mapped (9) |
| Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis. Fukumori A., Fluhrer R., Steiner H., Haass C.
J. Neurosci. 30:7853-7862(2010) · Mapped (1) |
| Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. Martin L., Fluhrer R., Haass C.
J. Biol. Chem. 284:5662-5670(2009) · UniProtKB (4) |
| Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. Fluhrer R., Fukumori A., Martin L., Grammer G., Haug-Kroper M., Klier B., Winkler E., Kremmer E., Condron M.M., Teplow D.B. et al.
J. Biol. Chem. 283:30121-30128(2008) · Mapped (1) |
| Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. Martin L., Fluhrer R., Reiss K., Kremmer E., Saftig P., Haass C.
J. Biol. Chem. 283:1644-1652(2008) · UniProtKB (3) · Mapped (7) |
| A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Fluhrer R., Grammer G., Israel L., Condron M.M., Haffner C., Friedmann E., Bohland C., Imhof A., Martoglio B., Teplow D.B. et al.
Nat. Cell Biol. 8:894-896(2006) · UniProtKB (3) |
| Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. Krawitz P., Haffner C., Fluhrer R., Steiner H., Schmid B., Haass C.
J. Biol. Chem. 280:39515-39523(2005) · UniProtKB (5) · Mapped (10) |
| Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. Fluhrer R., Friedlein A., Haass C., Walter J.
J. Biol. Chem. 279:1585-1593(2004) · UniProtKB (1) |
| Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation. Fluhrer R., Multhaup G., Schlicksupp A., Okochi M., Takeda M., Lammich S., Willem M., Westmeyer G., Bode W., Walter J. et al.
J. Biol. Chem. 278:5531-5538(2003) · Mapped (11) |
