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Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.

Yu W., Chai H., Li Y., Zhao H., Xie X., Zheng H., Wang C., Wang X., Yang G., Cai X. et al.

Toxicol. Appl. Pharmacol. 264:73-83(2012) · Mapped (1)

Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.

Wang H., Falck J.R., Hall T.M., Shears S.B.

Nat. Chem. Biol. 8:111-116(2012) · UniProtKB (1) · Mapped (1)

Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides.

Gao N., Shang J., Huynh D., Manthati V.L., Arias C., Harding H.P., Kaufman R.J., Mohr I., Ron D., Falck J.R. et al.

Mol. Biol. Cell 22:2994-3009(2011) · Mapped (3)

Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries.

Gauthier K.M., Goldman D.H., Aggarwal N.T., Chawengsub Y., Falck J.R., Campbell W.B.

Am. J. Physiol. Heart Circ. Physiol. 300:H725-35(2011) · Mapped (3)

Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.

Nayeem M.A., Zeldin D.C., Boegehold M.A., Falck J.R.

Mol. Cell. Biochem. 350:101-111(2011) · Mapped (8)

Cytochrome P450 omega-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer.

Yu W., Chen L., Yang Y.Q., Falck J.R., Guo A.M., Li Y., Yang J.

Cancer Chemother. Pharmacol. 68:619-629(2011) · Mapped (7)

Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice.

Deng Y., Edin M.L., Theken K.N., Schuck R.N., Flake G.P., Kannon M.A., DeGraff L.M., Lih F.B., Foley J., Bradbury J.A. et al.

FASEB J. 25:703-713(2011) · Mapped (8)

High potassium intake enhances the inhibitory effect of 11,12-EET on ENaC.

Sun P., Lin D.H., Yue P., Jiang H., Gotlinger K.H., Schwartzman M.L., Falck J.R., Goli M., Wang W.H.

J. Am. Soc. Nephrol. 21:1667-1677(2010) · Mapped (2)

Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.

Nayeem M.A., Zeldin D.C., Boegehold M.A., Morisseau C., Marowsky A., Ponnoth D.S., Roush K.P., Falck J.R.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 299:R325-33(2010) · Mapped (11)

Inhibition of the adenosine2A receptor-epoxyeicosatrienoic acid pathway renders Dahl salt-resistant rats hypertensive.

Liclican E.L., Doumad A.B., Wang J., Li J., Falck J.R., Stier C.T. Jr., Carroll M.A.

Hypertension 54:1284-1290(2009) · Mapped (1)

20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.

Akbulut T., Regner K.R., Roman R.J., Avner E.D., Falck J.R., Park F.

Am. J. Physiol. Renal Physiol. 297:F662-70(2009) · Mapped (1)

Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism.

Marowsky A., Burgener J., Falck J.R., Fritschy J.M., Arand M.

Neuroscience 163:646-661(2009) · Mapped (9)

Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function.

Chaudhary K.R., Batchu S.N., Das D., Suresh M.R., Falck J.R., Graves J.P., Zeldin D.C., Seubert J.M.

Cardiovasc. Res. 83:362-370(2009) · Mapped (4)

Heme oxygenase-derived carbon monoxide restores vascular function in type 1 diabetes.

Rodella L.F., Vanella L., Peterson S.J., Drummond G., Rezzani R., Falck J.R., Abraham N.G.

Drug Metab Lett 2:290-300(2008) · Mapped (2)

Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells.

Katragadda D., Batchu S.N., Cho W.J., Chaudhary K.R., Falck J.R., Seubert J.M.

J. Mol. Cell. Cardiol. 46:867-875(2009) · Mapped (3)

Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD.

Park F., Sweeney W.E. Jr., Jia G., Akbulut T., Mueller B., Falck J.R., Birudaraju S., Roman R.J., Avner E.D.

Am. J. Physiol. Renal Physiol. 296:F575-82(2009) · Mapped (12)

Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.

Lin H., Fridy P.C., Ribeiro A.A., Choi J.H., Barma D.K., Vogel G., Falck J.R., Shears S.B., York J.D., Mayr G.W.

J. Biol. Chem. 284:1863-1872(2009) · UniProtKB (1) · Mapped (1)

Failure to upregulate the adenosine2A receptor-epoxyeicosatrienoic acid pathway contributes to the development of hypertension in Dahl salt-sensitive rats.

Liclican E.L., McGiff J.C., Falck J.R., Carroll M.A.

Am. J. Physiol. Renal Physiol. 295:F1696-704(2008) · Mapped (1)

Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice.

Nayeem M.A., Poloyac S.M., Falck J.R., Zeldin D.C., Ledent C., Ponnoth D.S., Ansari H.R., Mustafa S.J.

Am. J. Physiol. Heart Circ. Physiol. 295:H2068-78(2008) · Mapped (5)

Role of EDHF in type 2 diabetes-induced endothelial dysfunction.

Park Y., Capobianco S., Gao X., Falck J.R., Dellsperger K.C., Zhang C.

Am. J. Physiol. Heart Circ. Physiol. 295:H1982-8(2008) · Mapped (6)

Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response.

Keseru B., Barbosa-Sicard E., Popp R., Fisslthaler B., Dietrich A., Gudermann T., Hammock B.D., Falck J.R., Weissmann N., Busse R. et al.

FASEB J. 22:4306-4315(2008) · Mapped (6)

Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex.

Liu X., Li C., Falck J.R., Roman R.J., Harder D.R., Koehler R.C.

Am. J. Physiol. Heart Circ. Physiol. 295:H619-31(2008) · Mapped (2)

Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue.

Kostiuk M.A., Corvi M.M., Keller B.O., Plummer G., Prescher J.A., Hangauer M.J., Bertozzi C.R., Rajaiah G., Falck J.R., Berthiaume L.G.

FASEB J. 22:721-732(2008) · Mapped (3)

20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells.

Ishizuka T., Cheng J., Singh H., Vitto M.D., Manthati V.L., Falck J.R., Laniado-Schwartzman M.

J. Pharmacol. Exp. Ther. 324:103-110(2008) · Mapped (1)

Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress.

Choi J.H., Williams J., Cho J., Falck J.R., Shears S.B.

J. Biol. Chem. 282:30763-30775(2007) · UniProtKB (3) · Mapped (1)

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