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Effect of zinc supplementation on N-nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains.

Sun J., Liu J., Pan X., Quimby D., Zanesi N., Druck T., Pfeifer G.P., Croce C.M., Fong L.Y., Huebner K.

Carcinogenesis 32:351-358(2011) · Mapped (14)

Nit1 and Fhit tumor suppressor activities are additive.

Sun J., Okumura H., Yearsley M., Frankel W., Fong L.Y., Druck T., Huebner K.

J. Cell. Biochem. 107:1097-1106(2009) · UniProtKB (1) · Mapped (8)

Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.

Pichiorri F., Okumura H., Nakamura T., Garrison P.N., Gasparini P., Suh S.S., Druck T., McCorkell K.A., Barnes L.D., Croce C.M. et al.

J. Biol. Chem. 284:1040-1049(2009) · Mapped (9)

Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes.

Ishii H., Mimori K., Ishikawa K., Okumura H., Pichiorri F., Druck T., Inoue H., Vecchione A., Saito T., Mori M. et al.

Cancer Res. 68:3662-3670(2008) · Mapped (5)

Influence of a nonfragile FHIT transgene on murine tumor susceptibility.

McCorkell K.A., Mancini R., Siprashvili Z., Barnoski B.L., Iliopoulos D., Siracusa L.D., Zanesi N., Croce C.M., Fong L.Y., Druck T. et al.

Cytogenet. Genome Res. 118:196-203(2007) · Mapped (5)

Wwox suppresses prostate cancer cell growth through modulation of ErbB2-mediated androgen receptor signaling.

Qin H.R., Iliopoulos D., Nakamura T., Costinean S., Volinia S., Druck T., Sun J., Okumura H., Huebner K.

Mol. Cancer Res. 5:957-965(2007) · Mapped (19)

Fhit modulates the DNA damage checkpoint response.

Ishii H., Mimori K., Inoue H., Inageta T., Ishikawa K., Semba S., Druck T., Trapasso F., Tani K., Vecchione A. et al.

Cancer Res. 66:11287-11292(2006) · Mapped (5)

Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor.

Semba S., Han S.-Y., Qin H.R., McCorkell K.A., Iliopoulos D., Pekarsky Y., Druck T., Trapasso F., Croce C.M., Huebner K.

J. Biol. Chem. 281:28244-28253(2006) · UniProtKB (1) · Mapped (25)

Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential.

Semba S., Trapasso F., Fabbri M., McCorkell K.A., Volinia S., Druck T., Iliopoulos D., Pekarsky Y., Ishii H., Garrison P.N. et al.

Oncogene 25:2860-2872(2006) · UniProtKB (1)

Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer.

Iliopoulos D., Guler G., Han S.Y., Johnston D., Druck T., McCorkell K.A., Palazzo J., McCue P.A., Baffa R., Huebner K.

Oncogene 24:1625-1633(2005) · Mapped (9)

Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.

Aqeilan R.I., Pekarsky Y., Herrero J.J., Palamarchuk A., Letofsky J., Druck T., Trapasso F., Han S.-Y., Melino G., Huebner K. et al.

Proc. Natl. Acad. Sci. U.S.A. 101:4401-4406(2004) · UniProtKB (2) · Mapped (3)

The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation.

Druck T., Podolski J., Byrski T., Wyrwicz L., Zajaczek S., Kata G., Borowka A., Lubinski J., Huebner K.

J. Hum. Genet. 46:583-589(2001) · UniProtKB (1)

The tumor spectrum in FHIT-deficient mice.

Zanesi N., Fidanza V., Fong L.Y., Mancini R., Druck T., Valtieri M., Rudiger T., McCue P.A., Croce C.M., Huebner K.

Proc. Natl. Acad. Sci. U.S.A. 98:10250-10255(2001) · UniProtKB (1) · Mapped (5)

Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit.

Shiraishi T., Druck T., Mimori K., Flomenberg J., Berk L., Alder H., Miller W., Huebner K., Croce C.M.

Proc. Natl. Acad. Sci. U.S.A. 98:5722-5727(2001) · UniProtKB (1) · Mapped (5)

Muir-Torre-like syndrome in Fhit-deficient mice.

Fong L.Y., Fidanza V., Zanesi N., Lock L.F., Siracusa L.D., Mancini R., Siprashvili Z., Ottey M., Martin S.E., Druck T. et al.

Proc. Natl. Acad. Sci. U.S.A. 97:4742-4747(2000) · UniProtKB (1) · Mapped (5)

The murine Fhit locus: isolation, characterization, and expression in normal and tumor cells.

Pekarsky Y., Druck T., Cotticelli M.G., Ohta M., Shou J., Mendrola J., Montgomery J.C., Buchberg A.M., Siracusa L.D., Manenti G. et al.

Cancer Res. 58:3401-3408(1998) · UniProtKB (1) · Mapped (14)

Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans.

Pekarsky Y., Campiglio M., Siprashvili Z., Druck T., Sedkov Y., Tillib S., Draganescu A., Wermuth P., Rothman J.H., Huebner K. et al.

Proc. Natl. Acad. Sci. U.S.A. 95:8744-8749(1998) · UniProtKB (5) · Mapped (6)

Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.

Inoue H., Ishii H., Alder H., Snyder E., Druck T., Huebner K., Croce C.M.

Proc. Natl. Acad. Sci. U.S.A. 94:14584-14589(1997) · UniProtKB (1)

Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.

Prasad R., Zhadanov A.B., Sedkov Y., Bullrich F., Druck T., Rallapalli R., Yano T., Alder H., Croce C.M., Huebner K. et al.

Oncogene 15:549-560(1997) · UniProtKB (1)

Identification of a conserved family of Meis1-related homeobox genes.

Steelman S., Moskow J.J., Muzynski K., North C., Druck T., Montgomery J.C., Huebner K., Daar I.O., Buchberg A.M.

Genome Res. 7:142-156(1997) · UniProtKB (5) · Mapped (21)

Structure and expression of the human FHIT gene in normal and tumor cells.

Druck T., Hadaczek P., Fu T.B., Ohta M., Siprashvili Z., Baffa R., Negrini M., Kastury K., Veronese M.L., Rosen D. et al.

Cancer Res. 57:504-512(1997) · UniProtKB (1)

Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation.

Kastury K., Ohta M., Lasota J., Moir D., Dorman T., Laforgia S., Druck T., Huebner K.

Genomics 32:225-235(1996) · UniProtKB (1)

Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12.

Takayama S., Kochel K., Irie S., Inazawa J., Abe T., Sato T., Druck T., Huebner K., Reed J.C.

Genomics 35:494-498(1996) · UniProtKB (1) · Mapped (3)

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.

Ohta M., Inoue H., Cotticelli M.G., Kastury K., Baffa R., Palazzo J., Siprashvili Z., Mori M., McCue P., Druck T. et al.

Cell 84:587-597(1996) · UniProtKB (2) · Mapped (5)

Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP.

Druck T., Gu Y., Prabhala G., Cannizzaro L.A., Park S.H., Huebner K., Keen J.H.

Genomics 30:94-97(1995)

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