| The N-terminal extension is essential for the formation of the active dimeric structure of liver peroxisomal alanine:glyoxylate aminotransferase. Montioli R., Fargue S., Lewin J., Zamparelli C., Danpure C.J., Borri Voltattorni C., Cellini B.
Int. J. Biochem. Cell Biol. 44:536-546(2012) · Mapped (8) |
| Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting. Djordjevic S., Zhang X., Bartlam M., Ye S., Rao Z., Danpure C.J.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66:233-236(2010) · Mapped (8) |
| Molecular etiology of primary hyperoxaluria type 1: new directions for treatment. Danpure C.J.
Am. J. Nephrol. 25:303-310(2005) · Mapped (8) |
| Peroxisomal import of human alanine:glyoxylate aminotransferase requires ancillary targeting information remote from its C terminus. Huber P.A., Birdsey G.M., Lumb M.J., Prowse D.T., Perkins T.J., Knight D.R., Danpure C.J.
J. Biol. Chem. 280:27111-27120(2005) · Mapped (8) |
| Diet and the frequency of the alanine:glyoxylate aminotransferase Pro11Leu polymorphism in different human populations. Caldwell E.F., Mayor L.R., Thomas M.G., Danpure C.J.
Hum. Genet. 115:504-509(2004) · Mapped (9) |
| Differential enzyme targeting as an evolutionary adaptation to herbivory in carnivora. Birdsey G.M., Lewin J., Cunningham A.A., Bruford M.W., Danpure C.J.
Mol. Biol. Evol. 21:632-646(2004) · UniProtKB (12) |
| Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1. Zhang X., Roe S.M., Hou Y., Bartlam M., Rao Z., Pearl L.H., Danpure C.J.
J. Mol. Biol. 331:643-652(2003) · UniProtKB (1) · Mapped (7) |
| Fungal hydrogenosomes contain mitochondrial heat-shock proteins. van der Giezen M., Birdsey G.M., Horner D.S., Lucocq J., Dyal P.L., Benchimol M., Danpure C.J., Embley T.M.
Mol. Biol. Evol. 20:1051-1061(2003) · UniProtKB (2) |
| Molecular basis for the dual mitochondrial and cytosolic localization of alanine:glyoxylate aminotransferase in amphibian liver cells. Holbrook J.D., Danpure C.J.
J. Biol. Chem. 277:2336-2344(2002) · UniProtKB (1) |
| The peroxisomal targeting sequence type 1 receptor, Pex5p, and the peroxisomal import efficiency of alanine:glyoxylate aminotransferase. Knott T.G., Birdsey G.M., Sinclair K.E., Gallagher I.M., Purdue P.E., Danpure C.J.
Biochem. J. 352:409-418(2000) · UniProtKB (1) · Mapped (1) |
| Functional synergism between the most common polymorphism in human alanine:glyoxylate aminotransferase and four of the most common disease-causing mutations. Lumb M.J., Danpure C.J.
J. Biol. Chem. 275:36415-36422(2000) · UniProtKB (1) |
| Molecular adaptation of alanine:glyoxylate aminotransferase targeting in primates. Holbrook J.D., Birdsey G.M., Yang Z., Bruford M.W., Danpure C.J.
Mol. Biol. Evol. 17:387-400(2000) · UniProtKB (11) |
| Evolution of alanine:glyoxylate aminotransferase intracellular targeting: structural and functional analysis of the guinea pig gene. Birdsey G.M., Danpure C.J.
Biochem. J. 331:49-60(1998) · UniProtKB (1) |
| Primary hyperoxaluria type 1 and peroxisome-to-mitochondrion mistargeting of alanine:glyoxylate aminotransferase. Danpure C.J.
Biochimie 75:309-315(1993) · UniProtKB (1) |
| Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting. Analysis of the feline gene. Lumb M.J., Purdue P.E., Danpure C.J.
Eur. J. Biochem. 221:53-62(1994) · UniProtKB (1) |
| Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation. Danpure C.J., Purdue P.E., Fryer P., Griffiths S., Allsop J., Lumb M.J., Guttridge K.M., Jennings P.R., Scheinman J.I., Mauer S.M. et al.
Am. J. Hum. Genet. 53:417-432(1993) · UniProtKB (1) · Mapped (2) |
| Evolution of alanine:glyoxylate aminotransferase 1 peroxisomal and mitochondrial targeting. A survey of its subcellular distribution in the livers of various representatives of the classes Mammalia, Aves and Amphibia. Danpure C.J., Fryer P., Jennings P.R., Allsop J., Griffiths S., Cunningham A.
Eur. J. Cell Biol. 64:295-313(1994) · Mapped (3) |
| Mammalian alanine/glyoxylate aminotransferase 1 is imported into peroxisomes via the PTS1 translocation pathway. Increased degeneracy and context specificity of the mammalian PTS1 motif and implications for the peroxisome-to-mitochondrion mistargeting of AGT in primary hyperoxaluria type 1. Motley A., Lumb M.J., Oatey P.B., Jennings P.R., de Zoysa P.A., Wanders R.J.A., Tabak H.F., Danpure C.J.
J. Cell Biol. 131:95-109(1995) · UniProtKB (1) |
| Immunocytochemical localization of human hepatic alanine: glyoxylate aminotransferase in control subjects and patients with primary hyperoxaluria type 1. Cooper P.J., Danpure C.J., Wise P.J., Guttridge K.M.
J. Histochem. Cytochem. 36:1285-1294(1988) |
| Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon. Takada Y., Kaneko N., Esumi H., Purdue P.E., Danpure C.J.
Biochem. J. 268:517-520(1990) · UniProtKB (1) |
| Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase. Purdue P.E., Lumb M.J., Fox M., Griffo G., Hamon-Benais C., Povey S., Danpure C.J.
Genomics 10:34-42(1991) · UniProtKB (1) |
| Mistargeting of peroxisomal L-alanine:glyoxylate aminotransferase to mitochondria in primary hyperoxaluria patients depends upon activation of a cryptic mitochondrial targeting sequence by a point mutation. Purdue P.E., Allsop J., Isaya G., Rosenberg L.E., Danpure C.J.
Proc. Natl. Acad. Sci. U.S.A. 88:10900-10904(1991) · UniProtKB (1) |
| Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1. Purdue P.E., Takada Y., Danpure C.J.
J. Cell Biol. 111:2341-2351(1990) · UniProtKB (1) |
| A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1. Purdue P.E., Lumb M.J., Allsop J., Minatogawa Y., Danpure C.J.
Genomics 13:215-218(1992) · UniProtKB (2) |
| Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting. Analysis of the marmoset and rabbit genes. Purdue P.E., Lumb M.J., Danpure C.J.
Eur. J. Biochem. 207:757-766(1992) · UniProtKB (2) |
