19 results for author:"Copeland R.A." in Literature citations
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| Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. Basavapathruni A., Jin L., Daigle S.R., Majer C.R., Therkelsen C.A., Wigle T.J., Kuntz K.W., Chesworth R., Pollock R.M., Scott M.P. et al. Chem Biol Drug Des 80:971-980(2012) · Mapped (1) |
| A687V EZH2 is a gain-of-function mutation found in lymphoma patients. Majer C.R., Jin L., Scott M.P., Knutson S.K., Kuntz K.W., Keilhack H., Smith J.J., Moyer M.P., Richon V.M., Copeland R.A. et al. FEBS Lett. 586:3448-3451(2012) · Mapped (9) |
| Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors. Thompson L.A., Shi J., Decicco C.P., Tebben A.J., Olson R.E., Boy K.M., Guernon J.M., Good A.C., Liauw A., Zheng C. et al. Bioorg. Med. Chem. Lett. 21:6909-6915(2011) · Mapped (1) |
| The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states. Wigle T.J., Knutson S.K., Jin L., Kuntz K.W., Pollock R.M., Richon V.M., Copeland R.A., Scott M.P. FEBS Lett. 585:3011-3014(2011) · Mapped (9) |
| Chemogenetic analysis of human protein methyltransferases. Richon V.M., Johnston D., Sneeringer C.J., Jin L., Majer C.R., Elliston K., Jerva L.F., Scott M.P., Copeland R.A. Chem Biol Drug Des 78:199-210(2011) · Mapped (1) |
| Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites. Pappalardi M.B., McNulty D.E., Martin J.D., Fisher K.E., Jiang Y., Burns M.C., Zhao H., Ho T., Sweitzer S., Schwartz B. et al. Biochem. J. 436:363-369(2011) · UniProtKB (2) |
| Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site. Yang J., Campobasso N., Biju M.P., Fisher K., Pan X.Q., Cottom J., Galbraith S., Ho T., Zhang H., Hong X. et al. Chem. Biol. 18:177-186(2011) · Mapped (1) |
| Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Sneeringer C.J., Scott M.P., Kuntz K.W., Knutson S.K., Pollock R.M., Richon V.M., Copeland R.A. Proc. Natl. Acad. Sci. U.S.A. 107:20980-20985(2010) · Mapped (9) |
| Evidence for allosteric interactions of antagonist binding to the smoothened receptor. Rominger C.M., Bee W.L., Copeland R.A., Davenport E.A., Gilmartin A., Gontarek R., Hornberger K.R., Kallal L.A., Lai Z., Lawrie K. et al. J. Pharmacol. Exp. Ther. 329:995-1005(2009) · Mapped (4) |
| Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis. Pappalardi M.B., Martin J.D., Jiang Y., Burns M.C., Zhao H., Ho T., Sweitzer S., Lor L., Schwartz B., Duffy K. et al. Biochemistry 47:11165-11167(2008) · Mapped (3) |
| Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. Heerding D.A., Rhodes N., Leber J.D., Clark T.J., Keenan R.M., Lafrance L.V., Li M., Safonov I.G., Takata D.T., Venslavsky J.W. et al. J. Med. Chem. 51:5663-5679(2008) · UniProtKB (1) |
| The catalytic role of INCENP in Aurora B activation and the kinetic mechanism of Aurora B/INCENP. Yang J., Zappacosta F., Annan R.S., Nurse K., Tummino P.J., Copeland R.A., Lai Z. Biochem. J. 417:355-360(2009) · Mapped (3) |
| Binding of TPX2 to Aurora A alters substrate and inhibitor interactions. Anderson K., Yang J., Koretke K., Nurse K., Calamari A., Kirkpatrick R.B., Patrick D., Silva D., Tummino P.J., Copeland R.A. et al. Biochemistry 46:10287-10295(2007) · Mapped (14) |
| An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation. Rominger C.M., Schaber M.D., Yang J., Gontarek R.R., Weaver K.L., Broderick T., Carter L., Copeland R.A., May E.W. Arch. Biochem. Biophys. 464:130-137(2007) · Mapped (3) |
| SCF(beta-TRCP) and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4. Strack P., Caligiuri M., Pelletier M., Boisclair M., Theodoras A., Beer-Romero P., Glass S., Parsons T., Copeland R.A., Auger K.R. et al. Oncogene 19:3529-3536(2000) · UniProtKB (2) |
| Dihydroorotate dehydrogenase B of Enterococcus faecalis. Characterization and insights into chemical mechanism. Marcinkeviciene J., Tinney L.M., Wang K.H., Rogers M.J., Copeland R.A. Biochemistry 38:13129-13137(1999) · UniProtKB (2) |
| Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. Abbaszade I., Liu R.-Q., Yang F., Rosenfeld S.A., Ross O.H., Link J.R., Ellis D.M., Tortorella M.D., Pratta M.A., Hollis J.M. et al. J. Biol. Chem. 274:23443-23450(1999) · UniProtKB (1) · Mapped (2) |
| Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Tortorella M.D., Burn T.C., Pratta M.A., Abbaszade I., Hollis J.M., Liu R.-Q., Rosenfeld S.A., Copeland R.A., Decicco C.P., Wynn R. et al. |
| Recombinant human dihydroorotate dehydrogenase: expression, purification, and characterization of a catalytically functional truncated enzyme. Copeland R.A., Davis J.P., Dowling R.L., Lombardo D., Murphy K.B., Patterson T.A. Arch. Biochem. Biophys. 323:79-86(1995) · UniProtKB (1) |