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The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis.

Teckchandani A., Mulkearns E.E., Randolph T.W., Toida N., Cooper J.A.

Mol. Biol. Cell 23:2905-2916(2012) · UniProtKB (7) · Mapped (18)

Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein.

Kim T., Ravilious G.E., Sept D., Cooper J.A.

J. Biol. Chem. 287:15251-15262(2012) · Mapped (4)

Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice.

Matsuki T., Zaka M., Guerreiro R., van der Brug M.P., Cooper J.A., Cookson M.R., Hardy J.A., Howell B.W.

PLoS ONE 7:e31152-e31152(2012) · Mapped (3)

FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.

Mulkearns E.E., Cooper J.A.

Mol. Biol. Cell 23:1330-1342(2012) · UniProtKB (4) · Mapped (23)

Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning.

Stuchell-Brereton M.D., Siglin A., Li J., Moore J.K., Ahmed S., Williams J.C., Cooper J.A.

Mol. Biol. Cell 22:2690-2701(2011) · Mapped (4)

Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex.

Jossin Y., Cooper J.A.

Nat. Neurosci. 14:697-703(2011) · Mapped (15)

Differential transformation capacity of Src family kinases during the initiation of prostate cancer.

Cai H., Smith D.A., Memarzadeh S., Lowell C.A., Cooper J.A., Witte O.N.

Proc. Natl. Acad. Sci. U.S.A. 108:6579-6584(2011) · Mapped (12)

Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.

Talmud P.J., Cooper J.A., Gaunt T., Holmes M.V., Shah S., Palmen J., Drenos F., Shah T., Kumari M., Kivimaki M. et al.

Diabetologia 54:1710-1719(2011) · Mapped (1)

Association of a sequence variant in DAB2IP with coronary heart disease.

HIFMECH Consortium
Harrison S.C., Cooper J.A., Li K., Talmud P.J., Sofat R., Stephens J.W., Hamsten A., Sanders J., Montgomery H., Neil A. et al.

Eur. Heart J. 33:881-888(2012) · Mapped (3)

Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus.

Tang T.S., Prior S.L., Li K.W., Ireland H.A., Bain S.C., Hurel S.J., Cooper J.A., Humphries S.E., Stephens J.W.

Nutr Metab Cardiovasc Dis 22:417-425(2012) · Mapped (3)

Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment.

Matsuki T., Matthews R.T., Cooper J.A., van der Brug M.P., Cookson M.R., Hardy J.A., Olson E.C., Howell B.W.

Cell 143:826-836(2010) · Mapped (42)

The spindle position checkpoint is coordinated by the Elm1 kinase.

Moore J.K., Chudalayandi P., Heil-Chapdelaine R.A., Cooper J.A.

J. Cell Biol. 191:493-503(2010) · Mapped (5)

The interaction of capping protein with the barbed end of the actin filament.

Kim T., Cooper J.A., Sept D.

J. Mol. Biol. 404:794-802(2010) · Mapped (8)

Actin dynamics and endocytosis in yeast and mammals.

Galletta B.J., Mooren O.L., Cooper J.A.

Curr. Opin. Biotechnol. 21:604-610(2010) · Mapped (10)

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

Hannigan A., Smith P., Kalna G., Lo Nigro C., Orange C., O'Brien D.I., Shah R., Syed N., Spender L.C., Herrera B. et al.

J. Clin. Invest. 120:2842-2857(2010) · Mapped (12)

PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry.

Casas J.P., Ninio E., Panayiotou A., Palmen J., Cooper J.A., Ricketts S.L., Sofat R., Nicolaides A.N., Corsetti J.P., Fowkes F.G. et al.

Circulation 121:2284-2293(2010) · Mapped (4)

Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration.

Simo S., Jossin Y., Cooper J.A.

J. Neurosci. 30:5668-5676(2010) · Mapped (21)

Overlapping and distinct functions for cofilin, coronin and Aip1 in actin dynamics in vivo.

Lin M.C., Galletta B.J., Sept D., Cooper J.A.

J. Cell. Sci. 123:1329-1342(2010) · Mapped (4)

Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project.

Taylor A., Wang D., Patel K., Whittall R., Wood G., Farrer M., Neely R.D., Fairgrieve S., Nair D., Barbir M. et al.

Clin. Genet. 77:572-580(2010) · Mapped (22)

Genetic variation within IL18 is associated with insulin levels, insulin resistance and postprandial measures.

EARSII Consortium
Smart M.C., Dedoussis G., Yiannakouris N., Grisoni M.L., Dror G.K., Yannakoulia M., Papoutsakis C., Louizou E., Mantzoros C.S., Melistas L. et al.

Nutr Metab Cardiovasc Dis 21:476-484(2011) · Mapped (3)

Coordinating mitosis with cell polarity: Molecular motors at the cell cortex.

Moore J.K., Cooper J.A.

Semin. Cell Dev. Biol. 21:283-289(2010) · Mapped (10)

Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.

Talmud P.J., Hingorani A.D., Cooper J.A., Marmot M.G., Brunner E.J., Kumari M., Kivimaki M., Humphries S.E.

BMJ 340:b4838-b4838(2010) · Mapped (92)

Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms.

Caplin B., Nitsch D., Gill H., Hoefield R., Blackwell S., MacKenzie D., Cooper J.A., Middleton R.J., Talmud P.J., Veitch P. et al.

Kidney Int. 77:459-467(2010) · Mapped (6)

Distinct roles for the actin nucleators Arp2/3 and hDia1 during NK-mediated cytotoxicity.

Butler B., Cooper J.A.

Curr. Biol. 19:1886-1896(2009) · Mapped (21)

The spindle position checkpoint requires positional feedback from cytoplasmic microtubules.

Moore J.K., Magidson V., Khodjakov A., Cooper J.A.

Curr. Biol. 19:2026-2030(2009) · Mapped (1)

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