| Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia (dagger) dagger Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1). Verhoest P.R., Chapin D.S., Corman M., Fonseca K., Harms J.F., Hou X., Marr E.S., Menniti F.S., Nelson F., O'Connor R. et al.
J. Med. Chem. 0:0-0(2009) · Mapped (1) |
| Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase. Kiely P.A., Baillie G.S., Barrett R., Buckley D.A., Adams D.R., Houslay M.D., O'Connor R.
J. Biol. Chem. 284:20263-20274(2009) · Mapped (35) |
| Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett syndrome. O'Connor R.D., Zayzafoon M., Farach-Carson M.C., Schanen N.C.
Bone 45:346-356(2009) · Mapped (1) |
| A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. Perona-Wright G., Jenkins S.J., O'Connor R.A., Zienkiewicz D., McSorley H.J., Maizels R.M., Anderton S.M., MacDonald A.S.
J. Immunol. 182:2808-2815(2009) · Mapped (2) |
| Polymorphic mucin antigens CpMuc4 and CpMuc5 are integral to Cryptosporidium parvum infection in vitro. O'Connor R.M., Burns P.B., Ha-Ngoc T., Scarpato K., Khan W., Kang G., Ward H.
Eukaryotic Cell 8:461-469(2009) · UniProtKB (6) |
| (15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase. Yu T.Y., O'Connor R.D., Sivertsen A.C., Chiauzzi C., Poliks B., Fischer M., Bacher A., Haase I., Cushman M., Schaefer J.
Biochemistry 47:13942-13951(2008) · Mapped (1) |
| (15)N{(31)P} REDOR NMR Studies of the Binding of Phosphonate Reaction Intermediate Analogues to Saccharomyces cerevisiae Lumazine Synthase (dagger). Yu T.Y., O'Connor R.D., Sivertsen A.C., Chiauzzi C., Poliks B., Fischer M., Bacher A., Haase I., Cushman M., Schaefer J.
Biochemistry 0:0-0(2008) · Mapped (1) |
| Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB. Healy N.C., O'Connor R.
J. Leukoc. Biol. 85:481-490(2009) · Mapped (16) |
| The EphA3 receptor is expressed in a subset of rhabdomyosarcoma cell lines and suppresses cell adhesion and migration. Clifford N., Smith L.M., Powell J., Gattenlohner S., Marx A., O'Connor R.
J. Cell. Biochem. 105:1250-1259(2008) · Mapped (3) |
| Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. Macartney-Coxson D.P., Hood K.A., Shi H.J., Ward T., Wiles A., O'Connor R., Hall D.A., Lea R.A., Royds J.A., Stubbs R.S. et al.
BMC Cancer 8:187-187(2008) · Mapped (15) |
| Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration. Kiely P.A., Baillie G.S., Lynch M.J., Houslay M.D., O'Connor R.
J. Biol. Chem. 283:22952-22961(2008) · Mapped (16) |
| Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR. O'Donovan H.C., Kiely P.A., O'Connor R.
Cell. Signal. 19:2588-2595(2007) · Mapped (2) |
| Drug metabolism-related genes as potential biomarkers: analysis of expression in normal and tumour breast tissue. Martinez V., Kennedy S., Doolan P., Gammell P., Joyce H., Kenny E., Prakash Mehta J., Ryan E., O'Connor R., Crown J. et al.
Breast Cancer Res. Treat. 110:521-530(2008) · Mapped (7) |
| Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients. Pugh T.J., Bebb G., Barclay L., Sutcliffe M., Fee J., Salski C., O'Connor R., Ho C., Murray N., Melosky B. et al.
BMC Cancer 7:128-128(2007) · Mapped (23) |
| Molecular and serologic characterization, pathogenicity, and protection studies with infectious bronchitis virus field isolates from California. Jackwood M.W., Hilt D.A., Williams S.M., Woolcock P., Cardona C., O'Connor R.
Avian Dis. 51:527-533(2007) · UniProtKB (5) |
| The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth. Floyd S., Favre C., Lasorsa F.M., Leahy M., Trigiante G., Stroebel P., Marx A., Loughran G., O'Callaghan K., Marobbio C.M. et al.
Mol. Biol. Cell 18:3545-3555(2007) · Mapped (13) |
| Dopamine receptor genes (DRD2, DRD3 and DRD4) and gene-gene interactions associated with smoking-related behaviors. Vandenbergh D.J., O'Connor R.J., Grant M.D., Jefferson A.L., Vogler G.P., Strasser A.A., Kozlowski L.T.
Addict Biol 12:106-116(2007) · Mapped (69) |
| A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis. O'Connor R.S., Mills S.T., Jones K.A., Ho S.N., Pavlath G.K.
J. Cell. Sci. 120:149-159(2007) · Mapped (11) |
| Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. Ellson C.D., Davidson K., Ferguson G.J., O'Connor R., Stephens L.R., Hawkins P.T.
J. Exp. Med. 203:1927-1937(2006) · Mapped (4) |
| Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration. Kiely P.A., O'Gorman D., Luong K., Ron D., O'Connor R.
Mol. Cell. Biol. 26:4041-4051(2006) · Mapped (8) |
| Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-beta1-induced release of extracellular fibroblast growth factor-2 and phosphorylation of p38 MAPK and JNK. Khalil N., Xu Y.D., O'Connor R., Duronio V.
J. Biol. Chem. 280:43000-43009(2005) · Mapped (4) |
| Sca-1 negatively regulates proliferation and differentiation of muscle cells. Mitchell P.O., Mills T., O'Connor R.S., Kline E.R., Graubert T., Dzierzak E., Pavlath G.K.
Dev. Biol. 283:240-252(2005) · Mapped (1) |
| Infection-induced apoptosis deletes bystander CD4+ T cells: a mechanism for suppression of autoimmunity during BCG infection. O'Connor R.A., Wittmer S., Dalton D.K.
J. Autoimmun. 24:93-100(2005) · Mapped (11) |
| BOC, brother of CDO, is a dorsoventral axon-guidance molecule in the embryonic vertebrate brain. Connor R.M., Allen C.L., Devine C.A., Claxton C., Key B.
J. Comp. Neurol. 485:32-42(2005) · Mapped (2) |
| The DNA sequence of the human X chromosome. Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P. et al.
Nature 434:325-337(2005) · UniProtKB (1,199) |
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