| Combined QM/MM study of thyroid and steroid hormone analogue interactions with alphavbeta3 integrin. Freindorf M., Furlani T.R., Kong J., Cody V., Davis F.B., Davis P.J.
J. Biomed. Biotechnol. 2012:959057-959057(2012) · Mapped (4) |
| Structural analysis of Pneumocystis carinii dihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d]pyrimidine. Cody V., Pace J., Stewart E.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68:418-423(2012) · Mapped (1) |
| Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode. Cody V., Pace J., Nowak J.
Acta Crystallogr. D Biol. Crystallogr. 67:875-880(2011) · Mapped (1) |
| Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase. Cody V., Pace J., Piraino J., Queener S.F.
J. Struct. Biol. 176:52-59(2011) · Mapped (1) |
| Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. Zhang X., Zhou X., Kisliuk R.L., Piraino J., Cody V., Gangjee A.
Bioorg. Med. Chem. 19:3585-3594(2011) · Mapped (1) |
| Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-(omega-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives. Cody V., Pace J.
Acta Crystallogr. D Biol. Crystallogr. 67:1-7(2011) · Mapped (2) |
| Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase. Cody V., Piraino J., Pace J., Li W., Gangjee A.
Acta Crystallogr. D Biol. Crystallogr. 66:1271-1277(2010) · Mapped (1) |
| Chemically Self-Assembled Antibody Nanorings (CSANs): Design and Characterization of an Anti-CD3 IgM Biomimetic. Li Q., So C.R., Fegan A., Cody V., Sarikaya M., Vallera D.A., Wagner C.R.
J. Am. Chem. Soc. 0:0-0(2010) · Mapped (1) |
| Probing the impact of the echinT C-terminal domain on structure and catalysis. Bardaweel S., Pace J., Chou T.F., Cody V., Wagner C.R.
J. Mol. Biol. 404:627-638(2010) · UniProtKB (1) · Mapped (1) |
| Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Gangjee A., Li W., Lin L., Zeng Y., Ihnat M., Warnke L.A., Green D.W., Cody V., Pace J., Queener S.F.
Bioorg. Med. Chem. 17:7324-7336(2009) · UniProtKB (1) |
| Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. Gangjee A., Li W., Kisliuk R.L., Cody V., Pace J., Piraino J., Makin J.
J. Med. Chem. 52:4892-4902(2009) · UniProtKB (1) |
| The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex. Cody V., Pace J., Lin L., Gangjee A.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65:762-766(2009) · Mapped (1) |
| Sliding clamp-DNA interactions are required for viability and contribute to DNA polymerase management in Escherichia coli. Heltzel J.M., Scouten Ponticelli S.K., Sanders L.H., Duzen J.M., Cody V., Pace J., Snell E.H., Sutton M.D.
J. Mol. Biol. 387:74-91(2009) · Mapped (1) |
| Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes. Cody V., Pace J., Makin J., Piraino J., Queener S.F., Rosowsky A.
Biochemistry 48:1702-1711(2009) · UniProtKB (1) · Mapped (3) |
| Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine. Cody V., Pace J., Rosowsky A.
Acta Crystallogr. D 64:977-984(2008) · UniProtKB (1) |
| New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions. Cody V., Pace J., Chisum K., Rosowsky A.
Proteins 65:959-969(2006) · UniProtKB (2) · Mapped (1) |
| Ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-T4Ac complex at 2.2 Angstrom resolution. Neumann P., Cody V., Wojtczak A.
Acta Crystallogr. D Biol. Crystallogr. 61:1313-1319(2005) · Mapped (1) |
| Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Cody V., Luft J.R., Pangborn W.
Acta Crystallogr. D 61:147-155(2005) · UniProtKB (2) |
| Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate. Cody V., Galitsky N., Luft J.R., Pangborn W., Gangjee A., Devraj R., Queener S.F., Blakley R.L.
Acta Crystallogr. D Biol. Crystallogr. 53:638-649(1997) · Mapped (1) |
| Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution. Wojtczak A., Cody V., Luft J.R., Pangborn W.
Acta Crystallogr. D Biol. Crystallogr. 52:758-765(1996) · Mapped (1) |
| Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Cody V., Luft J.R., Pangborn W., Gangjee A., Queener S.F.
Acta Crystallogr. D 60:646-655(2004) · UniProtKB (2) |
| Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase. Cody V., Luft J.R., Pangborn W., Gangjee A.
Acta Crystallogr. D 59:1603-1609(2003) · UniProtKB (1) |
| Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase. Cody V., Galitsky N., Luft J.R., Pangborn W., Gangjee A.
Acta Crystallogr. D 59:654-661(2003) · UniProtKB (1) |
| Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase. Cody V., Galitsky N., Luft J.R., Pangborn W., Queener S.F., Gangjee A.
Acta Crystallogr. D 58:1393-1399(2002) · UniProtKB (1) |
| Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH. Cody V., Galitsky N., Luft J.R., Pangborn W., Rosowsky A., Queener S.F.
Acta Crystallogr. D 58:946-954(2002) · UniProtKB (1) |
