1 - 25 of 190 results for author:"Clevers H." in Literature citations
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| Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland. de Visser K.E., Ciampricotti M., Michalak E.M., Tan D.W., Speksnijder E.N., Hau C.S., Clevers H., Barker N., Jonkers J. J. Pathol. 228:300-309(2012) · Mapped (4) |
| Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Koo B.K., Spit M., Jordens I., Low T.Y., Stange D.E., van de Wetering M., van Es J.H., Mohammed S., Heck A.J., Maurice M.M. et al. |
| Chronic epithelial NF-kappaB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Shaked H., Hofseth L.J., Chumanevich A., Chumanevich A.A., Wang J., Wang Y., Taniguchi K., Guma M., Shenouda S., Clevers H. et al. Proc. Natl. Acad. Sci. U.S.A. 109:14007-14012(2012) · Mapped (16) |
| Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Schepers A.G., Snippert H.J., Stange D.E., van den Born M., van Es J.H., van de Wetering M., Clevers H. Science 337:730-735(2012) · Mapped (21) |
| ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Hashimoto T., Perlot T., Rehman A., Trichereau J., Ishiguro H., Paolino M., Sigl V., Hanada T., Hanada R., Lipinski S. et al. Nature 487:477-481(2012) · Mapped (13) |
| Rap2A links intestinal cell polarity to brush border formation. Gloerich M., ten Klooster J.P., Vliem M.J., Koorman T., Zwartkruis F.J., Clevers H., Bos J.L. Nat. Cell Biol. 14:793-801(2012) · Mapped (1) |
| Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". de Lau W., Kujala P., Schneeberger K., Middendorp S., Li V.S., Barker N., Martens A., Hofhuis F., DeKoter R.P., Peters P.J. et al. Mol. Cell. Biol. 32:3639-3647(2012) · Mapped (10) |
| The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. Munoz J., Stange D.E., Schepers A.G., van de Wetering M., Koo B.K., Itzkovitz S., Volckmann R., Kung K.S., Koster J., Radulescu S. et al. EMBO J. 31:3079-3091(2012) · Mapped (4) |
| Wnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex. Li V.S., Ng S.S., Boersema P.J., Low T.Y., Karthaus W.R., Gerlach J.P., Mohammed S., Heck A.J., Maurice M.M., Mahmoudi T. et al. Cell 149:1245-1256(2012) · Mapped (15) |
| A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. van Es J.H., Haegebarth A., Kujala P., Itzkovitz S., Koo B.K., Boj S.F., Korving J., van den Born M., van Oudenaarden A., Robine S. et al. Mol. Cell. Biol. 32:1918-1927(2012) · Mapped (75) |
| Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Wong V.W., Stange D.E., Page M.E., Buczacki S., Wabik A., Itami S., van de Wetering M., Poulsom R., Wright N.A., Trotter M.W. et al. Nat. Cell Biol. 14:401-408(2012) · Mapped (2) |
| Optimality in the development of intestinal crypts. Itzkovitz S., Blat I.C., Jacks T., Clevers H., van Oudenaarden A. Cell 148:608-619(2012) · Mapped (4) |
| Cdx2 determines the fate of postnatal intestinal endoderm. Stringer E.J., Duluc I., Saandi T., Davidson I., Bialecka M., Sato T., Barker N., Clevers H., Pritchard C.A., Winton D.J. et al. Development 139:465-474(2012) · Mapped (20) |
| Single-molecule transcript counting of stem-cell markers in the mouse intestine. Itzkovitz S., Lyubimova A., Blat I.C., Maynard M., van Es J., Lees J., Jacks T., Clevers H., van Oudenaarden A. Nat. Cell Biol. 14:106-114(2012) · Mapped (14) |
| The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis. Sylva M., Li V.S., Buffing A.A., van Es J.H., van den Born M., van der Velden S., Gunst Q., Koolstra J.H., Moorman A.F., Clevers H. et al. PLoS ONE 6:e22616-e22616(2011) · Mapped (36) |
| Comparative proteomics of colon cancer stem cells and differentiated tumor cells identifies BIRC6 as a potential therapeutic target. Van Houdt W.J., Emmink B.L., Pham T.V., Piersma S.R., Verheem A., Vries R.G., Fratantoni S.A., Pronk A., Clevers H., Borel Rinkes I.H. et al. Mol. Cell Proteomics 10:M111.011353-M111.011353(2011) · Mapped (3) |
| Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. de Lau W., Barker N., Low T.Y., Koo B.K., Li V.S., Teunissen H., Kujala P., Haegebarth A., Peters P.J., van de Wetering M. et al. Nature 476:293-297(2011) · Mapped (18) |
| Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-beta-catenin signaling to slow tumor progression. Froeling F.E., Feig C., Chelala C., Dobson R., Mein C.E., Tuveson D.A., Clevers H., Hart I.R., Kocher H.M. Gastroenterology 141:1486-97, 2011:1497.e1-14(2011) · Mapped (9) |
| Actomyosin-mediated cellular tension drives increased tissue stiffness and beta-catenin activation to induce epidermal hyperplasia and tumor growth. Samuel M.S., Lopez J.I., McGhee E.J., Croft D.R., Strachan D., Timpson P., Munro J., Schroder E., Zhou J., Brunton V.G. et al. Cancer Cell 19:776-791(2011) · Mapped (9) |
| Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. Gerbe F., van Es J.H., Makrini L., Brulin B., Mellitzer G., Robine S., Romagnolo B., Shroyer N.F., Bourgaux J.F., Pignodel C. et al. J. Cell Biol. 192:767-780(2011) · Mapped (50) |
| The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish. van der Velden Y.U., Wang L., Zevenhoven J., van Rooijen E., van Lohuizen M., Giles R.H., Clevers H., Haramis A.P. Proc. Natl. Acad. Sci. U.S.A. 108:4358-4363(2011) · Mapped (7) |
| Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Sato T., van Es J.H., Snippert H.J., Stange D.E., Vries R.G., van den Born M., Barker N., Shroyer N.F., van de Wetering M., Clevers H. Nature 469:415-418(2011) · Mapped (50) |
| The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/beta-catenin coactivators essential for intestinal homeostasis. Mahmoudi T., Boj S.F., Hatzis P., Li V.S., Taouatas N., Vries R.G., Teunissen H., Begthel H., Korving J., Mohammed S. et al. PLoS Biol. 8:e1000539-e1000539(2010) · Mapped (50) |
| Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Qiu W., Wang X., Leibowitz B., Liu H., Barker N., Okada H., Oue N., Yasui W., Clevers H., Schoen R.E. et al. Proc. Natl. Acad. Sci. U.S.A. 107:20027-20032(2010) · Mapped (21) |
| p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. Cole A.M., Ridgway R.A., Derkits S.E., Parry L., Barker N., Clevers H., Clarke A.R., Sansom O.J. EMBO Mol Med 2:472-486(2010) · Mapped (10) |