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1 - 25 of 114 results for author:"Chretien M." in Literature citations

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The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.

Seidah N.G., Sadr M.S., Chretien M., Mbikay M.

J. Biol. Chem. 288:21473-21481(2013) · Mapped (2)

Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations.

Mayne J., Ooi T.C., Raymond A., Cousins M., Bernier L., Dewpura T., Sirois F., Mbikay M., Davignon J., Chretien M.

Lipids Health Dis 12:70-70(2013) · Mapped (3)

Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation.

Benjannet S., Hamelin J., Chretien M., Seidah N.G.

J. Biol. Chem. 287:33745-33755(2012) · Mapped (3)

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.

Mayne J., Dewpura T., Raymond A., Bernier L., Cousins M., Ooi T.C., Davignon J., Seidah N.G., Mbikay M., Chretien M.

Clin. Chem. 57:1415-1423(2011) · Mapped (3)

Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells.

Denis N., Palmer-Smith H., Elisma F., Busuttil A., Wright T.G., Bou Khalil M., Prat A., Seidah N.G., Chretien M., Mayne J. et al.

J. Proteome Res. 10:2011-2026(2011) · Mapped (3)

PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides.

Gagnon J., Mayne J., Chen A., Raymond A., Woulfe J., Mbikay M., Chretien M.

Life Sci. 88:212-217(2011) · Mapped (7)

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities.

Mbikay M., Sirois F., Mayne J., Wang G.S., Chen A., Dewpura T., Prat A., Seidah N.G., Chretien M., Scott F.W.

FEBS Lett. 584:701-706(2010) · Mapped (11)

Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.

Gagnon J., Mayne J., Mbikay M., Woulfe J., Chretien M.

Regul. Pept. 152:54-60(2009) · Mapped (9)

Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.

Scamuffa N., Basak A., Lalou C., Wargnier A., Marcinkiewicz J., Siegfried G., Chretien M., Calvo F., Seidah N.G., Khatib A.M.

Gut 57:1573-1582(2008) · Mapped (20)

Ethnic differences in the frequency of the cardioprotective C679X PCSK9 mutation in a West African population.

Sirois F., Gbeha E., Sanni A., Chretien M., Labuda D., Mbikay M.

Genet. Test. 12:377-380(2008) · Mapped (3)

PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans.

Dewpura T., Raymond A., Hamelin J., Seidah N.G., Mbikay M., Chretien M., Mayne J.

FEBS J. 275:3480-3493(2008) · UniProtKB (2) · Mapped (2)

Plasma PCSK9 levels correlate with cholesterol in men but not in women.

Mayne J., Raymond A., Chaplin A., Cousins M., Kaefer N., Gyamera-Acheampong C., Seidah N.G., Mbikay M., Chretien M., Ooi T.C.

Biochem. Biophys. Res. Commun. 361:451-456(2007) · Mapped (3)

A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.

Mbikay M., Croissandeau G., Sirois F., Anini Y., Mayne J., Seidah N.G., Chretien M.

Dev. Biol. 306:584-598(2007) · Mapped (2)

Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2.

Croissandeau G., Wahnon F., Yashpal K., Seidah N.G., Coderre T.J., Chretien M., Mbikay M.

Neurosci. Lett. 406:71-75(2006) · Mapped (7)

Differences of pancreatic expression of 7B2 between C57BL/6J and C3H/HeJ mice and genetic polymorphisms at its locus (Sgne1).

Schmidt G., Sirois F., Anini Y., Kauri L.M., Gyamera-Acheampong C., Fleck E., Scott F.W., Chretien M., Mbikay M.

Diabetes 55:452-459(2006) · Mapped (2)

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse.

Essalmani R., Hamelin J., Marcinkiewicz J., Chamberland A., Mbikay M., Chretien M., Seidah N.G., Prat A.

Mol. Cell. Biol. 26:354-361(2006) · Mapped (2)

Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases.

Tzimas G.N., Chevet E., Jenna S., Nguyen D.T., Khatib A.M., Marcus V., Zhang Y., Chretien M., Seidah N., Metrakos P.

BMC Cancer 5:149-149(2005) · Mapped (2)

Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.

St Germain C., Croissandeau G., Mayne J., Baltz J.M., Chretien M., Mbikay M.

Mol. Reprod. Dev. 72:483-493(2005) · Mapped (34)

Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.

Stawowy P., Meyborg H., Stibenz D., Borges Pereira Stawowy N., Roser M., Thanabalasingam U., Veinot J.P., Chretien M., Seidah N.G., Fleck E. et al.

Circulation 111:2820-2827(2005) · Mapped (10)

Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.

Stawowy P., Kallisch H., Borges Pereira Stawowy N., Stibenz D., Veinot J.P., Grafe M., Seidah N.G., Chretien M., Fleck E., Graf K.

Virchows Arch. 446:351-359(2005) · Mapped (2)

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.

Wickham L., Benjannet S., Marcinkiewicz E., Chretien M., Seidah N.G.

J. Neurochem. 92:93-102(2005) · UniProtKB (2) · Mapped (15)

The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.

Benjannet S., Cromlish J.A., Diallo K., Chretien M., Seidah N.G.

Biochem. Biophys. Res. Commun. 325:235-242(2004) · Mapped (16)

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.

Benjannet S., Rhainds D., Essalmani R., Mayne J., Wickham L., Jin W., Asselin M.C., Hamelin J., Varret M., Allard D. et al.

J. Biol. Chem. 279:48865-48875(2004) · Mapped (5)

Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor.

Stawowy P., Kallisch H., Kilimnik A., Margeta C., Seidah N.G., Chretien M., Fleck E., Graf K.

Biochem. Biophys. Res. Commun. 321:531-538(2004) · Mapped (2)

Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase.

Stawowy P., Margeta C., Kallisch H., Seidah N.G., Chretien M., Fleck E., Graf K.

Cardiovasc. Res. 63:87-97(2004) · Mapped (2)

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