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Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria.

Milenkovic D., Ramming T., Muller J.M., Wenz L.S., Gebert N., Schulze-Specking A., Stojanovski D., Rospert S., Chacinska A.

Mol. Biol. Cell 20:2530-2539(2009) · Mapped (3)

Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import.

Baker M.J., Webb C.T., Stroud D.A., Palmer C.S., Frazier A.E., Guiard B., Chacinska A., Gulbis J.M., Ryan M.T.

Mol. Biol. Cell 20:769-779(2009) · Mapped (2)

Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase.

Stojanovski D., Milenkovic D., Muller J.M., Gabriel K., Schulze-Specking A., Baker M.J., Ryan M.T., Guiard B., Pfanner N., Chacinska A.

J. Cell Biol. 183:195-202(2008) · Mapped (2)

Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40.

Chacinska A., Guiard B., Muller J.M., Schulze-Specking A., Gabriel K., Kutik S., Pfanner N.

J. Biol. Chem. 283:29723-29729(2008) · Mapped (5)

Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase.

Gebert N., Chacinska A., Wagner K., Guiard B., Koehler C.M., Rehling P., Pfanner N., Wiedemann N.

EMBO Rep. 9:548-554(2008) · Mapped (3)

Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase.

Hutu D.P., Guiard B., Chacinska A., Becker D., Pfanner N., Rehling P., van der Laan M.

Mol. Biol. Cell 19:2642-2649(2008) · Mapped (9)

Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space.

Muller J.M., Milenkovic D., Guiard B., Pfanner N., Chacinska A.

Mol. Biol. Cell 19:226-236(2008) · Mapped (2)

Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermembrane space receptor Mia40.

Milenkovic D., Gabriel K., Guiard B., Schulze-Specking A., Pfanner N., Chacinska A.

J. Biol. Chem. 282:22472-22480(2007) · Mapped (4)

The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria.

Meisinger C., Pfannschmidt S., Rissler M., Milenkovic D., Becker T., Stojanovski D., Youngman M.J., Jensen R.E., Chacinska A., Guiard B. et al.

EMBO J. 26:2229-2239(2007) · UniProtKB (3) · Mapped (11)

Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins.

Sanjuan Szklarz L.K., Kozjak-Pavlovic V., Vogtle F.N., Chacinska A., Milenkovic D., Vogel S., Durr M., Westermann B., Guiard B., Martinou J.C. et al.

J. Mol. Biol. 368:44-54(2007) · Mapped (35)

The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes.

Albrecht R., Rehling P., Chacinska A., Brix J., Cadamuro S.A., Volkmer R., Guiard B., Pfanner N., Zeth K.

EMBO Rep. 7:1233-1238(2006) · Mapped (3)

Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway.

Gabriel K., Milenkovic D., Chacinska A., Mueller J., Guiard B., Pfanner N., Meisinger C.

J. Mol. Biol. 365:612-620(2007) · UniProtKB (3) · Mapped (9)

Tim50 maintains the permeability barrier of the mitochondrial inner membrane.

Meinecke M., Wagner R., Kovermann P., Guiard B., Mick D.U., Hutu D.P., Voos W., Truscott K.N., Chacinska A., Pfanner N. et al.

Science 312:1523-1526(2006) · Mapped (7)

The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins.

Rissler M., Wiedemann N., Pfannschmidt S., Gabriel K., Guiard B., Pfanner N., Chacinska A.

J. Mol. Biol. 353:485-492(2005) · UniProtKB (2) · Mapped (4)

Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor.

van der Laan M., Chacinska A., Lind M., Perschil I., Sickmann A., Meyer H.E., Guiard B., Meisinger C., Pfanner N., Rehling P.

Mol. Cell. Biol. 25:7449-7458(2005) · UniProtKB (6) · Mapped (4)

Inactivation of the mitochondrial heat shock protein Zim17 leads to aggregation of matrix Hsp70s followed by pleiotropic effects on morphology and protein biogenesis.

Sanjuan Szklarz L.K., Guiard B., Rissler M., Wiedemann N., Kozjak V., van der Laan M., Lohaus C., Marcus K., Meyer H.E., Chacinska A. et al.

J. Mol. Biol. 351:206-218(2005) · UniProtKB (1) · Mapped (11)

Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.

Chacinska A., Lind M., Frazier A.E., Dudek J., Meisinger C., Geissler A., Sickmann A., Meyer H.E., Truscott K.N., Guiard B. et al.

Cell 120:817-829(2005) · UniProtKB (4) · Mapped (2)

Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins.

Chacinska A., Pfannschmidt S., Wiedemann N., Kozjak V., Sanjuan Szklarz L.K., Schulze-Specking A., Truscott K.N., Guiard B., Meisinger C., Pfanner N.

EMBO J. 23:3735-3746(2004) · UniProtKB (1) · Mapped (2)

The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane.

Meisinger C., Rissler M., Chacinska A., Szklarz L.K., Milenkovic D., Kozjak V., Schonfisch B., Lohaus C., Meyer H.E., Yaffe M.P. et al.

Dev. Cell 7:61-71(2004) · UniProtKB (1) · Mapped (5)

Mutations in the yeast mrf1 gene encoding mitochondrial release factor inhibit translation on mitochondrial ribosomes.

Towpik J., Chacinska A., Ciesla M., Ginalski K., Boguta M.

J. Biol. Chem. 279:14096-14103(2004) · Mapped (1)

The proteome of Saccharomyces cerevisiae mitochondria.

Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B. et al.

Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) · UniProtKB (221) · Mapped (571)

Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space.

Frazier A.E., Chacinska A., Truscott K.N., Guiard B., Pfanner N., Rehling P.

Mol. Cell. Biol. 23:7818-7828(2003) · Mapped (4)

Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex.

Chacinska A., Rehling P., Guiard B., Frazier A.E., Schulze-Specking A., Pfanner N., Voos W., Meisinger C.

EMBO J. 22:5370-5381(2003) · UniProtKB (1) · Mapped (3)

Machinery for protein sorting and assembly in the mitochondrial outer membrane.

Wiedemann N., Kozjak V., Chacinska A., Schoenfisch B., Rospert S., Ryan M.T., Pfanner N., Meisinger C.

Nature 424:565-571(2003) · UniProtKB (2) · Mapped (5)

The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel.

Geissler A., Chacinska A., Truscott K.N., Wiedemann N., Brandner K., Sickmann A., Meyer H.E., Meisinger C., Pfanner N., Rehling P.

Cell 111:507-518(2002) · UniProtKB (1) · Mapped (2)

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