1 - 25 of 137 results for author:"Cantley L.C." in Literature citations
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| ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Yang W., Zheng Y., Xia Y., Ji H., Chen X., Guo F., Lyssiotis C.A., Aldape K., Cantley L.C., Lu Z. Nat. Cell Biol. 14:1295-1304(2012) · Mapped (8) |
| Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Das S., Aiba T., Rosenberg M., Hessler K., Xiao C., Quintero P.A., Ottaviano F.G., Knight A.C., Graham E.L., Bostrom P. et al. Circulation 126:2208-2219(2012) · Mapped (9) |
| Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. Kung C., Hixon J., Choe S., Marks K., Gross S., Murphy E., DeLaBarre B., Cianchetta G., Sethumadhavan S., Wang X. et al. Chem. Biol. 19:1187-1198(2012) · Mapped (1) |
| Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Anastasiou D., Yu Y., Israelsen W.J., Jiang J.K., Boxer M.B., Hong B.S., Tempel W., Dimov S., Shen M., Jha A. et al. Nat. Chem. Biol. 8:839-847(2012) · Mapped (1) |
| p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Dagon Y., Hur E., Zheng B., Wellenstein K., Cantley L.C., Kahn B.B. Cell Metab. 16:104-112(2012) · Mapped (9) |
| IkappaB kinase alpha phosphorylation of TRAF4 downregulates innate immune signaling. Marinis J.M., Hutti J.E., Homer C.R., Cobb B.A., Cantley L.C., McDonald C., Abbott D.W. Mol. Cell. Biol. 32:2479-2489(2012) · Mapped (13) |
| Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Ying H., Kimmelman A.C., Lyssiotis C.A., Hua S., Chu G.C., Fletcher-Sananikone E., Locasale J.W., Son J., Zhang H., Coloff J.L. et al. Cell 149:656-670(2012) · Mapped (18) |
| A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Chen Z., Cheng K., Walton Z., Wang Y., Ebi H., Shimamura T., Liu Y., Tupper T., Ouyang J., Li J. et al. Nature 483:613-617(2012) · Mapped (23) |
| Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Garcia-Cao I., Song M.S., Hobbs R.M., Laurent G., Giorgi C., de Boer V.C., Anastasiou D., Ito K., Sasaki A.T., Rameh L. et al. Cell 149:49-62(2012) · Mapped (5) |
| Characterization of KRAS rearrangements in metastatic prostate cancer. Wang X.S., Shankar S., Dhanasekaran S.M., Ateeq B., Sasaki A.T., Jing X., Robinson D., Cao Q., Prensner J.R., Yocum A.K. et al. Cancer Discov 1:35-43(2011) · Mapped (10) |
| Chemical genetic screen for AMPKalpha2 substrates uncovers a network of proteins involved in mitosis. Banko M.R., Allen J.J., Schaffer B.E., Wilker E.W., Tsou P., White J.L., Villen J., Wang B., Kim S.R., Sakamoto K. et al. Mol. Cell 44:878-892(2011) · Mapped (3) |
| Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Anastasiou D., Poulogiannis G., Asara J.M., Boxer M.B., Jiang J.K., Shen M., Bellinger G., Sasaki A.T., Locasale J.W., Auld D.S. et al. Science 334:1278-1283(2011) · Mapped (8) |
| Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. Wang Z., Chatterjee D., Jeon H.Y., Akerman M., Vander Heiden M.G., Cantley L.C., Krainer A.R. J Mol Cell Biol 4:79-87(2012) · Mapped (8) |
| mTOR drives its own activation via SCF(betaTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Gao D., Inuzuka H., Tan M.K., Fukushima H., Locasale J.W., Liu P., Wan L., Zhai B., Chin Y.R., Shaik S. et al. Mol. Cell 44:290-303(2011) · Mapped (14) |
| Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. Ebi H., Corcoran R.B., Singh A., Chen Z., Song Y., Lifshits E., Ryan D.P., Meyerhardt J.A., Benes C., Settleman J. et al. J. Clin. Invest. 121:4311-4321(2011) · Mapped (7) |
| High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cheung L.W., Hennessy B.T., Li J., Yu S., Myers A.P., Djordjevic B., Lu Y., Stemke-Hale K., Dyer M.D., Zhang F. et al. Cancer Discov 1:170-185(2011) · Mapped (13) |
| PHGDH amplification and altered glucose metabolism in human melanoma. Mullarky E., Mattaini K.R., Vander Heiden M.G., Cantley L.C., Locasale J.W. Pigment Cell Melanoma Res 24:1112-1115(2011) · Mapped (11) |
| Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Yi C.H., Pan H., Seebacher J., Jang I.H., Hyberts S.G., Heffron G.J., Vander Heiden M.G., Yang R., Li F., Locasale J.W. et al. Cell 146:607-620(2011) · Mapped (2) |
| Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains. Lee J.Y., Chiu Y.H., Asara J., Cantley L.C. Proc. Natl. Acad. Sci. U.S.A. 108:14157-14162(2011) · Mapped (7) |
| Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Locasale J.W., Grassian A.R., Melman T., Lyssiotis C.A., Mattaini K.R., Bass A.J., Heffron G., Metallo C.M., Muranen T., Sharfi H. et al. Nat. Genet. 43:869-874(2011) · Mapped (11) |
| The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility. Benes C.H., Poulogiannis G., Cantley L.C., Soltoff S.P. Oncogene 31:653-663(2012) · Mapped (3) |
| Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Yu Y., Yoon S.O., Poulogiannis G., Yang Q., Ma X.M., Villen J., Kubica N., Hoffman G.R., Cantley L.C., Gygi S.P. et al. Science 332:1322-1326(2011) · Mapped (3) |
| TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. Bouskila M., Esoof N., Gay L., Fang E.H., Deak M., Begley M.J., Cantley L.C., Prescott A., Storey K.G., Alessi D.R. Biochem. J. 437:157-167(2011) · UniProtKB (1) |
| Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Saci A., Cantley L.C., Carpenter C.L. Mol. Cell 42:50-61(2011) · Mapped (12) |
| Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. Sasaki A.T., Carracedo A., Locasale J.W., Anastasiou D., Takeuchi K., Kahoud E.R., Haviv S., Asara J.M., Pandolfi P.P., Cantley L.C. Sci Signal 4:ra13-ra13(2011) · Mapped (7) |