| Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition. Faucher F., Cantin L., Luu-The V., Labrie F., Breton R.
Biochemistry 47:13537-13546(2008) · Mapped (5) |
| The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. Faucher F., Cantin L., Luu-The V., Labrie F., Breton R.
Biochemistry 47:8261-8270(2008) · Mapped (1) |
| Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12. Cantin L., Faucher F., Couture J.-F., de Jesus-Tran K.P., Legrand P., Ciobanu L.C., Frechette Y., Labrecque R., Singh S.M., Labrie F. et al.
J. Biol. Chem. 282:30910-30919(2007) · UniProtKB (1) |
| Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. Faucher F., Cantin L., Pereira de Jesus-Tran K., Lemieux M., Luu-The V., Labrie F., Breton R.
J. Mol. Biol. 369:525-540(2007) · UniProtKB (1) · Mapped (1) |
| Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme. Faucher F., Pereira de Jesus-Tran K., Cantin L., Luu-The V., Labrie F., Breton R.
J. Mol. Biol. 364:747-763(2006) · UniProtKB (1) · Mapped (1) |
| Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity. Pereira de Jesus-Tran K., Cote P.-L., Cantin L., Blanchet J., Labrie F., Breton R.
Protein Sci. 15:987-999(2006) · UniProtKB (1) · Mapped (10) |
| Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17-alpha-HSD) and its involvement in the biosynthesis of epitestosterone. Bellemare V., Faucher F., Breton R., Luu-The V.
BMC Biochem. 6:12-12(2005) · UniProtKB (1) |
| Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen. Couture J.F., de Jesus-Tran K.P., Roy A.M., Cantin L., Cote P.L., Legrand P., Luu-The V., Labrie F., Breton R.
Protein Sci. 14:1485-1497(2005) · Mapped (1) |
| Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2. Dumont M., Frank D., Moisan A.-M., Tranchant M., Soucy P., Breton R., Labrie F., Tavtigian S.V., Simard J.
Biochim. Biophys. Acta 1679:230-247(2004) · UniProtKB (3) · Mapped (1) |
| Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily. Couture J.-F., Legrand P., Cantin L., Labrie F., Luu-The V., Breton R.
J. Mol. Biol. 339:89-102(2004) · UniProtKB (1) |
| The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents. Richard M., Thibault N., Veilleux P., Breton R., Beaulieu A.D.
Biochem. Biophys. Res. Commun. 310:767-773(2003) · Mapped (1) |
| Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids. Couture J.-F., Legrand P., Cantin L., Luu-The V., Labrie F., Breton R.
J. Mol. Biol. 331:593-604(2003) · UniProtKB (1) |
| Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution. Nahoum V., Gangloff A., Legrand P., Zhu D.-W., Cantin L., Zhorov B.S., Luu-The V., Labrie F., Breton R., Lin S.X.
J. Biol. Chem. 276:42091-42098(2001) · UniProtKB (1) |
| The Rac GTPase-activating protein RotundRacGAP interferes with Drac1 and Dcdc42 signalling in Drosophila melanogaster. Raymond K., Bergeret E., Dagher M.C., Breton R., Griffin-Shea R., Fauvarque M.O.
J. Biol. Chem. 276:35909-35916(2001) · Mapped (15) |
| Modulation of 17alpha-hydroxylase/17,20-lyase activity of guinea pig cytochrome P450c17 by site-directed mutagenesis. Beaudoin C., Lavallee B., Tremblay Y., Hum D.W., Breton R., de Launoit Y., Belanger A.
DNA Cell Biol. 17:707-715(1998) · Mapped (6) |
| Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase. Mazza C., Breton R., Housset D., Fontecilla-Camps J.-C.
J. Biol. Chem. 273:8145-8152(1998) · UniProtKB (1) |
| The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors. Breton R., Housset D., Mazza C., Fontecilla-Camps J.-C.
Structure 4:905-915(1996) · UniProtKB (1) |
| Clustering and co-transcription of the Bacillus subtilis genes encoding the aminoacyl-tRNA synthetases specific for glutamate and for cysteine and the first enzyme for cysteine biosynthesis. Gagnon Y., Breton R., Putzer H., Pelchat M., Grunberg-Manago M., Lapointe J.
J. Biol. Chem. 269:7473-7482(1994) · UniProtKB (7) |
| Glutamyl-tRNA synthetase of Escherichia coli. Isolation and primary structure of the gltX gene and homology with other aminoacyl-tRNA synthetases. Breton R., Sanfacon H., Papayannopoulos I., Biemann K., Lapointe J.
J. Biol. Chem. 261:10610-10617(1986) · UniProtKB (2) |
| Closely spaced and divergent promoters for an aminoacyl-tRNA synthetase gene and a tRNA operon in Escherichia coli. Transcriptional and post-transcriptional regulation of gltX, valU and alaW. Brun V., Sanfacon H., Breton R., Lapointe J.
J. Mol. Biol. 214:845-864(1990) · UniProtKB (1) |
| Precise mapping and comparison of two evolutionarily related regions of the Escherichia coli K-12 chromosome. Evolution of valU and lysT from an ancestral tRNA operon. Brun Y.V., Breton R., Lanouette P., Lapointe J.
J. Mol. Biol. 214:825-843(1990) · UniProtKB (6) |
| Glutamyl-tRNA synthetases of Bacillus subtilis 168T and of Bacillus stearothermophilus. Cloning and sequencing of the gltX genes and comparison with other aminoacyl-tRNA synthetases. Breton R., Watson D., Yaguchi M., Lapointe J.
J. Biol. Chem. 265:18248-18255(1990) · UniProtKB (2) · Mapped (1) |
| Adenylosuccinate lyase of Bacillus subtilis regulates the activity of the glutamyl-tRNA synthetase. Gendron N., Breton R., Champagne N., Lapointe J.
Proc. Natl. Acad. Sci. U.S.A. 89:5389-5392(1992) · UniProtKB (1) |
