| The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Castell A., Short F.L., Evans G.L., Cookson T.V., Bulloch E.M., Joseph D.D., Lee C.E., Parker E.J., Baker E.N., Lott J.S.
Biochemistry 0:0-0(2013) · Mapped (1) |
| Three sites and you are out: ternary synergistic allostery controls aromatic amino Acid biosynthesis in mycobacteriumtuberculosis. Blackmore N.J., Reichau S., Jiao W., Hutton R.D., Baker E.N., Jameson G.B., Parker E.J.
J. Mol. Biol. 425:1582-1592(2013) · Mapped (1) |
| Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism. Bunker R.D., Bulloch E.M., Dickson J.M., Loomes K.M., Baker E.N.
J. Biol. Chem. 288:1643-1652(2013) · UniProtKB (1) · Mapped (3) |
| Use of a repetitive seeding protocol to obtain diffraction-quality crystals of a putative human D-xylulokinase. Bunker R.D., Dickson J.M., Caradoc-Davies T.T., Loomes K.M., Baker E.N.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68:1259-1262(2012) · Mapped (4) |
| The extracellular protein factor Epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an N-terminal domain containing a carbohydrate-binding module. Linke C., Siemens N., Oehmcke S., Radjainia M., Law R.H., Whisstock J.C., Baker E.N., Kreikemeyer B.
J. Biol. Chem. 287:38178-38189(2012) · UniProtKB (1) |
| Structural and functional properties of staphylococcal superantigen-like protein 4. Hermans S.J., Baker H.M., Sequeira R.P., Langley R.J., Baker E.N., Fraser J.D.
Infect. Immun. 80:4004-4013(2012) · UniProtKB (1) |
| Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis. Chi G., Manos-Turvey A., O'Connor P.D., Johnston J.M., Evans G.L., Baker E.N., Payne R.J., Lott J.S., Bulloch E.M.
Biochemistry 51:4868-4879(2012) · Mapped (1) |
| Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis. Coulibaly F., Lassalle E., Baker H.M., Baker E.N.
Acta Crystallogr. D 68:553-563(2012) · UniProtKB (1) |
| Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding. Huisman F.H., Koon N., Bulloch E.M., Baker H.M., Baker E.N., Squire C.J., Parker E.J.
Biochemistry 51:2289-2297(2012) · Mapped (2) |
| Purification, crystallization and preliminary crystallographic analysis of human dihydrodipicolinate synthase-like protein (DHDPSL). Bunker R.D., Loomes K.M., Baker E.N.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68:59-62(2012) · Mapped (1) |
| Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis. Rehan A.M., Bashiri G., Paterson N.G., Baker E.N., Squire C.J.
Acta Crystallogr. F 67:1274-1277(2011) · UniProtKB (1) |
| Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide. Le Nours J., Bulloch E.M., Zhang Z., Greenwood D.R., Middleditch M.J., Dickson J.M., Baker E.N.
J. Biol. Chem. 286:40706-40716(2011) · Mapped (1) |
| Structure of the full-length major pilin from Streptococcus pneumoniae: implications for isopeptide bond formation in gram-positive bacterial pili. Paterson N.G., Baker E.N.
PLoS ONE 6:e22095-e22095(2011) · UniProtKB (1) |
| Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design. Reichau S., Jiao W., Walker S.R., Hutton R.D., Baker E.N., Parker E.J.
J. Biol. Chem. 286:16197-16207(2011) · Mapped (1) |
| Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis. Johnston J.M., Jiang M., Guo Z., Baker E.N.
Acta Crystallogr. D 66:909-917(2010) · UniProtKB (1) |
| Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis. Webby C.J., Jiao W., Hutton R.D., Blackmore N.J., Baker H.M., Baker E.N., Jameson G.B., Parker E.J.
J. Biol. Chem. 285:30567-30576(2010) · Mapped (1) |
| Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI). Manos-Turvey A., Bulloch E.M., Rutledge P.J., Baker E.N., Lott J.S., Payne R.J.
ChemMedChem 5:1067-1079(2010) · Mapped (1) |
| Crystal structure of the minor pilin FctB reveals determinants of Group A streptococcal pilus anchoring. Linke C., Young P.G., Kang H.J., Bunker R.D., Middleditch M.J., Caradoc-Davies T.T., Proft T., Baker E.N.
J. Biol. Chem. 285:20381-20389(2010) · UniProtKB (1) |
| Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis. Watkins H.A., Baker E.N.
J. Bacteriol. 192:2878-2886(2010) · Mapped (2) |
| The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds. Kang H.J., Paterson N.G., Gaspar A.H., Ton-That H., Baker E.N.
Proc. Natl. Acad. Sci. U.S.A. 106:16967-16971(2009) · UniProtKB (1) |
| The laminin-binding protein Lbp from Streptococcus pyogenes is a zinc receptor. Linke C., Caradoc-Davies T.T., Young P.G., Proft T., Baker E.N.
J. Bacteriol. 191:5814-5823(2009) · UniProtKB (1) |
| Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes. Sun X., Baker H.M., Ge R., Sun H., He Q.Y., Baker E.N.
Biochemistry 48:6184-6190(2009) · Mapped (1) |
| The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily. Young P.G., Walanj R., Lakshmi V., Byrnes L.J., Metcalf P., Baker E.N., Vakulenko S.B., Smith C.A.
J. Bacteriol. 191:4133-4143(2009) · UniProtKB (1) |
| Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery. Zhang Z., Caradoc-Davies T.T., Dickson J.M., Baker E.N., Squire C.J.
J. Mol. Biol. 389:722-733(2009) · UniProtKB (1) |
| Structure and function of GlmU from Mycobacterium tuberculosis. Zhang Z., Bulloch E.M., Bunker R.D., Baker E.N., Squire C.J.
Acta Crystallogr. D 65:275-283(2009) · UniProtKB (1) |
