1 - 25 of 40 results for author:"Backer J.M." in Literature citations
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| Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2beta. Cai X., Srivastava S., Sun Y., Li Z., Wu H., Zuvela-Jelaska L., Li J., Salamon R.S., Backer J.M., Skolnik E.Y. Proc. Natl. Acad. Sci. U.S.A. 108:20072-20077(2011) · UniProtKB (1) · Mapped (13) |
| Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. Yoon M.S., Du G., Backer J.M., Frohman M.A., Chen J. J. Cell Biol. 195:435-447(2011) · Mapped (23) |
| Targeted systemic radiotherapy with scVEGF/177Lu leads to sustained disruption of the tumor vasculature and intratumoral apoptosis. Blankenberg F.G., Levashova Z., Goris M.G., Hamby C.V., Backer M.V., Backer J.M. J. Nucl. Med. 52:1630-1637(2011) · Mapped (1) |
| Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis. Smirnova T., Zhou Z.N., Flinn R.J., Wyckoff J., Boimel P.J., Pozzuto M., Coniglio S.J., Backer J.M., Bresnick A.R., Condeelis J.S. et al. Oncogene 31:706-715(2012) · Mapped (16) |
| A beta version of life: p110beta takes center stage. Dbouk H.A., Backer J.M. |
| A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase. Dbouk H.A., Pang H., Fiser A., Backer J.M. Proc. Natl. Acad. Sci. U.S.A. 107:19897-19902(2010) · UniProtKB (1) · Mapped (5) |
| The late endosome is essential for mTORC1 signaling. Flinn R.J., Yan Y., Goswami S., Parker P.J., Backer J.M. Mol. Biol. Cell 21:833-841(2010) · Mapped (11) |
| Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Jaiswal B.S., Janakiraman V., Kljavin N.M., Chaudhuri S., Stern H.M., Wang W., Kan Z., Dbouk H.A., Peters B.A., Waring P. et al. Cancer Cell 16:463-474(2009) · Mapped (6) |
| Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants. Wu H., Shekar S.C., Flinn R.J., El-Sibai M., Jaiswal B.S., Sen K.I., Janakiraman V., Seshagiri S., Gerfen G.J., Girvin M.E. et al. Proc. Natl. Acad. Sci. U.S.A. 106:20258-20263(2009) · Mapped (4) |
| Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Pang H., Flinn R., Patsialou A., Wyckoff J., Roussos E.T., Wu H., Pozzuto M., Goswami S., Condeelis J.S., Bresnick A.R. et al. Cancer Res. 69:8868-8876(2009) · Mapped (7) |
| Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Zhong Y., Wang Q.J., Li X., Yan Y., Backer J.M., Chait B.T., Heintz N., Yue Z. Nat. Cell Biol. 11:468-476(2009) · UniProtKB (3) · Mapped (7) |
| hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells. Yan Y., Flinn R.J., Wu H., Schnur R.S., Backer J.M. Biochem. J. 417:747-755(2009) · Mapped (5) |
| Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Ciraolo E., Iezzi M., Marone R., Marengo S., Curcio C., Costa C., Azzolino O., Gonella C., Rubinetto C., Wu H. et al. Sci Signal 1:ra3-ra3(2008) · Mapped (6) |
| The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. Juhasz G., Hill J.H., Yan Y., Sass M., Baehrecke E.H., Backer J.M., Neufeld T.P. J. Cell Biol. 181:655-666(2008) · Mapped (35) |
| VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation. Saban M.R., Backer J.M., Backer M.V., Maier J., Fowler B., Davis C.A., Simpson C., Wu X.R., Birder L., Freeman M.R. et al. Am. J. Physiol. Renal Physiol. 295:F60-72(2008) · Mapped (14) |
| WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells. Sarmiento C., Wang W., Dovas A., Yamaguchi H., Sidani M., El-Sibai M., Desmarais V., Holman H.A., Kitchen S., Backer J.M. et al. J. Cell Biol. 180:1245-1260(2008) · Mapped (1) |
| In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation. Weinger J.G., Gohari P., Yan Y., Backer J.M., Varnum B., Shafit-Zagardo B. J. Neurochem. 106:134-146(2008) · UniProtKB (1) · Mapped (20) |
| The regulation and function of Class III PI3Ks: novel roles for Vps34. Backer J.M. Biochem. J. 410:1-17(2008) · Mapped (1) |
| Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. El-Sibai M., Nalbant P., Pang H., Flinn R.J., Sarmiento C., Macaluso F., Cammer M., Condeelis J.S., Hahn K.M., Backer J.M. J. Cell. Sci. 120:3465-3474(2007) · Mapped (5) |
| Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Miled N., Yan Y., Hon W.C., Perisic O., Zvelebil M., Inbar Y., Schneidman-Duhovny D., Wolfson H.J., Backer J.M., Williams R.L. |
| The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration. Chuang Y.Y., Valster A., Coniglio S.J., Backer J.M., Symons M. J. Cell. Sci. 120:1927-1934(2007) · Mapped (1) |
| Regulation of class III (Vps34) PI3Ks. Yan Y., Backer J.M. Biochem. Soc. Trans. 35:239-241(2007) · Mapped (1) |
| Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells. Srivastava S., Li Z., Ko K., Choudhury P., Albaqumi M., Johnson A.K., Yan Y., Backer J.M., Unutmaz D., Coetzee W.A. et al. |
| Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Nobukuni T., Joaquin M., Roccio M., Dann S.G., Kim S.Y., Gulati P., Byfield M.P., Backer J.M., Natt F., Bos J.L. et al. Proc. Natl. Acad. Sci. U.S.A. 102:14238-14243(2005) · Mapped (2) |
| hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. Byfield M.P., Murray J.T., Backer J.M. J. Biol. Chem. 280:33076-33082(2005) · Mapped (15) |