1 - 25 of 47 results for author:"Aplan P.D." in Literature citations
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| Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13-driven mouse model. Xu H., Menendez S., Schlegelberger B., Bae N., Aplan P.D., Gohring G., Deblasio T.R., Nimer S.D. Blood 120:3089-3097(2012) · Mapped (18) |
| Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome. Slape C.I., Saw J., Jowett J.B., Aplan P.D., Strasser A., Jane S.M., Curtis D.J. Blood 120:2475-2483(2012) · Mapped (12) |
| Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma. Beachy S.H., Onozawa M., Chung Y.J., Slape C., Bilke S., Francis P., Pineda M., Walker R.L., Meltzer P., Aplan P.D. Blood 120:1048-1059(2012) · Mapped (1) |
| NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights. Gough S.M., Slape C.I., Aplan P.D. Blood 118:6247-6257(2011) · Mapped (4) |
| Chromatin remodeling complex NURF regulates thymocyte maturation. Landry J.W., Banerjee S., Taylor B., Aplan P.D., Singer A., Wu C. Genes Dev. 25:275-286(2011) · Mapped (13) |
| The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr. Castiel A., Danieli M.M., David A., Moshkovitz S., Aplan P.D., Kirsch I.R., Brandeis M., Kramer A., Izraeli S. J. Cell. Sci. 124:532-539(2011) · Mapped (12) |
| The TLX1 oncogene drives aneuploidy in T cell transformation. De Keersmaecker K., Real P.J., Gatta G.D., Palomero T., Sulis M.L., Tosello V., Van Vlierberghe P., Barnes K., Castillo M., Sole X. et al. Nat. Med. 16:1321-1327(2010) · Mapped (1) |
| Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes. Tremblay M., Tremblay C.S., Herblot S., Aplan P.D., Hebert J., Perreault C., Hoang T. Genes Dev. 24:1093-1105(2010) · Mapped (30) |
| Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice. Caudell D., Harper D.P., Novak R.L., Pierce R.M., Slape C., Wolff L., Aplan P.D. Blood 115:1194-1203(2010) · Mapped (6) |
| A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Lin Y.W., Beharry Z.M., Hill E.G., Song J.H., Wang W., Xia Z., Zhang Z., Aplan P.D., Aster J.C., Smith C.D. et al. Blood 115:824-833(2010) · Mapped (11) |
| A NUP98-HOXD13 fusion gene impairs differentiation of B and T lymphocytes and leads to expansion of thymocytes with partial TCRB gene rearrangement. Choi C.W., Chung Y.J., Slape C., Aplan P.D. J. Immunol. 183:6227-6235(2009) · Mapped (1) |
| Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Stumpo D.J., Broxmeyer H.E., Ward T., Cooper S., Hangoc G., Chung Y.J., Shelley W.C., Richfield E.K., Ray M.K., Yoder M.C. et al. Blood 114:2401-2410(2009) · Mapped (37) |
| The mitotic checkpoint gene, SIL is regulated by E2F1. Erez A., Chaussepied M., Castiel A., Colaizzo-Anas T., Aplan P.D., Ginsberg D., Izraeli S. Int. J. Cancer 123:1721-1725(2008) · Mapped (2) |
| Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl. Slape C., Liu L.Y., Beachy S., Aplan P.D. Blood 112:2017-2019(2008) · Mapped (19) |
| The role of CALM-AF10 gene fusion in acute leukemia. Caudell D., Aplan P.D. Leukemia 22:678-685(2008) · Mapped (6) |
| Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice. Caudell D., Zhang Z., Chung Y.J., Aplan P.D. Cancer Res. 67:8022-8031(2007) · Mapped (6) |
| Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation. Slape C., Hartung H., Lin Y.W., Bies J., Wolff L., Aplan P.D. Cancer Res. 67:5148-5155(2007) · Mapped (1) |
| p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis. Fasseu M., Aplan P.D., Chopin M., Boissel N., Bories J.C., Soulier J., von Boehmer H., Sigaux F., Regnault A. Blood 110:2610-2619(2007) · Mapped (10) |
| Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition. Cheng Y., Zhang Z., Slape C., Aplan P.D. Neoplasia 9:315-321(2007) · Mapped (13) |
| Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. Lin Y.W., Nichols R.A., Letterio J.J., Aplan P.D. Blood 107:2540-2543(2006) · Mapped (3) |
| OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1. Lin Y.W., Deveney R., Barbara M., Iscove N.N., Nimer S.D., Slape C., Aplan P.D. Cancer Res. 65:7151-7158(2005) · Mapped (7) |
| The role of NUP98 gene fusions in hematologic malignancy. Slape C., Aplan P.D. Leuk. Lymphoma 45:1341-1350(2004) · Mapped (4) |
| Loss of Smad3 in acute T-cell lymphoblastic leukemia. Wolfraim L.A., Fernandez T.M., Mamura M., Fuller W.L., Kumar R., Cole D.E., Byfield S., Felici A., Flanders K.C., Walz T.M. et al. N. Engl. J. Med. 351:552-559(2004) · Mapped (10) |
| NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation. Gurevich R.M., Aplan P.D., Humphries R.K. Blood 104:1127-1136(2004) · Mapped (5) |
| Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis. Levantini E., Giorgetti A., Cerisoli F., Traggiai E., Guidi A., Martin R., Acampora D., Aplan P.D., Keller G., Simeone A. et al. Proc. Natl. Acad. Sci. U.S.A. 100:10299-10303(2003) · Mapped (9) |