1 - 25 of 109 results for author:"Alessi D.R." in Literature citations
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| Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors. Najafov A., Shpiro N., Alessi D.R. Biochem. J. 448:285-295(2012) · Mapped (9) |
| Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production. Landego I., Jayachandran N., Wullschleger S., Zhang T.T., Gibson I.W., Miller A., Alessi D.R., Marshall A.J. Eur. J. Immunol. 42:2760-2770(2012) · Mapped (7) |
| Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. Castaneda-Bueno M., Cervantes-Perez L.G., Vazquez N., Uribe N., Kantesaria S., Morla L., Bobadilla N.A., Doucet A., Alessi D.R., Gamba G. Proc. Natl. Acad. Sci. U.S.A. 109:7929-7934(2012) · Mapped (8) |
| Discovery of potent and selective covalent inhibitors of JNK. Zhang T., Inesta-Vaquera F., Niepel M., Zhang J., Ficarro S.B., Machleidt T., Xie T., Marto J.A., Kim N., Sim T. et al. Chem. Biol. 19:140-154(2012) · Mapped (1) |
| TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. Bouskila M., Esoof N., Gay L., Fang E.H., Deak M., Begley M.J., Cantley L.C., Prescott A., Storey K.G., Alessi D.R. Biochem. J. 437:157-167(2011) · UniProtKB (1) |
| Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. Chiga M., Rafiqi F.H., Alessi D.R., Sohara E., Ohta A., Rai T., Sasaki S., Uchida S. J. Cell. Sci. 124:1391-1395(2011) · Mapped (19) |
| Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. Loffler A.S., Alers S., Dieterle A.M., Keppeler H., Franz-Wachtel M., Kundu M., Campbell D.G., Wesselborg S., Alessi D.R., Stork B. |
| MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases. Filippi B.M., de los Heros P., Mehellou Y., Navratilova I., Gourlay R., Deak M., Plater L., Toth R., Zeqiraj E., Alessi D.R. EMBO J. 30:1730-1741(2011) · Mapped (4) |
| Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Pearce L.R., Sommer E.M., Sakamoto K., Wullschleger S., Alessi D.R. Biochem. J. 436:169-179(2011) · Mapped (7) |
| Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. Richardson C., Sakamoto K., de los Heros P., Deak M., Campbell D.G., Prescott A.R., Alessi D.R. J. Cell. Sci. 124:789-800(2011) · Mapped (15) |
| Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis. Wullschleger S., Wasserman D.H., Gray A., Sakamoto K., Alessi D.R. Biochem. J. 434:265-274(2011) · Mapped (7) |
| How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance. Wullschleger S., Sakamoto K., Johnstone L., Duce S., Fleming S., Alessi D.R. Dis Model Mech 4:95-103(2011) · Mapped (20) |
| Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells. Finlay D.K., Kelly A.P., Clarke R., Sinclair L.V., Deak M., Alessi D.R., Cantrell D.A. J. Immunol. 185:5973-5982(2010) · Mapped (12) |
| Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry. Pozo-Guisado E., Campbell D.G., Deak M., Alvarez-Barrientos A., Morrice N.A., Alvarez I.S., Alessi D.R., Martin-Romero F.J. J. Cell. Sci. 123:3084-3093(2010) · Mapped (12) |
| 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Nichols R.J., Dzamko N., Morrice N.A., Campbell D.G., Deak M., Ordureau A., Macartney T., Tong Y., Shen J., Prescott A.R. et al. Biochem. J. 430:393-404(2010) · Mapped (6) |
| New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Zagorska A., Deak M., Campbell D.G., Banerjee S., Hirano M., Aizawa S., Prescott A.R., Alessi D.R. |
| Role of the WNK-activated SPAK kinase in regulating blood pressure. Rafiqi F.H., Zuber A.M., Glover M., Richardson C., Fleming S., Jovanovic S., Jovanovic A., O'Shaughnessy K.M., Alessi D.R. EMBO Mol Med 2:63-75(2010) · Mapped (9) |
| Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation. Sanchez Canedo C., Demeulder B., Ginion A., Bayascas J.R., Balligand J.L., Alessi D.R., Vanoverschelde J.L., Beauloye C., Hue L., Bertrand L. Am. J. Physiol. Endocrinol. Metab. 298:E761-9(2010) · Mapped (13) |
| Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Zeqiraj E., Filippi B.M., Deak M., Alessi D.R., van Aalten D.M. |
| Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Nichols R.J., Dzamko N., Hutti J.E., Cantley L.C., Deak M., Moran J., Bamborough P., Reith A.D., Alessi D.R. Biochem. J. 424:47-60(2009) · Mapped (3) |
| ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. Zeqiraj E., Filippi B.M., Goldie S., Navratilova I., Boudeau J., Deak M., Alessi D.R., van Aalten D.M. PLoS Biol. 7:e1000126-e1000126(2009) · Mapped (12) |
| Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Garcia-Martinez J.M., Moran J., Clarke R.G., Gray A., Cosulich S.C., Chresta C.M., Alessi D.R. Biochem. J. 421:29-42(2009) · Mapped (7) |
| Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. San-Cristobal P., Pacheco-Alvarez D., Richardson C., Ring A.M., Vazquez N., Rafiqi F.H., Chari D., Kahle K.T., Leng Q., Bobadilla N.A. et al. Proc. Natl. Acad. Sci. U.S.A. 106:4384-4389(2009) · Mapped (7) |
| Proteinuria in mice expressing PKB/SGK-resistant GSK3. Boini K.M., Amann K., Kempe D., Alessi D.R., Lang F. Am. J. Physiol. Renal Physiol. 296:F153-9(2009) · Mapped (6) |
| mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Garcia-Martinez J.M., Alessi D.R. |