| Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth. Kelly G.M., Buckley D.A., Kiely P.A., Adams D.R., O'Connor R.
J. Biol. Chem. 287:28180-28194(2012) · Mapped (4) |
| Direct interaction between scaffolding proteins RACK1 and 14-3-3zeta regulates brain-derived neurotrophic factor (BDNF) transcription. Neasta J., Kiely P.A., He D.Y., Adams D.R., O'Connor R., Ron D.
J. Biol. Chem. 287:322-336(2012) · Mapped (16) |
| Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism. Onojafe I.F., Adams D.R., Simeonov D.R., Zhang J., Chan C.C., Bernardini I.M., Sergeev Y.V., Dolinska M.B., Alur R.P., Brilliant M.H. et al.
J. Clin. Invest. 121:3914-3923(2011) · Mapped (6) |
| Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Li X., Vadrevu S., Dunlop A., Day J., Advant N., Troeger J., Klussmann E., Jaffrey E., Hay R.T., Adams D.R. et al.
Biochem. J. 428:55-65(2010) · UniProtKB (2) |
| A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex. Li X., MacLeod R., Dunlop A.J., Edwards H.V., Advant N., Gibson L.C., Devine N.M., Brown K.M., Adams D.R., Houslay M.D. et al.
FEBS Lett. 583:3310-3316(2009) · UniProtKB (3) · Mapped (2) |
| Free sialic acid storage disease without sialuria. Mochel F., Yang B., Barritault J., Thompson J.N., Engelke U.F., McNeill N.H., Benko W.S., Kaneski C.R., Adams D.R., Tsokos M. et al.
Ann. Neurol. 65:753-757(2009) · Mapped (4) |
| Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase. Kiely P.A., Baillie G.S., Barrett R., Buckley D.A., Adams D.R., Houslay M.D., O'Connor R.
J. Biol. Chem. 284:20263-20274(2009) · UniProtKB (1) · Mapped (33) |
| MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization. Meng D., Lynch M.J., Huston E., Beyermann M., Eichhorst J., Adams D.R., Klussmann E., Klusmann E., Houslay M.D., Baillie G.S.
J. Biol. Chem. 284:11425-11435(2009) · Mapped (11) |
| Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs. Xu T.-R., Baillie G.S., Bhari N., Houslay T.M., Pitt A.M., Adams D.R., Kolch W., Houslay M.D., Milligan G.
Biochem. J. 413:51-60(2008) · UniProtKB (4) · Mapped (5) |
| Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir. Garcia-Lerma J.G., Otten R.A., Qari S.H., Jackson E., Cong M.E., Masciotra S., Luo W., Kim C., Adams D.R., Monsour M. et al.
PLoS Med. 5:e28-e28(2008) · UniProtKB (3) |
| 1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1. Smith K.J., Baillie G.S., Hyde E.I., Li X., Houslay T.M., McCahill A., Dunlop A.J., Bolger G.B., Klussmann E., Adams D.R. et al.
Cell. Signal. 19:2612-2624(2007) · UniProtKB (1) · Mapped (11) |
| Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5. Bolger G.B., Baillie G.S., Li X., Lynch M.J., Herzyk P., Mohamed A., Mitchell L.H., McCahill A., Hundsrucker C., Klussmann E. et al.
Biochem. J. 398:23-36(2006) · Mapped (14) |
