Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.

A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.

UniProtKB (1) rdf/xml

Wary K.K., Mariotti A., Zurzolo C., Giancotti F.G.

Caveolin-1 functions as a membrane adaptor to link the integrin alpha subunit to the tyrosine kinase Fyn. Upon integrin ligation, Fyn is activated and binds, via its SH3 domain, to Shc. Shc is subsequently phosphorylated at tyrosine 317 and recruits Grb2. This sequence of events is necessary to couple integrins to the Ras-ERK pathway and promote cell cycle progression. These findings reveal an unexpected function of caveolin-1 and Fyn in integrin signaling and anchorage-dependent cell growth.

Cell 94:625-634(1998) [PubMed] [Europe PMC]