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Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.

Koehler M., Ansieau S., Prehn S., Leutz A., Haller H., Hartmann E.

The import of many proteins into the nucleus is mediated by the importin-alpha/beta heterodimer. While only one importin-beta gene has been found, several forms of importin-alpha have been described. In addition to the three human importin-alphas already identified, we report here the primary structure of two new human importin-alpha proteins. The five known human importin-alpha subunits can be classified into three subfamilies that appear conserved in higher eukaryotic organisms. We show by immunoblotting that the different importin-alpha subfamilies are expressed in a variety of human tissues and mammalian cell lines.

FEBS Lett. 417:104-108(1997) [PubMed] [Europe PMC]