Substitution of alanine for aspartate at position 179 in the SHV-6 extended-spectrum beta-lactamase.
Arlet G., Rouveau M., Philippon A.
SHV-6 was previously identified by its susceptibility pattern and biochemical criteria in a clinical isolate of Klebsiella pneumoniae which was resistant to ceftazidime. It contains only a single point difference with the beta laSHV-1 gene as determined by PCR amplification and nucleotide sequencing. This is the result of a single amino acid substitution, Ala for Asp, at position 179. Directed mutagenesis experiments have shown this substitution to confer selective resistance to ceftazidime in the TEM family.
FEMS Microbiol. Lett. 152:163-167(1997) [ PubMed | SRS | CiteXplore ]
