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Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome.

Chamberlain J.S., Grant S.G., Reeves A.A., Mullins L.J., Stephenson D.A., Hoffman E.P., Monaco A.P., Kunkel L.M., Caskey C.T., Chapman V.M.

The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.

Somat. Cell Mol. Genet. 13:671-678(1987) [PubMed] [Europe PMC]