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Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication.

McVey D., Brizuela L., Mohr I., Marshak D.R., Gluzman Y., Beach D.

Simian virus 40 large tumour antigen (T) is a replication origin binding protein required for viral DNA synthesis. Unphosphorylated T antigen is deficient in promoting DNA replication in vitro but can be activated by phosphorylation at residue threonine 124 by the cdc2 protein kinase. This observation demonstrates that T is regulated by phosphorylation and provides a model for cdc2 function in the control of DNA replication.

Nature 341:503-507(1989) [PubMed] [Europe PMC]