Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva.
Sugiyama K., Ogino T., Ogata K.
Three different polypeptides capable of stimulating histamine release from mast cells were isolated from human whole saliva, using heparin-gel chromatography followed by reversed-phase HPLC. The amino acid sequences of these peptides were shown to be identical to those of histatins 1, 3 and 5.