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In vitro perturbation of aggregation processes in beta-amyloid peptides: a spectroscopic study.

Sgarbossa A., Buselli D., Lenci F.

We have performed an in vitro study to investigate the molecular basis of the aggregation kinetic of 1-40 beta-amyloid peptides (Abeta and the possibility of affecting this aggregation process using an exogenous natural polycyclic pigment, hypericin (Hyp). The effect of Hyp on the self-assembly process at different times of the aggregation kinetic has been investigated utilizing a chaperon-like molecule, alpha-crystallin. Circular dichroism and fluorescence results suggest that Hyp can associate to precursors of the mature fibrils and perturb the aggregation process through intermolecular interactions with the Abeta peptides.

FEBS Lett. 582:3288-3292(2008) [PubMed] [Europe PMC]