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[Changes of matrix metalloproteinase 2,9 and tissue inhibitor of metalloproteinase 1, 2, 3 expression level in aged rat lung].

Zhao Z.J., Liu X.M., Zhou G.P.

To investigate the underlying mechanism of age related increase of pulmonary fibrosis incidenceThe levels of pulmonary collagen and TGF-beta1 protein, MMP2,9 mRNA and TIMP 1,2,3 mRNA expression were measured by ELISA and realtime PCR.As compared with adult rats [(756 +/-160) pg/g vs (1 000 +/-246) pg/g, P<0.05] the aged rats had more extracellular matrix components, increased TGF-beta1 protein level, lower (3.15 +/- 1.76 vs 0.17 +/-0.13, P<0.01) MMP2 mRNA expression and TIMP 1,2,3 mRNA expressions (TIMP1 2.00 +/- 1.74 vs 0.11 +/- 0.06,TIMP2 7.60 +/- 2.51 vs 2.69 +/-1.76, TIMP3 1.32 +/- 0.46 vs 0.29 +/-0.16, P<0.01). No difference was observed in MMP9 (1.66 +/-0.67 vs 1.74 +/-0.87, P>0.05) mRNA expression.elevation in TGF-beta1 protein level, changes in the expression of MMP2/9 and decreased expression of TIMPS mRNA could be the underlying mechanism of age related increase of pulmonary incidence.

Beijing Da Xue Xue Bao 40:101-104(2008) [PubMed] [Europe PMC]

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