Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae.
Chen Y.-T., Lauderdale T.-L., Liao T.-L., Shiau Y.-R., Shu H.-Y., Wu K.-M., Yan J.-J., Su I.-J., Tsai S.-F.
A 269-kilobase conjugative plasmid, pK29, from a Klebsiella pneumoniae strain was sequenced. The plasmid harbors multiple antimicrobial resistance genes, including those encoding CMY-8 AmpC-type and CTX-M-3 extended-spectrum beta-lactamases in the common backbone of IncHI2 plasmids. Mechanisms for dissemination of the resistance genes are highlighted in comparative genomic analyses.
Antimicrob. Agents Chemother. 51:3004-3007(2007) [ PubMed | SRS | CiteXplore ]
