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Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.

Yamakawa H., Oyama S., Mitsuhashi H., Sasagawa N., Uchino S., Kohsaka S., Ishiura S.

Recently, neuroligins (NLs)3 and 4X have received much attention as autism-related genes. Here, we identified syntrophin-gamma2 (SNTG2) as a de novo binding partner of NL3. SNTG2 also bound to NL4X and NL4Y. Interestingly, the binding was influenced by autism-related mutations, implying that the impaired interaction between NLs and SNTG2 contributes to the etiology of autism.

Biochem. Biophys. Res. Commun. 355:41-46(2007) [PubMed] [Europe PMC]