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Chromatin remodeling by nucleosome disassembly in vitro.

Lorch Y., Maier-Davis B., Kornberg R.D.

The RSC chromatin-remodeling complex completely disassembles a nucleosome in the presence of the histone chaperone Nap1 and ATP. Disassembly occurs in a stepwise manner, with the removal of H2A/H2B dimers, followed by the rest of the histones and the release of naked DNA. RSC and related chromatin-remodeling complexes may be responsible for the removal of promoter nucleosomes during transcriptional activation in vivo.

Proc. Natl. Acad. Sci. U.S.A. 103:3090-3093(2006) [PubMed] [Europe PMC]