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Kinetics of interaction of local anesthetics with human serum albumin.

Galenko-Yaroshevskii A.P., Fistunenko P.N., Dukhanin A.S.

We studied kinetic parameters of interaction of local anesthetics (lidocaine, tetracaine, bupivacaine, and two novel agents with proved local anesthetic potency RU-353 and RU-1117) with human serum albumin. Complexation of local anesthetics with human serum albumin is a time-dependent and reversible process; equilibrium was attained within 1.5-4.5 h depending on chemical nature of local anesthetics.

Bull. Exp. Biol. Med. 140:315-316(2005) [PubMed] [Europe PMC]

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