Analysis of the gene encoding copper/zinc superoxide dismutase homolog in Dictyostelium discoideum.
Akaza Y., Tsuji A., Yasukawa H.
SodD, a Cu/Zn superoxide dismutase in Dictyostelium discoideum, shows 48% identity to the cytosolic Cu/Zn superoxide dismutase (SOD) of Saccharomyces cerevisiae (SOD1). The sodD gene is expressed in D. discoideum cells at late-developmental stages. However, gene expression was not detected in the sporeless mutant, indicating that sodD is a spore cell-specific gene. The D. discoideum mutant, in which sodD was disrupted, grew and formed a multicellular structure normally, therefore the gene is not essential for growth and development. The mutant spores were sensitive to UV-light compared to the wild-type spores, indicating that SodD protects spores from cellular damage caused by UV-light.
Biol. Pharm. Bull. 25:1528-1532(2002) [ PubMed | SRS | CiteXplore ]
