Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Novel regulation and function of Src tyrosine kinase.

Ma Y.C., Huang X.Y.

Src tyrosine kinase is a critical signal transducer that modulates a wide variety of cellular functions. Misregulation of Src leads to cell transformation and cancer. Heterotrimeric guanine-nucleotide-binding proteins (G proteins) are another group of signaling molecules that transduce signals from cell-surface receptors to generate physiological responses. Recently, it was discovered that G alpha s and G alpha i could directly stimulate Src family tyrosine kinase activity. This novel regulation of Src tyrosine kinase by G proteins provides insights into the adenylyl cyclase-independent signaling mechanisms involved in ligand-induced receptor desensitization, internalization and other physiological processes.

Cell. Mol. Life Sci. 59:456-462(2002) [PubMed] [Europe PMC]