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Cell-cycle checkpoint kinases: checking in on the cell cycle.

Walworth N.C.

In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice. In addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways.

Curr. Opin. Cell Biol. 12:697-704(2000) [PubMed] [Europe PMC]