SHV-13, a novel extended-spectrum beta-lactamase, in Klebsiella pneumoniae isolates from patients in an intensive care unit in Amsterdam.
Yuan M., Hall L.M.C., Savelkoul P.H.M., Vandenbroucke-Grauls C.M.J.E., Livermore D.M.
Eleven clonally related Klebsiella pneumoniae isolates were examined. These had been isolated at an intensive care unit in Amsterdam in 1994. Their resistance was associated with a conjugative 170-kb plasmid which encoded a novel SHV beta-lactamase designated SHV-13. The SHV-13 enzyme had two substitutions compared with SHV-1: Leu35Gln and Gly238Ala. It hydrolyzed cefotaxime much more rapidly than ceftazidime or aztreonam.
Antimicrob. Agents Chemother. 44:1081-1084(2000) [ PubMed | SRS | CiteXplore ]
