| GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor. Haendeler J., Yin G., Hojo Y., Saito Y., Melaragno M., Yan C., Sharma V.K., Heller M., Aebersold R., Berk B.C.
J. Biol. Chem. 278:49936-49944(2003) GeneRIF 28964 · Mapped (28)
GIT1 is a novel regulator of PLCgamma function that mediates PLCgamma activation by c-Src and integrates signal transduction by GPCRs and TKRs GeneRIF 28964 |
| GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions. van Nieuw Amerongen G.P., Natarajan K., Yin G., Hoefen R.J., Osawa M., Haendeler J., Ridley A.J., Fujiwara K., van Hinsbergh V.W., Berk B.C.
Circ. Res. 94:1041-1049(2004) GeneRIF 28964 · Mapped (10)
GIT1 is a novel mediator in agonist-dependent signaling in ECs. GIT1 is involved in cell shape changes and may have a role as a negative feedback regulator that augments recovery of cell contraction. GeneRIF 28964 |
| A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Goehler H., Lalowski M., Stelzl U., Waelter S., Stroedicke M., Worm U., Droege A., Lindenberg K.S., Knoblich M., Haenig C. et al.
Mol. Cell 15:853-865(2004) GeneRIF 28964 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 · Mapped (69)
A protein interaction network links GIT1 an enhancer of huntingtin aggregation to Huntington disease. GeneRIF 28964 MINT-3374980. EEA1 (uniprotkb:Q15075) and GIT1 (uniprotkb:Q9Y2X7) colocalize (MI:0403) by fluorescence microscopy (MI:0416). From mint MINT MINT-243639 MINT-3375386. GIT1 (uniprotkb:Q9Y2X7) and HTT (uniprotkb:P42858) colocalize (MI:0403) by fluorescence microscopy (MI:0416). From mint MINT MINT-243639 MINT-3375526. HTT (uniprotkb:P42858) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-3375598. HTT (uniprotkb:P42858) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-3375694. HTT (uniprotkb:P42858) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 MINT-3375713. GIT1 (uniprotkb:Q9Y2X7) physically interacts (MI:0915) with HTT (uniprotkb:P42858) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 MINT-3978048. HD1.7 (uniprotkb:P42858) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-3978248. HDd1.0 (uniprotkb:P42858) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-3978858. BARD1 (uniprotkb:Q99728) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-3979553. HZFH (uniprotkb:Q12873) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-3980846. BAIP3 (uniprotkb:Q5T3J3) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-3980982. G45IP3 (uniprotkb:Q8NI70) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-3981152. HIP5 (uniprotkb:Q9PH0) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-3981338. GIT1 (uniprotkb:Q9Y2X7) physically interacts (MI:0915) with HD510Q17 (uniprotkb:P42858) by pull down (MI:0096). From mint MINT MINT-243639 MINT-3981482. BARD1 (uniprotkb:Q99728) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by pull down (MI:0096). From mint MINT MINT-243639 MINT-3981498. HIP5 (uniprotkb:Q9PH0) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by pull down (MI:0096). From mint MINT MINT-243639 MINT-3981514. HZFH (uniprotkb:Q12873) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by pull down (MI:0096). From mint MINT MINT-243639 MINT-3981546. GIT1 (uniprotkb:Q9Y2X7) physically interacts (MI:0915) with BAIP3 (uniprotkb:Q5T3J3) by pull down (MI:0096). From mint MINT MINT-243639 |
| GIT1 is a scaffold for ERK1/2 activation in focal adhesions. Yin G., Zheng Q., Yan C., Berk B.C.
J. Biol. Chem. 280:27705-27712(2005) GeneRIF 28964 · Mapped (23)
GIT1 has a role as a scaffold for ERK1/2 activation in focal adhesions GeneRIF 28964 |
| The multifunctional GIT family of proteins. Hoefen R.J., Berk B.C.
J. Cell. Sci. 119:1469-1475(2006) GeneRIF 28964 · Mapped (13)
GTI proteins regulate cytoskeletal dynamics by feedback inhibition of Rac1 they participate in receptor internalization by regulating membrane trafficking between the plasma membrane and endosomes. GeneRIF 28964 |
| Identification of phosphorylation sites in GIT1. Webb D.J., Mayhew M.W., Kovalenko M., Schroeder M.J., Jeffery E.D., Whitmore L., Shabanowitz J., Hunt D.F., Horwitz A.F.
J. Cell. Sci. 119:2847-2850(2006) GeneRIF 28964 · Mapped (7)
Mass spectrometry was to used to generate a phosphorylation map og GIT1. GeneRIF 28964 |
| Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK. Stockton R., Reutershan J., Scott D., Sanders J., Ley K., Schwartz M.A.
Mol. Biol. Cell 18:2346-2355(2007) GeneRIF 28964 · Mapped (16)
Results suggest that the PAK-PIX-GIT1 complex is critical for Erk-dependent myosin phosphorylation and vascular permeability. GeneRIF 28964 |
| GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin. Schmalzigaug R., Garron M.L., Roseman J.T., Xing Y., Davidson C.E., Arold S.T., Premont R.T.
Cell. Signal. 19:1733-1744(2007) GeneRIF 28964 · Mapped (7)
GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin. GeneRIF 28964 |
| Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1. Jones N.P., Katan M.
Mol. Cell. Biol. 27:5790-5805(2007) GeneRIF 28964 · Mapped (34)
The association of PLCgamma1 with complexes containing GIT1 and beta-Pix is essential for its role in integrin-mediated cell spreading and motility. As a component of this complex PLCgamma1 is also involved in the activation of Cdc42 and Rac1. GeneRIF 28964 |
| Regulation of adaptor protein GIT1 in platelets, leading to the interaction between GIT1 and integrin alpha(IIb)beta3. Sato H., Suzuki-Inoue K., Inoue O., Ozaki Y.
Biochem. Biophys. Res. Commun. 368:157-161(2008) GeneRIF 28964 · Mapped (18)
tyrosine phosphorylation of GIT1 by Src kinases may regulate cytoskeletal reorganization downstream of alpha(IIb)beta(3) by bringing the Rac guanine nucleotide exchange factor betaPIX to the vicinity of the integrin GeneRIF 28964 |
| GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma. Wang J., Taba Y., Pang J., Yin G., Yan C., Berk B.C.
Arterioscler. Thromb. Vasc. Biol. 29:202-208(2009) GeneRIF 28964 · Mapped (7)
GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma. GeneRIF 28964 |
| BetaPIX and GIT1 regulate HGF-induced lamellipodia formation and WAVE2 transport. Morimura S., Suzuki K., Takahashi K.
Biochem. Biophys. Res. Commun. 382:614-619(2009) GeneRIF 28964 · Mapped (18)
betaPIX and GIT1 regulate the hepatocyte growth factor-induced and Rac1-dependent membrane transport of WAVE2 and consequently lamellipodia formation. GeneRIF 28964 |
| Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling. Hajdo-Milasinovic A., van der Kammen R.A., Moneva Z., Collard J.G.
J. Cell. Sci. 122:2127-2136(2009) GeneRIF 28964 · Mapped (11)
Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling. GeneRIF 28964 |
| Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration. Hsu R.M., Tsai M.H., Hsieh Y.J., Lyu P.C., Yu J.S.
Mol. Biol. Cell 21:287-301(2010) GeneRIF 28964 · UniProtKB (1) · Mapped (23)
MYO18A is a novel binding partner of the PAK2/betaPIX/GIT1 complex and suggest that MYO18A may play an important role in regulating epithelial cell migration via affecting multiple cell machineries. GeneRIF 28964 |
| GIT1 is a novel MEK1-ERK1/2 scaffold that localizes to focal adhesions. Zhang N., Cai W., Yin G., Nagel D.J., Berk B.C.
Cell Biol. Int. 34:41-47(2010) GeneRIF 28964 · Mapped (7)
The CC domain of ERK1/2 is necessary for binding to GIT1 for ERK1/2 activation in focal adhesions and for cell spreading and migration. GeneRIF 28964 |
| An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M., Miyagawa T., Kawashima M., Tanaka S., Honda Y., Honda M., Tokunaga K.
Hum. Genet. 128:433-441(2010) GeneRIF 28964 · Mapped (688)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 28964 |
| Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6. Bhanot H., Young A.M., Overmeyer J.H., Maltese W.A.
Mol. Cancer Res. 8:1358-1374(2010) GeneRIF 28964 · Mapped (10)
Rac1 affects small GTPase Arf6 via the Arf GTPase-activating protein GIT1 as key downstream components of the signaling pathway underlying Ras-induced non-apoptotic cell death. GeneRIF 28964 |
| GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice. Won H., Mah W., Kim E., Kim J.W., Hahm E.K., Kim M.H., Cho S., Kim J., Jang H., Cho S.C. et al.
Nat. Med. 17:566-572(2011) GeneRIF 28964 · Mapped (10)
an intronic single-nucleotide polymorphism in GIT1 the minor allele of which causes reduced GIT1 expression shows a strong association with ADHD susceptibility GeneRIF 28964 |
| The adaptor protein and Arf GTPase-activating protein Cat-1/Git-1 is required for cellular transformation. Yoo S.M., Antonyak M.A., Cerione R.A.
J. Biol. Chem. 287:31462-31470(2012) GeneRIF 28964 · Mapped (7)
novel roles for Cat-1 and its interactions with the Arf GTPases and paxillin in oncogenic transformation. GeneRIF 28964 |
| GIT1 phosphorylation on serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity. Huck B., Kemkemer R., Franz-Wachtel M., Macek B., Hausser A., Olayioye M.A.
J. Biol. Chem. 287:34604-34613(2012) GeneRIF 28964 · Mapped (19)
phosphorylation of GIT1 on serine 46 by PKD3 represents a molecular switch by which GIT1 localization paxillin trafficking and cellular protrusive activity are regulated. GeneRIF 28964 |
| hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells. Metais J.-Y., Navarro C., Santoni M.-J., Audebert S., Borg J.-P.
FEBS Lett. 579:3725-3730(2005) MINT MINT-243639 · UniProtKB (2) · Mapped (5)
MINT-62251. SCRIB (uniprotkb:Q14160) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by anti tag coimmunoprecipitation (MI:0007). From mint MINT MINT-243639 |
| A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F.H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S. et al.
Cell 122:957-968(2005) MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 · UniProtKB (1) · Mapped (1,466)
MINT-63061. TXNDC9 (uniprotkb:O14530) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-63157. HBXIP (uniprotkb:O43504) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-63198. PFDN1 (uniprotkb:O60925) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-63651. HMOX2 (uniprotkb:P30519) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-63738. RGS2 (uniprotkb:P41220) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-63781. MAN2A2 (uniprotkb:P49641) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-64348. TRIB3 (uniprotkb:Q96RU7) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-64434. ITGB4BP (uniprotkb:Q5JWN5) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-64659. WDR33 (uniprotkb:Q6NUQ0) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-64697. SDCCAG3 (uniprotkb:Q6V704) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-64720. q6zqq5_human (uniprotkb:Q6ZQQ5) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-65429. DDX24 (uniprotkb:Q9GZR7) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-65509. C8orf33 (uniprotkb:Q9H7E9) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-65681. PMF1 (uniprotkb:Q6P1K2) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 MINT-65856. SRRT (uniprotkb:Q9BXP5) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by two hybrid (MI:0018). From mint MINT MINT-243639 |
| GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover. Frank S.R., Adelstein M.R., Hansen S.H.
EMBO J. 25:1848-1859(2006) MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 · Mapped (11)
MINT-1953339. GIT1 (uniprotkb:Q9Y2X7) physically interacts (MI:0915) with PXN (uniprotkb:P49023) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 MINT-1953438. GIT2 (uniprotkb:Q14161) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 MINT-1953491. GIT1 (uniprotkb:Q9Y2X7) physically interacts (MI:0915) with ARHGEF7 (uniprotkb:Q14155) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 MINT-1953519. PAK1 (uniprotkb:Q13153) physically interacts (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 |
| G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. Penela P., Ribas C., Aymerich I., Eijkelkamp N., Barreiro O., Heijnen C.J., Kavelaars A., Sanchez-Madrid F., Mayor F. Jr.
EMBO J. 27:1206-1218(2008) MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 MINT MINT-243639 · Mapped (12)
MINT-6608788. GRK2 (uniprotkb:P25098) and GIT1 (uniprotkb:Q9Y2X7) colocalize (MI:0403) by fluorescence microscopy (MI:0416). From mint MINT MINT-243639 MINT-6608861. GIT1 (uniprotkb:Q9Y2X7) physically interacts (MI:0915) with GRK2 (uniprotkb:P25098) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 MINT-6608890. physically interact (MI:0915) with GRK2 (uniprotkb:P25098) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 MINT-6608890. physically interact (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 MINT-6608906. physically interact (MI:0915) with GRK2 (uniprotkb:P25098) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 MINT-6608906. physically interact (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 MINT-6608921. physically interact (MI:0915) with GRK2 (uniprotkb:P25098) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 MINT-6608921. physically interact (MI:0915) with GIT1 (uniprotkb:Q9Y2X7) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-243639 |
