EUROSPAN Consortium
Marroni F., Pfeufer A., Aulchenko Y.S., Franklin C.S., Isaacs A., Pichler I., Wild S.H., Oostra B.A., Wright A.F., Campbell H. et al.

Circ Cardiovasc Genet 2:322-328(2009) GAD 596774 · Mapped (56)
Associated with CARDIOVASCULAR: RR interval (heart rate); GAD 596774

Brozinick J.T. Jr., Roberts B.R., Dohm G.L.

Diabetes 52:935-941(2003) GeneRIF 10000 · Mapped (12)
results show that a defect in the ability of insulin to activate Akt-2 and -3 may explain the impaired insulin-stimulated glucose transport in insulin resistance GeneRIF 10000

Tiwari G., Sakaue H., Pollack J.R., Roth R.A.

Mol. Cancer Res. 1:475-484(2003) GeneRIF 10000 · Mapped (7)
The regulation by Akt3 was found to be due to two specific regions in the Fra-1 regulatory sequence which match Sp1 consensus sites GeneRIF 10000

Xu Z., Ma D.Z., Wang L.Y., Su J.M., Zha X.L.

Biochem. Biophys. Res. Commun. 312:388-396(2003) GeneRIF 10000 · Mapped (20)
The above results indicate that PKB-Ser-473 and FAK-Tyr phosphorylation stimulated by TGF-beta1 are both dependent on cell adhesion. GeneRIF 10000

Pedrero J.M., Carracedo D.G., Pinto C.M., Zapatero A.H., Rodrigo J.P., Nieto C.S., Gonzalez M.V.

Int. J. Cancer 114:242-248(2005) GeneRIF 10000 · Mapped (8)
Dysregulation of the PI 3-K/AKT/PTEN pathway may contribute to early head neck squamous cell carcinoma tumorigenesis. GeneRIF 10000

Kanekura K., Hashimoto Y., Kita Y., Sasabe J., Aiso S., Nishimoto I., Matsuoka M.

J. Biol. Chem. 280:4532-4543(2005) GeneRIF 10000 · Mapped (26)
Rac1 PI3 kinase and Akt3 have roles in an anti-apoptotic pathway triggered by ALS2 that antagonizes SOD1 mutant-induced motoneuronal cell death GeneRIF 10000

Taniyama Y., Ito M., Sato K., Kuester C., Veit K., Tremp G., Liao R., Colucci W.S., Ivashchenko Y., Walsh K. et al.

J. Mol. Cell. Cardiol. 38:375-385(2005) GeneRIF 10000 · Mapped (2)
activation of Akt signaling results in progression from adaptive to maladaptive cardiac hypertrophy GeneRIF 10000

Cicenas J., Urban P., Vuaroqueaux V., Labuhn M., Kung W., Wight E., Mayhew M., Eppenberger U., Eppenberger-Castori S.

Breast Cancer Res. 7:R394-401(2005) GeneRIF 10000 · Mapped (7)
in breast cancer patients Akt activation is associated with tumour proliferation and poor prognosis particularly in the subset of patients with ErbB2-overexpressing tumours GeneRIF 10000

Boland E., Clayton-Smith J., Woo V.G., McKee S., Manson F.D., Medne L., Zackai E., Swanson E.A., Fitzpatrick D., Millen K.J. et al.

Am. J. Hum. Genet. 81:292-303(2007) GeneRIF 10000 · Mapped (8)
AKT3 represents an excellent candidate for developmental human MIC and ACC and we suggest that haploinsufficiency causes both postnatal MIC and ACC. GeneRIF 10000

Pham N.A., Tsao M.S., Cao P., Hedley D.W.

Pancreas 35:e16-26(2007) GeneRIF 10000 · Mapped (15)
PKB[alpha] GeneRIF 10000

Cheung M., Sharma A., Madhunapantula S.V., Robertson G.P.

Cancer Res. 68:3429-3439(2008) GeneRIF 10000 · Mapped (5)
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. GeneRIF 10000

Hirano I., Nakamura S., Yokota D., Ono T., Shigeno K., Fujisawa S., Shinjo K., Ohnishi K.

J. Biol. Chem. 284:22155-22165(2009) GeneRIF 10000 · Mapped (62)
Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1 -2 and -3 via phosphorylation on Ser-473 resulting in the proliferation of CML cells GeneRIF 10000

Shin S., Asano T., Yao Y., Zhang R., Claret F.X., Korc M., Sabapathy K., Menter D.G., Abbruzzese J.L., Reddy S.A.

Mol. Cancer Res. 7:745-754(2009) GeneRIF 10000 · Mapped (18)
Findings indicate that AP-1 has an important function in pancreatic cancer cells and provide evidence for a previously unknown Akt-mediated mechanism of c-Jun activation. GeneRIF 10000

McCauley J.L., Zuvich R.L., Bradford Y., Kenealy S.J., Schnetz-Boutaud N., Gregory S.G., Hauser S.L., Oksenberg J.R., Mortlock D.P., Pericak-Vance M.A. et al.

Genes Immun. 10:624-630(2009) GeneRIF 10000 · Mapped (71)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 10000

BRIGHT Consortium
Talmud P.J., Drenos F., Shah S., Shah T., Palmen J., Verzilli C., Gaunt T.R., Pallas J., Lovering R., Li K. et al.

Am. J. Hum. Genet. 85:628-642(2009) GeneRIF 10000 · Mapped (10,092)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 10000

Segat L., Brandao L.A., Guimaraes R.L., Pontillo A., Athanasakis E., de Oliveira R.M., Arraes L.C., de Lima Filho J.L., Crovella S.

Vaccine 28:2201-2206(2010) GeneRIF 10000 · Mapped (474)
Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) GeneRIF 10000

Kirkegaard T., Witton C.J., Edwards J., Nielsen K.V., Jensen L.B., Campbell F.M., Cooke T.G., Bartlett J.M.

Histopathology 56:203-211(2010) GeneRIF 10000 · Mapped (15)
In breast cancer AKT3 amplifications and AKT1 and AKT2 deletions were seen by FISH GeneRIF 10000

Sozopoulos E., Litsiou H., Voutsinas G., Mitsiades N., Anagnostakis N., Tseva T., Patsouris E., Tseleni-Balafouta S.

Endocr. Pathol. 21:90-100(2010) GeneRIF 10000 · Mapped (30)
We evaluated the presence of mutations in PIK3CA AKT1 AKT2 AKT3 PTEN and PDPK1 genes in 83 papillary thyroid carcinomas; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 10000

Lin J., Wang J., Greisinger A.J., Grossman H.B., Forman M.R., Dinney C.P., Hawk E.T., Wu X.

Cancer Prev Res (Phila) 3:505-517(2010) GeneRIF 10000 · Mapped (24)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 10000

Wickenden J.A., Watson C.J.

Breast Cancer Res. 12:202-202(2010) GeneRIF 10000 · Mapped (15)
Studies indicate that three different isoforms Akt1 Akt2 and Akt3 have distinct expression patterns and functions. GeneRIF 10000

Bailey S.D., Xie C., Do R., Montpetit A., Diaz R., Mohan V., Keavney B., Yusuf S., Gerstein H.C., Engert J.C. et al.

Diabetes Care 33:2250-2253(2010) GeneRIF 10000 · Mapped (10,071)
Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) GeneRIF 10000

Shao Y., Aplin A.E.

Cancer Res. 70:6670-6681(2010) GeneRIF 10000 · Mapped (5)
Mutant B-RAF melanoma cells ectopically expressing a constitutively activated form of Akt3 or endogenously expressing mutant Akt3 were protected from apoptosis induced by B-RAF knockdown or PLX4720 treatment. GeneRIF 10000

Casabonne D., Reina O., Benavente Y., Becker N., Maynadie M., Foretova L., Cocco P., Gonzalez-Neira A., Nieters A., Boffetta P. et al.

Haematologica 96:323-327(2011) GeneRIF 10000 · Mapped (719)
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 10000

Liby T.A., Spyropoulos P., Buff Lindner H., Eldridge J., Beeson C., Hsu T., Muise-Helmericks R.C.

Int. J. Cancer 130:532-543(2012) GeneRIF 10000 · Mapped (5)
These findings suggest an important role for Akt3 in the regulation of RCAS1 and VEGF secretion in ovarian cancer cells. GeneRIF 10000

Murugan A.K., Dong J., Xie J., Xing M.

Endocr. Pathol. 22:97-102(2011) GeneRIF 10000 · Mapped (8)
We did not find any mutation in the GNAQ AKT3 and PIK3R1 genes in various types of thyroid cancer. GeneRIF 10000