Sigala B., Edwards M., Puri T., Tsaneva I.R.

Exp. Cell Res. 310:357-369(2005) GeneRIF 10856 · Mapped (5)
The relocation of endogenous TIP48 to the midzone/midbody under physiological conditions suggests a novel and distinct function for TIP48 in mitosis and possible involvement in the exit of mitosis. GeneRIF 10856

Kim J.H., Choi H.J., Kim B., Kim M.H., Lee J.M., Kim I.S., Lee M.H., Choi S.J., Kim K.I., Kim S.I. et al.

Nat. Cell Biol. 8:631-639(2006) GeneRIF 10856 · Mapped (5)
sumoylation status of reptin modulates the invasive activity of cancer cells with metastatic potential GeneRIF 10856

Rousseau B., Menard L., Haurie V., Taras D., Blanc J.F., Moreau-Gaudry F., Metzler P., Hugues M., Boyault S., Lemiere S. et al.

Hepatology 46:1108-1118(2007) GeneRIF 10856 · Mapped (5)
RUVBL2 is overexpressed in a large majority of HCCs. RUVBL2 overexpression enhances tumorigenicity and RUVBL2 is required for tumor cell viability. These results argue for a major role of RUVBL2 in liver carcinogenesis. GeneRIF 10856

Venteicher A.S., Meng Z., Mason P.J., Veenstra T.D., Artandi S.E.

Cell 132:945-957(2008) GeneRIF 10856 · Mapped (8)
Study identifies the ATPases pontin and reptin as telomerase components through affinity purification of TERT from human cells. GeneRIF 10856

Gorynia S., Matias P.M., Bandeiras T.M., Donner P., Carrondo M.A.

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64:840-846(2008) GeneRIF 10856 PDB 2XSZ · Mapped (8)
Crystal structure has been solved and the solutions obtained show that the RuvBL1-RuvBL2 complex forms a dodecamer. GeneRIF 10856

Ni L., Saeki M., Xu L., Nakahara H., Saijo M., Tanaka K., Kamisaki Y.

J. Cell. Biochem. 106:920-928(2009) GeneRIF 10856 · Mapped (7)
RPAP3 interacts with Reptin to modulate UV-induced DNA damage by regulating H2AX phosphorylation GeneRIF 10856

Kakugawa S., Shimojima M., Neumann G., Goto H., Kawaoka Y.

J. Virol. 83:6429-6434(2009) GeneRIF 10856 · Mapped (5)
RBL2 inhibits influenza virus replication by suppressing influenza A virus polymerases. GeneRIF 10856

Yamada Y., Fuku N., Tanaka M., Aoyagi Y., Sawabe M., Metoki N., Yoshida H., Satoh K., Kato K., Watanabe S. et al.

Atherosclerosis 207:144-149(2009) GeneRIF 10856 · Mapped (13)
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) GeneRIF 10856

Barthelery M., Jaishankar A., Salli U., Vrana K.E.

Neurosci. Lett. 452:47-51(2009) GeneRIF 10856 · Mapped (5)
In human embryonic stem cells the Reptin52 expression increase in cell nuclei during cell differentiation. GeneRIF 10856

Cloutier P., Al-Khoury R., Lavallee-Adam M., Faubert D., Jiang H., Poitras C., Bouchard A., Forget D., Blanchette M., Coulombe B.

Methods 48:381-386(2009) GeneRIF 10856 · Mapped (24)
Is part of an RNA polymerase II-associated complex with possible chaperone activity. GeneRIF 10856

Jha S., Dutta A.

Mol. Cell 34:521-533(2009) GeneRIF 10856 · Mapped (42)
RVB1 and RVB2 function within multiple protein complexes is reviewed. GeneRIF 10856

McKeegan K.S., Debieux C.M., Watkins N.J.

Mol. Cell. Biol. 29:4971-4981(2009) GeneRIF 10856 · Mapped (15)
snoRNP assembly factor NUFIP can regulate the interactions between TIP48 and TIP49 and the core box C/D proteins. GeneRIF 10856

Oguri M., Kato K., Yokoi K., Yoshida T., Watanabe S., Metoki N., Yoshida H., Satoh K., Aoyagi Y., Nozawa Y. et al.

Am. J. Hypertens. 23:70-77(2010) GeneRIF 10856 GAD 556622 · Mapped (530)
Not Associated with CARDIOVASCULAR: hypertension; GAD 556622 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 10856

Haurie V., Menard L., Nicou A., Touriol C., Metzler P., Fernandez J., Taras D., Lestienne P., Balabaud C., Bioulac-Sage P. et al.

Hepatology 50:1871-1883(2009) GeneRIF 10856 · Mapped (8)
Reptin and Pontin protein levels are strictly controlled by a posttranslational mechanism involving proteasomal degradation of newly synthesized proteins. GeneRIF 10856

Yoshida T., Kato K., Yokoi K., Oguri M., Watanabe S., Metoki N., Yoshida H., Satoh K., Aoyagi Y., Nozawa Y. et al.

Int. J. Mol. Med. 25:649-656(2010) GeneRIF 10856 · Mapped (473)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 10856

Menard L., Taras D., Grigoletto A., Haurie V., Nicou A., Dugot-Senant N., Costet P., Rousseau B., Rosenbaum J.

J. Hepatol. 52:681-689(2010) GeneRIF 10856 · Mapped (5)
In vivo Reptin depletion leads to tumor growth arrest and may prove a valuable target in hepatocellular carcinoma. GeneRIF 10856

Izumi N., Yamashita A., Iwamatsu A., Kurata R., Nakamura H., Saari B., Hirano H., Anderson P., Ohno S.

Sci. Signal. 3:RA27-RA27(2010) GeneRIF 10856 · UniProtKB (2) · Mapped (14)
RUVBL1 and RUVBL2 control the abundance of Phosphatidylinositol 3-kinase (PI3K)-related protein kinases (PIKKs) and stimulate the formation of PIKK-containing molecular complexes such as those involved in nonsense-mediated mRNA decay. GeneRIF 10856

Niewiarowski A., Bradley A.S., Gor J., McKay A.R., Perkins S.J., Tsaneva I.R.

Biochem. J. 429:113-125(2010) GeneRIF 10856 · Mapped (8)
Several experimental approaches were used to investigate the molecular architecture of the RuvBL1-RuvBL2 complex and the role of the ATPase-insert domain (domain II) for its assembly and stability. GeneRIF 10856

Li W., Zeng J., Li Q., Zhao L., Liu T., Bjorkholm M., Jia J., Xu D.

Mol. Cancer 9:132-132(2010) GeneRIF 10856 · Mapped (12)
hTERT transcription requires constitutive expression of Reptin and its cooperation with c-MYC GeneRIF 10856

Papin C., Humbert O., Kalashnikova A., Eckert K., Morera S., Kas E., Grigoriev M.

FEBS J. 277:2705-2714(2010) GeneRIF 10856 · Mapped (6)
TIP49b hexamers were found to be inactive for ATP hydrolysis and DNA unwinding suggesting that in cells protein factors that remain unknown might be required to recycle these into an active form. GeneRIF 10856

Lee J.S., Kim Y., Kim I.S., Kim B., Choi H.J., Lee J.M., Shin H.J., Kim J.H., Kim J.Y., Seo S.B. et al.

Mol. Cell 39:71-85(2010) GeneRIF 10856 · Mapped (5)
Reptin a chromatin-remodeling factor is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. GeneRIF 10856

Maslon M.M., Hrstka R., Vojtesek B., Hupp T.R.

J. Mol. Biol. 404:418-438(2010) GeneRIF 10856 · Mapped (11)
The Reptin docking site was mapped to a divergent octapeptide loop in the AGR2 superfamily between amino acids 104 and 111. Mutations at codon Y104 or F111 in full-length AGR2 destabilized the binding of Reptin. GeneRIF 10856

Flavin P., Redmond A., McBryan J., Cocchiglia S., Tibbitts P., Fahy-Browne P., Kay E., Treumann A., Perrem K., McIlroy M. et al.

FEBS Lett. 585:2537-2544(2011) GeneRIF 10856 · Mapped (6)
data firmly implicate RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences GeneRIF 10856

Xie C., Wang W., Yang F., Wu M., Mei Y.

FEBS Lett. 586:435-441(2012) GeneRIF 10856 · Mapped (7)
Ectopic expression of RUVBL2 decreases the levels of ARF whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner. GeneRIF 10856

Machado-Pinilla R., Liger D., Leulliot N., Meier U.T.

RNA 18:1833-1845(2012) GeneRIF 10856 · Mapped (8)
First insight into the mechanism of action of pontin and reptin in the assembly of macromolecular complexes. GeneRIF 10856